Integration Equals Separation for CRRT Filter Lifespan in ECMO Patients (E-CRRT Trial)

The multicenter randomized controlled E-CRRT Trial, conducted from May 2021 to March 2025 at King Chulalongkorn Memorial Hospital (KCMH) and Central Chest Institute of Thailand (CCIT), compared two strategies for combining... read more

Tags: AKI, CRRT, ECMO, ICU, oxygenation, RRT,

Lung Ultrasound in the Critically Ill: The BLUE Protocol

Written by a pioneer in critical care ultrasound, this book discusses the basic technique and “signatures” of lung ultrasound and explains its main clinical applications. The tools and clinical uses of the BLUE... read more

Tags: ARDS, ARF, book, education, ultrasound,

Corrected Serum Calcium Levels Predict 28-Day Death Risk in Sepsis

In a large cohort study utilizing data from 7,627 sepsis patients in the eICU Collaborative Research Database, researchers uncovered a clear U-shaped relationship between corrected serum calcium (sCa) levels and 28-day mortality.... read more

Tags: AMI, cirrhosis, CKD, COPD, COVID-19, diabetes, hypocalcemia, ICU, immunosuppression, sepsis, study,

Severe Trauma and Sepsis: Organ Damage and Tissue Repair

This book discusses recent progress in organ damage and tissue repair following severe trauma and sepsis. In part 1, it introduces the theory and clinical practice in organ damage. In part 2, it covers all the subjects of... read more

Tags: book, education, infection, inflammation, sepsis, trauma,

The Kidney Crisis: Acute Injury as a Predictor of ICU Survival

This extensive population-level study from Ontario, Canada, analyzed over 480,000 adult ICU admissions to clarify the relationship between Acute Kidney Injury (AKI) and patient outcomes. By utilizing outpatient baseline data... read more

Tags: AKI, ICU, KDIGO, mechanical ventilation, RRT, study,

Predicting Sepsis-associated Encephalopathy in Septic ICU Patients with AKI

Researchers developed a simple, interpretable nomogram to predict sepsis-associated encephalopathy (SAE) on day 1 in septic ICU patients who also have acute kidney injury (AKI), using data from the large MIMIC-IV database... read more

Tags: AKI, encephalopathy, hypernatremia, ICU, KDIGO, MAP, prognosis, SAE, sepsis, study,

Neostigmine’s Anti-Inflammatory Edge: Cholinergic Boost Slashes Cytokines, Organ Failure, and Mortality in Septic Shock

In a randomized controlled trial, researchers investigated the adjuvant use of continuous neostigmine infusion (0.2 mg/hr for 5 days) in patients with septic shock, leveraging its ability to enhance vagal cholinergic anti-inflammatory... read more

Tags: cytokine, ICU, inflammation, sepsis, septic shock, SOFA, study,

The Great Escape: How ECMO Weaning Shifts Antibiotic Levels

This case study explores the complex pharmacological landscape of treating a 47-year-old patient with severe renal impairment and pneumonia using ceftazidime–avibactam (CAZ-AVI) while on VA-ECMO support. Researchers discovered... read more

Tags: antibiotics, ECMO, HAP, ICU, pneumonia, treatment, VAP,

Life After the Pump: Quality of Life in Cardiac Surgery Survivors

Researchers have conducted a major study—the largest of its kind for this specific population—investigating the long-term quality of life (QoL) for patients who survived post-cardiotomy cardiogenic shock (PC-CS). By comparing... read more

Tags: cardiogenic shock, ECMO, ICU, SOFA, study, surgery,

Sepsis: Definitions, Pathophysiology and the Challenge of Bedside Management

A comprehensive and state-of-the-art resource for clinicians who care for patients with sepsis and research scientist alike. Patients with severe sepsis requiring ICU admission have very high rates of ICU and overall hospital... read more

Tags: book, ICU, research, sepsis, septic shock,

Metabolic Acidosis Worsens Cardiac Function and Vasopressor Needs in Septic Shock

