Effect of Antimicrobial De-escalation Strategy on 14-day Mortality Among ICU Patients

Effect of Antimicrobial De-escalation Strategy on 14-day Mortality Among ICU Patients

The prevalence of antimicrobial de-escalation (ADE) strategy was low among intensive care unit patients. The ADE strategy demonstrated a protective effect or no adverse effect on 14-day mortality compared to the No Change... read more

Inflammatory and Immunosuppressive Responses to COVID-19 and Bacterial Sepsis

Inflammatory and Immunosuppressive Responses to COVID-19 and Bacterial Sepsis

Bacterial sepsis patients had early, severe inflammation, profound immune suppression, and life-threatening organ dysfunction that resolved over time; SARS-CoV-2 patients had less severe early inflammation and organ dysfunction... read more

COVID-19 Variants in Patients with Immunosuppression

COVID-19 Variants in Patients with Immunosuppression

Patients with immunosuppression are at risk for prolonged infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In several case reports, investigators have indicated that multimutational SARS-CoV-2... read more

RIG-1 Agonist Shows Potent Antiviral Efficacy Against COVID-19

RIG-1 Agonist Shows Potent Antiviral Efficacy Against COVID-19

As SARS-CoV-2 continues to cause morbidity and mortality around the world, there is an urgent need for the development of effective medical countermeasures. Here, we assessed the antiviral capacity of a minimal RIG-I... read more

Clinical Distancing of Patients with Advanced Heart Failure and Cardiac Transplantation During COVID-19

Clinical Distancing of Patients with Advanced Heart Failure and Cardiac Transplantation During COVID-19

Our hospital system includes a central 825-bed, short term, acute care teaching facility where heart transplantation is performed under regulatory approval. Located 5.5 miles north of this main campus is a 107-bed cardiac... read more

Abnormalities in the Host Immune Response During Hospitalization for Sepsis

Abnormalities in the Host Immune Response During Hospitalization for Sepsis

In this cohort study of 483 patients who survived hospitalization with sepsis at 12 US hospitals, 25.8% had elevated high-sensitivity C-reactive protein levels (a marker of inflammation) at 3 months, 30.2% at 6 months, and... read more

TCR Activation Mimics CD127 low PD-1 high Phenotype and Functional Alterations of T Lymphocytes from Septic Shock Patients

TCR Activation Mimics CD127 low PD-1 high Phenotype and Functional Alterations of T Lymphocytes from Septic Shock Patients

The proportion of CD127lowPD-1high T cells in patients was increased compared with healthy volunteers, although no global CD127 regulation was observed. Our results suggest that TCR activation participates in the occurrence... read more

Implanted Organs That Won’t Be Rejected

Implanted Organs That Won’t Be Rejected

Breakthrough development uses a patient's own stomach cells, cutting the risk of an immune response to implanted organs. Israeli researchers report that they have invented the first fully personalized tissue implant, engineered... read more

Therapy Implications for Immunomodulation After Ischemic Stroke

Therapy Implications for Immunomodulation After Ischemic Stroke

Despite significant advances towards a better understanding of the pathophysiology of ischemic stroke-induced immunosuppression and SAP in recent years, many unanswered questions remain. The true incidence and outcomes of... read more