New Insights: Inhaled Nitric Oxide in Severe COVID-19 Patients

This study provides novel insights into the use of inhaled nitric oxide in severe ARDS COVID-19 patients. Specifically, we demonstrate that the iNO effect of oxygenation improvement is delayed with a prolonged feature that... read more

Tags: ARDS, COVID-19, guidelines, ICU, mechanical ventilation, oxygenation, study, treatment, vasodilation,

Handbook of Sepsis

This recently released practically oriented book provides an up-to-date overview of all significant aspects of the pathogenesis of sepsis and its management, including within the ICU. Readers will find information on the... read more

Tags: book, guidelines, ICU, immunotherapy, sepsis, therapy,

ICU-AW in Cardiogenic Shock Patients Requiring Mechanical Circulatory Support

This study provides insights into the characteristics of intensive care unit-acquired weakness (ICU-AW) in patients with Cardiogenic Shock (CS) requiring mechanical circulatory support (MCS). ICU-AW frequently occurred in... read more

Tags: biomarkers, cardiogenic shock, ECMO, hypoxia, ICU, mechanical ventilation, organ failure, study, troponin,

Hemodynamic Monitoring Using Echocardiography in the Critically Ill

The hemodynamic evaluation of patients with acute circulatory failure and respiratory failure has in the past usually been performed using invasive procedures but in recent years less invasive monitoring devices have been... read more

Tags: book, diagnosis, echocardiography, education, hemodynamics, monitoring, trauma,

Association Between Early Ondansetron Use and Sepsis Risk in ICU Patients

In both patients with SOFA 3, early ondansetron use was correlated with a reduced risk of sepsis. Patients with early ondansetron use had lower odds of experiencing sepsis than patients without early ondansetron use, which... read more

Tags: ICU, sepsis, septic shock, SIRS, SOFA, study,

Managing Recurrent Septic Shock – Dual Blood Purification with CytoSorb and oXiris

This case report presents a patient with recurrent septic shock who experienced significant clinical improvement after receiving adjunctive treatment with a combination of continuous renal replacement therapy (CRRT) using... read more

Tags: CRRT, cytokine, infection, sepsis, septic shock, SOFA, treatment,

Handbook of Critical Care Medicine

The management of critically ill patients is an important and integral part of internal medicine practice. Often, junior doctors and medical students receive insufficient training in this area of medicine. There are important... read more

Tags: book, education, ICU, training,

Rapid and Accurate Sepsis Identification Using AI

This study demonstrates that by providing streamlined predictions using CBC+DIFF data without requiring extensive clinical parameters, the AI-CDSS can be seamlessly integrated into clinical workflows, enhancing rapid, accurate... read more

Tags: AI, diagnosis, ICU, infection, pneumonia, sepsis, SOFA, technology, treatment,

Handbook of Intravenous Fluids

This easy to use pocket book covers all aspects of intravenous fluid therapy in critically ill patients from applied physiology to bedside clinical management succinctly. It includes updated and evidence-based content on... read more

Tags: book, education, resuscitation, therapy, trial,

CAR-T Therapy – Critical Care Considerations of Chimeric Antigen Receptor

Despite significantly improving the treatment of blood cancers, CAR T-cell therapy still faces significant hurdles due to its complex and varied toxicities, which require ongoing research to optimize management; while understanding... read more

Tags: arrhythmia, bleeding, coagulation, hypocalcemia, ICU, renal failure, research, therapy, thrombosis, treatment,

Approach to Peripheral Neuropathy

Peripheral neuropathy is frequently encountered in the clinical setting by doctors of various specialties. Neuropathies can be approached based on the temporal profile, spatial pattern and pathology. There is a need for eliciting... read more

Tags: diabetes, epidemiology, ICU, neuropathy, nutrition, study,

Zosyn vs. Efepime: Which One Is Safer?

