Epidemiology of Surgery Associated Acute Kidney Injury (EPIS-AKI)

Epidemiology of Surgery Associated Acute Kidney Injury (EPIS-AKI)

In a comprehensive multinational study, approximately one in five patients develop PO-AKI after major surgery. Increasing severity of PO-AKI is associated with a progressive increase in adverse outcomes. Our findings indicate... read more

The impact of diabetes mellitus on morbidity and mortality in patients with COVID-19

The impact of diabetes mellitus on morbidity and mortality in patients with COVID-19

During the COVID-19 pandemic, healthcare delivery was affected in various ways. For example, acute and chronic cardiovascular diseases (CVDs) and events were less frequently observed in hospitals, both because public health... read more

Association Between Oxygen Desaturation Index and Cardiovascular Disease in Non-Sleepy SDB Subtype

Association Between Oxygen Desaturation Index and Cardiovascular Disease in Non-Sleepy SDB Subtype

In the Chinese community-dwelling population, non-sleepy sleep-disordered breathing (SDB) was highly prevalent. Oxygen desaturation index (ODI), an easily extracted indicator from a type IV sleep monitor, most strongly reflected... read more

Risks and Burdens of Incident Diabetes in Long COVID

Risks and Burdens of Incident Diabetes in Long COVID

In the post-acute phase, we report increased risks and 12-month burdens of incident diabetes and antihyperglycaemic use in people with COVID-19 compared with a contemporary control group of people who were enrolled during... read more

Clinical Profile and Recovery Pattern of Dysphagia in COVID-19 Patients

Clinical Profile and Recovery Pattern of Dysphagia in COVID-19 Patients

COVID-19 considerably impacted swallowing function in the current study. Although many patients recovered within an acceptable timeframe, some experienced persistent severe dysphagia and a protracted recovery with dependence... read more

A Cold Case of Superior Vena Cava Syndrome

A Cold Case of Superior Vena Cava Syndrome

A 61-year-old woman with hypertension, diabetes mellitus, hyperlipidemia, coronary artery disease, congestive heart failure (s/p PPM/ICD), pulmonary embolism (on warfarin), end-stage renal disease (on HD via right internal... read more

Saline vs. Balanced Crystalloid in Patients with Diabetic Ketoacidosis

Saline vs. Balanced Crystalloid in Patients with Diabetic Ketoacidosis

In patients with diabetic ketoacidosis (DKA), the use of saline may be associated with longer time to DKA resolution, higher post-resuscitation serum chloride levels, lower post-resuscitation serum bicarbonate levels, and... read more

Early Remdesivir to Prevent Progression to Severe COVID-19 in Outpatients

Early Remdesivir to Prevent Progression to Severe COVID-19 in Outpatients

Among nonhospitalized patients who were at high risk for Covid-19 progression, a 3-day course of remdesivir had an acceptable safety profile and resulted in an 87% lower risk of hospitalization or death than placebo. A... read more

Chlorthalidone Improves Blood Pressure Control in Advanced Chronic Kidney Disease with Hypertension

Chlorthalidone Improves Blood Pressure Control in Advanced Chronic Kidney Disease with Hypertension

Among patients with advanced chronic kidney disease and poorly controlled hypertension, chlorthalidone therapy improved blood-pressure control at 12 weeks as compared with placebo. A total of 160 patients underwent randomization,... read more

UK 28-Day Mortality Trends of COVID-19 Patients

UK 28-Day Mortality Trends of COVID-19 Patients

There was a marked deterioration in outcomes for patients admitted to critical care at the peak of the second wave of coronavirus disease 2019 in United Kingdom (December 2020–January 2021), compared with the post-first-wave... read more

The Obesity Paradox in Critically Ill Patients

The Obesity Paradox in Critically Ill Patients

A causal inference approach that is robust to residual confounding bias due to model misspecification and selection bias due to missing (at random) data mitigates the obesity paradox observed in critically ill patients, whereas... read more

The Truth About High-Dose Insulin

The Truth About High-Dose Insulin

The agent involved when our poison center is consulted about cases of calcium channel blocker (CCB) poisoning these days is almost invariably amlodipine. Quite often, the clinical team will be reaching for high-dose insulin... read more

Aspirin is Linked with Increased Risk of Heart Failure

Aspirin is Linked with Increased Risk of Heart Failure

Aspirin use is associated with a 26% raised risk of heart failure in people with at least one predisposing factor for the condition. That’s the finding of a study published today in ESC Heart Failure, a journal of the European... read more

Prediction Model for Severe CAP among Patients with Diabetes Mellitus

Prediction Model for Severe CAP among Patients with Diabetes Mellitus

Diabetes is an independent risk factor for the development of severe community-acquired pneumonia (CAP) and associated with pneumonia-related hospitalization as well as mortality. Here, we assessed several selected biomarkers... read more