In a prospective observational study conducted from January to December 2024 at Hospital de Especialidades No. 14, IMSS, in Veracruz, Mexico, researchers examined the cardiovascular effects of acute metabolic acidemia in... read more

Tags: acidemia, acidosis, echocardiography, ICU, sepsis, septic shock, vasopressin,

Balancing the Breath: Navigating the Brain-Lung Connection in Acute Brain Injury

This study explores the delicate tug-of-war between mechanical ventilation (MV) and outcomes for patients with Acute Brain Injury (ABI). The researchers highlight that the way we breathe for a patient can significantly influence... read more

Tags: ABI, ARDS, ICP, ICU, mechanical ventilation, PEEP, perfusion, research, vasodilation, ventilation,

Lost in Translation: Unmasking the Silent Struggle of Ineffective Ventilator Efforts

While identifying the subtle timing mismatches between a patient and a ventilator often requires specialized internal monitoring, clinicians can still spot major “asynchronies” by closely watching the flow and... read more

Tags: airway, COPD, mechanical ventilation, PEEP, ventilation,

Bedside Procedures for the Intensivist

Bedside Procedures for the Intensivist delivers practical tips and clear, step-by-step instruction on the most common procedures in the ICU. The convenient and portable handbook focuses on ultrasound-guided techniques, including... read more

Tags: book, dialysis, echocardiography, education, ICU, monitoring, tracheostomy, ultrasound,

Power to the Patient: Rethinking Pain Control in the ICU

This scoping review of 12 relevant studies suggests that Patient-Controlled Analgesia (PCA) offers a promising path toward faster and more stable pain management for ICU patients. By allowing patients to self-administer small... read more

Tags: COPD, ICU, ketamine, monitoring, opioids, study, treatment,

Beyond the Pressure: Moving Toward Personalized Sepsis Care

In the high-stakes environment of septic shock, the current clinical “gold standard” remains the early initiation of norepinephrine. However, when blood pressure targets aren’t met, the next steps often... read more

Tags: corticosteroids, hemodynamics, hydrocortisone, norepinephrine, sepsis, septic shock, vasoplegia, vasopressors,

Precision at Scale: Automating the SOFA Score for Smarter ICU Care

The Sequential Organ Failure Assessment (SOFA) score is a vital tool for diagnosing sepsis and predicting patient outcomes in the ICU, but its manual calculation is often plagued by human error and scalability issues. To... read more

Tags: diagnosis, ICU, research, sepsis, SOFA, study, technology,

Echocardiography for Intensivists

This book contains all the information that readers will require in order to perform echocardiography and to interpret the findings correctly. After an introductory chapter on the essential physics of ultrasonography, standard... read more

Tags: book, ICU, ultrasonography, ultrasound,

Breaking the Silos: How a Federated Europe Could Solve the Sepsis Puzzle

The landscape of critical care research is currently hindered by “data silos”—isolated pockets of patient information that are difficult to share due to privacy concerns and technical incompatibility. This narrative... read more

Tags: AI, ICU, research, sepsis, technology,

COVID-19 in the Air: The Hidden Viral Footprint in Hospital Waiting Rooms

New research from the Kirby Institute reveals that COVID-19 genetic material is frequently present in hospital air during community outbreaks, even in facilities with high-quality ventilation. By sampling air and surfaces... read more

Tags: COVID-19, epidemics, ICU, infection, study, ventilation, virus,

Fishman’s Pulmonary Diseases and Disorders

Since 1980, Fishman’s Pulmonary Diseases and Disorders has delivered unparalleled coverage of pulmonary medicine and the underlying basic and applied science upon which clinical practice is based. The Fifth Edition,...

Cardiovascular Complications of COVID-19: Acute and Long-Term Impacts

This book is the first comprehensive approach on COVID-19 cardiac complications, both during the acute phase as well as in the long-COVID period. It provides an up-to-date and highly illustrated summary of the biology of...