I have avoided commenting on vitamin C for sepsis, because commentary seemed rather unnecessary. The hype was obviously ridiculous. The chances of it helping were clearly low. The evidence of benefit was negligible. Others... read more

This book, part of the European Society of Intensive Care Medicine textbook series, teaches readers how to use hemodynamic monitoring, an essential skill for today’s intensivists. It offers a valuable guide for beginners,... read more

Extended visits, development of family-mediated activities, and redirection are non-pharmacological strategies that reduce the incidence of delirium in the ICU and offer multiple benefits to the patient and family/caregiver.... read more

Plasma Biomarkers of systemic inflammation and endothelial activation are associated with ED delirium duration in older ED patients without dementia. A total of 156 patients were enrolled. IL-6 (POR = 1.59, 95%CI: 1.09–2.32)... read more

In critically ill immunocompromised patients with acute respiratory failure (ARF), the mortality rate did not differ between HFNO alone and non-invasive ventilation (NIV) alternating with high-flow nasal oxygen (HFNO). However,... read more

This book describes the techniques, strategies, and drugs that have been demonstrated by at least one paper published in a peer-reviewed journal to significantly influence survival in patients with or at risk for acute kidney... read more

A Johns Hopkins Children’s Center-led study in animals suggests that high doses of a widely used antibiotic called rifampin may safely treat and reduce the duration of treatment for the deadliest form of tuberculosis that... read more

In the post-acute phase, we report increased risks and 12-month burdens of incident diabetes and antihyperglycaemic use in people with COVID-19 compared with a contemporary control group of people who were enrolled during... read more

Sedation is an essential component of treatment for some patients admitted to the intensive care unit, but it carries a risk of sedation-related delirium. Sedation-related delirium is associated with higher mortality and... read more

Introducing the definitive resource designed for practitioners working in the rapidly expanding area of moderate procedural sedation and analgesia clinical practice. Moderate Procedural Sedation and Analgesia: A Question... read more

Acute kidney injury (AKI) occurs infrequently in young patients and often raises concern for irreversible or deadly etiologies. However, AKI related to synthetic marijuana, colloquially known as K2, is an increasingly common... read more

Acute kidney injury (AKI) is a clinical syndrome caused by a multitude of hemodynamic, toxic, and structural insults to the kidney, and portends worse patient outcomes. Despite careful history taking, physical examination,... read more

Prone position, independent of positive end-expiratory pressure levels, diminishes a maldistribution of lung stress and inflation imposed by spontaneous effort and mitigates spontaneous effort, resulting in less effort-dependent... read more

Bedside Procedures for the Intensivist delivers practical tips and clear, step-by-step instruction on the most common procedures in the ICU. The convenient and portable handbook focuses on ultrasound-guided techniques, including... read more

The functional outcomes 3 months after endovascular treatment for stroke were similar with general anesthesia and sedation. Our results, therefore, suggest that clinicians can use either approach. Of 351 randomized patients,... read more

Vasodilatory shock is the most common form of circulatory shock encountered in patients admitted to the intensive care unit (ICU). Sepsis is the predominant etiology, but other causes of vasodilatory shock include postoperative... read more

Sepsis is one of the main causes of admission to the Intensive Care Unit (ICU). It is defined as a life-threatening organ dysfunction, caused by dysregulated host response to infection (Singer et al. 2016). Septic shock is... read more