While both piperacillin-tazobactam and cefepime are commonly used to treat infections caused by Pseudomonas aeruginosa in hospitalized patients, there is a concern that piperacillin-tazobactam may lead to acute kidney injury... read more

Tags: AKI, antibiotics, delirium, ICU, infection, study, trial,

Handbook of Drugs in Intensive Care: An A-Z Guide

Now in its sixth edition, the Handbook of Drugs in Intensive Care is the essential guide to using drugs safely and effectively in the intensive care setting. The book is split into two sections: an A-Z guide to the drugs... read more

Tags: book, education, guidelines, ICU, opioids, renal failure,

Cellular Therapy with Mesenchymal Stromal Cells in Sepsis

Cellular therapy with mesenchymal stromal cells (MSCs) is a promising therapeutic modality in sepsis. Positive effects are mainly associated with frequent infusions and the dose of 1 × 106 cell/kg. Larger scale studies... read more

Tags: coagulation, COVID-19, cytokine, hypoxia, infusion, sepsis, SOFA, study, therapy,

Using Critical Ultrasound To Predict Early Diagnosis of ICU-acquired Weakness in Septic Patients

This study uncovered pivotal indicators for predicting the occurrence of ICUAW in septic patients. Despite no significant difference in age, gender, BMI, BSA, or SOFA scores between the two groups, the significant differences... read more

Tags: diagnosis, ICU, inflammation, prediction, sepsis, septic shock, SOFA, study, ultrasound,

Prognostic Value of Composite Inflammatory Markers in COPD Patients

Elevated systemic immune inflammation index (SII), systemic inflammatory response index (SIRI), pan-immune inflammation value (PIV), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) are associated... read more

Tags: COPD, infection, inflammation, prognosis, pulmonology, SIRS, study,

Handbook of Evidence-Based Critical Care

This updated and revised edition of the classic bedside pocket reference remains the gold standard in critical care medicine. The new edition maintains Dr. Marik’s trademark humor and engaging writing style, while adding... read more

Tags: book, education, ICU, reference, sedation, sepsis, treatment,

Code Sepsis – Early Decompensation and Predictors

Early recognition and management of sepsis within the first hour of a sepsis alert is critical for patient survival, requiring healthcare providers to be trained to identify “red flag” symptoms like rapid breathing... read more

Tags: acidosis, ICU, qSOFA, sepsis, septic shock, SIRS, tachypnea, treatment, vasopressors,

Prolonged vs. Intermittent Infusion of Meropenem For Patients with Severe Infection

Prolonged infusion of meropenem is more effective than intermittent infusion in reducing mortality, improving clinical outcomes, and enhancing microbial eradication, without increasing adverse events. These benefits are particularly... read more

Tags: HAP, ICU, infection, infusion, pneumonia, sepsis, study, treatment, VAP,

The Point of Care Ultrasound Handbook

This NEW book is meant to be a reference for both the new and experienced point of care sonographer; to be a pocket guide to carry with you during your shift. We have included our best tips, tricks and any additional information... read more

Tags: book, guide, POCUS, reference, ultrasound,

Single Lumen vs. Double Lumen Endotracheal Tube For Postoperative Swallowing Function in Lung Transplantation Patients

BackgroundThis study was conducted to investigate the effect of endotracheal tube type on post operative dysphagia in patients undergoing lung transplant surgery. Will patients who are intubated with a single lumen endotracheal... read more

Tags: dysphagia, ICU, intubation, LOS, mechanical ventilation, study, surgery, tracheostomy, transplantation, ventilation,

Rhabdomyolysis Due to Nutritional Supplements Intake

habdomyolysis is a condition characterized by the destruction of muscle cells and subsequent release of it’s intracellular contents. It is typically asymptomatic, with moderate creatine kinase elevation. Severe cases... read more

Tags: diagnosis, ICU, nutrition, renal failure, study,

Predicting Sepsis Outcomes – Efficacy of Early Warning Scores

In resource-limited settings, NEWS proved to be the most effective tool for early risk stratification in sepsis patients. Its adoption could significantly enhance sepsis management and improve outcomes in emergency departments... read more

Tags: ICU, infection, qSOFA, sepsis, septic shock, SIRS, SOFA, treatment,

New Insights: Mortality in Nosocomial Lower Respiratory Tract Infections

This multicenter, multinational study conducted in Europe and Latin America sheds light on the clinical landscape of nLRTI, which continues to be an essential issue in the context of critical care. We provide insights into... read more

Tags: ARDS, ICU, infection, mechanical ventilation, pneumonia, study, treatment, ventilation,

The Harriet Lane Handbook: Mobile Medicine Series

Written “by residents, for residents” and reviewed by expert faculty at The Johns Hopkins Hospital, Lauren Kahl, MD and Helen K. Hughes, MD, MPH, The Harriet Lane Handbook, 21st Edition, remains your #1 source...

In Shock: My Journey from Death to Recovery and the Redemptive Power of Hope

In Shock is a riveting first-hand account from a young critical care physician, who in the passage of a moment is transfigured into a dying patient. This transposition, coincidentally timed at the end of her medical training,...