Rescue Therapy for Severe COVID-19 Associated ARDS with tPA

Rescue Therapy for Severe COVID-19 Associated ARDS with tPA

The COVID-19 pandemic has led to unprecedented stresses on modern medical systems, overwhelming the resource infrastructure in numerous countries while presenting a unique series of pathophysiologic clinical findings. Thrombotic... read more

Tube Thoracostomy during the COVID-19 Pandemic

Tube Thoracostomy during the COVID-19 Pandemic

This document provides guidance for trauma and acute care surgeons surrounding the placement, management and removal of chest tubes during the COVID-19 pandemic. Tube thoracostomy for a traumatic hemothorax or pneumothorax... read more

COVID-19: 10 Things I Wished I’d Known Some Months Ago

COVID-19: 10 Things I Wished I’d Known Some Months Ago

The COVID-19 pandemic is ongoing and spreading, affecting individuals in over 200 countries now. While COVID-19-related articles are being published every day, including guidelines of optimal clinical management, there are... read more

An Evidence-Based Approach to Pressors in Shock

An Evidence-Based Approach to Pressors in Shock

The evaluation and treatment of patients with cardiovascular shock is a cornerstone of emergency care. Unfortunately, the literature behind the use of vasoactive medications in cardiovascular shock is inconsistent. A Cochrane... read more

Translational simulation for rapid transformation of health services, using the example of the COVID-19 pandemic preparation

Translational simulation for rapid transformation of health services, using the example of the COVID-19 pandemic preparation

Healthcare simulation has significant potential for helping health services to deal with the COVID-19 pandemic. Rapid changes to care pathways and processes needed for protection of staff and patients may be facilitated by... read more

Thousands Who Got COVID-19 in March Are Still Sick

Thousands Who Got COVID-19 in March Are Still Sick

COVID-19 has existed for less than six months, and it is easy to forget how little we know about it. The standard view is that a minority of infected people, who are typically elderly or have preexisting health problems,... read more

COVID-19 Patients with ARDS Face Significant Financial Effects in Recovery

COVID-19 Patients with ARDS Face Significant Financial Effects in Recovery

Long hospitalizations lead to large medical bills, with serious physical and emotional consequences for those recovering from critical illness. It begins with shortness of breath. And for approximately one-third of patients,... read more

WHO Resumes Hydroxychloroquine Study for COVID-19

The World Health Organization is resuming a clinical trial exploring whether the malaria drug hydroxychloroquine can effectively treat COVID-19, after pausing enrollment in the study to review safety concerns about the drug. The... read more

The Perils of Premature Phenotyping in COVID-19

The Perils of Premature Phenotyping in COVID-19

The Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) poses an unprecedented global healthcare challenge. Severe novel Coronavirus disease (COVID-19) pneumonia frequently causes hypoxemic respiratory failure, manifesting... read more

Blood Vessel Attack Could Trigger Coronavirus’ Fatal Second Phase

Blood Vessel Attack Could Trigger Coronavirus’ Fatal Second Phase

Frank Ruschitzka told his pathologist to be ready before the first COVID-19 patient died. In early March, Ruschitzka, who leads the cardiology department at University Hospital Zürich, noticed that patients with the disease... read more

What’s Next for EDs in the COVID-19 Pandemic?

As of late May, most countries have falling numbers of new cases of COVID-19 and are at various stages of easing lockdown orders. This seems a good time to look back on the pandemic experience so far and at what lessons we... read more

Functional Disability 5 Years After ARDS

Functional Disability 5 Years After ARDS

Exercise limitation, physical and psychological sequelae, decreased physical quality of life, and increased costs and use of health care services are important legacies of severe lung injury. At 5 years, the median 6-minute... read more

What COVID-19 Has Taught Me

A personal narrative of Adrian Wong’s experience while battling COVID-19 at King's College Hospital. These are the author's personal opinions and do not represent the views of the institution and professional societies... read more

Near Death in the ICU

Near Death in the ICU

A phenomenal collection of medical patient accounts of encounters with the mysterious during severe illness and life-threatening injury from the voice of the physician who took care of them. Both touching and thought-provoking,... read more

Are Phenotypes a Magic Bullet for Sepsis?

Are Phenotypes a Magic Bullet for Sepsis?

There's a constant battle in medicine between practice styles—standardization and customization. Standardization is order sets and doing the same thing for every patient every time because it (hopefully) delivers better... read more

Corticosteroids for Critically Ill COVID-19 Patients with Cytokine Release Syndrome

Corticosteroids for Critically Ill COVID-19 Patients with Cytokine Release Syndrome

Approximately 5% of coronavirus disease (COVID-19) patients will require admission to an intensive care unit (ICU). Among these patients, the most severe cases may be mediated by a late-onset systemic inflammatory response... read more

Prolonged Prone Position Ventilation for SARS-CoV-2 Patients is Feasible and Effective

Prolonged Prone Position Ventilation for SARS-CoV-2 Patients is Feasible and Effective

Recently, novel coronavirus 2019 (nCOV-19) is spreading all around the world causing severe acute respiratory syndrome (SARS-CoV-2) requiring mechanical ventilation in about 5% of infected people. Prone position ventilation... read more