Predictors of Care in Persons Under Investigation for COVID-19

Predictors of Care in Persons Under Investigation for COVID-19

The healthcare burden of the coronavirus disease 2019 (COVID-19) pandemic extends beyond patients who test positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), according to a retrospective cohort study... read more

How to Intubate the Critically Ill Like a Boss

How to Intubate the Critically Ill Like a Boss

Despite decades of experience with endotracheal intubation, we continue to find approaches to improving the process of how we intubate. In today's post we are not only going to talk about how to avoid post intubation cardiac... read more

Remdesivir 5-day vs. 10-day Trial Raises Some Red Flags?

Remdesivir 5-day vs. 10-day Trial Raises Some Red Flags?

Gilead's first Randomized Controlled Trial on remdesivir was just published, and it's very interesting. This is a trial designed, monitored, and written by Gilead. In some ways, the design of the trial and its missing parts... read more

Urge Congress to Ensure that Emergency Physicians Have Due Process Rights

Urge Congress to Ensure that Emergency Physicians Have Due Process Rights

H.R. 6910, critical bipartisan legislation to ensure every emergency physician has medical staff due process rights was recently introduced by emergency physician and member of Congress, Rep. Raul Ruiz, MD (D-CA), and Rep.... read more

ICU Isolation Hood Decreases Risk of Aerosolization During Noninvasive Ventilation with COVID-19

ICU Isolation Hood Decreases Risk of Aerosolization During Noninvasive Ventilation with COVID-19

The treatment of patients with coronavirus disease (COVID-19) needs to take into consideration not only the disease process but also the availability of medical resources and the risks of transmission to healthcare providers.... read more

Spontaneous Echo Contrast in Venous Ultrasound of Severe COVID-19 Patients

Spontaneous Echo Contrast in Venous Ultrasound of Severe COVID-19 Patients

Initial reports have indicated a higher incidence of venous thromboembolism (VTE) among patients with coronavirus disease 2019 (COVID-19) compared to other critical illnesses. Helms et al. found pulmonary embolisms in 25%... read more

Long-Term Health-Related Quality of Life After Venovenous Extracorporeal Membrane Oxygenation

Long-Term Health-Related Quality of Life After Venovenous Extracorporeal Membrane Oxygenation

This study examined the long-term health-related quality of life in adult patients treated with venovenous extracorporeal membrane oxygenation (V-V ECMO) for severe acute respiratory failure in Ireland. A retrospective, cross-sectional... read more

Is Locoregional Anesthesia a Functional Option for Major Abdominal Surgeries in the COVID-19 Era?

Is Locoregional Anesthesia a Functional Option for Major Abdominal Surgeries in the COVID-19 Era?

Based on our preliminary case series, awake open surgery has resulted feasible and safe. This approach has allowed to perform undelayable major abdominal surgeries on fragile patients when intensive care beds were not available.... read more

International PICU COVID-19 Collaboration Conference Call

International PICU COVID-19 Collaboration Conference Call

This episode is an international collaborative conference call hosted by Dr. Jeffrey Burns of Boston Children's Hospital and Harvard Medical School. Featured speakers are Drs. Daniel Barouch, Trevor Duke, and Robinder Khemani,... read more

First Report on a First-in-Human Clinical Trial of a Novel Ad5 Vectored COVID-19 Vaccine

First Report on a First-in-Human Clinical Trial of a Novel Ad5 Vectored COVID-19 Vaccine

This is the first report on a first-in-human clinical trial of a novel Ad5 vectored COVID-19 vaccine. The Ad5 vectored COVID-19 vaccine was tolerated in healthy adults in all three dose groups. The most common adverse... read more

Phenotypic Heterogeneity by Site of Infection in Surgical Sepsis

Phenotypic Heterogeneity by Site of Infection in Surgical Sepsis

There are notable differences in baseline predisposition, host responses, and clinical outcomes by site of infection in surgical sepsis. While previous studies have focused on differences in hospital mortality, this study... read more

Unfractionated Heparin (UFH), LMWH, Fondaparinux, Argatroban, and Bivalirudin

Unfractionated Heparin (UFH), LMWH, Fondaparinux, Argatroban, and Bivalirudin

Unfractionated heparin (UFH) binds to anti-thrombin III (AT-III), which enhances antithrombin's inhibition of several coagulation factors – especially factor Xa and factor IIa (thrombin). Low Molecular-Weight Heparin... read more

RAAS Inhibitors and Risk of COVID-19

RAAS Inhibitors and Risk of COVID-19

The authors concluded that RAAS inhibitors do not increase the risk of COVID-19 requiring admission to the hospital, including fatal cases and those admitted to intensive care units (ICUs), and should not be discontinued... read more

Implantation of Impella CP LV Assist Device Under the Guidance of 3D Intracardiac Echocardiography

Implantation of Impella CP LV Assist Device Under the Guidance of 3D Intracardiac Echocardiography

This translational study in ovine model confirms that three-dimensional intracardiac echocardiography is a feasible option to guide implantation of the Impella CP® for left ventricular mechanical support and should be considered... read more

Prevention of Pathogen Transmission During Ultrasound Use in the ICU

Prevention of Pathogen Transmission During Ultrasound Use in the ICU

The Australasian Society for Ultrasound in Medicine (ASUM) and the Australasian College for Infection Prevention Control (ACIPC) published guidelines on minimum standards for reprocessing/cleaning of ultrasound transducers... read more

Enteral Fluid Resuscitation? The WHO to the rescue in the ED/ICU?

Enteral Fluid Resuscitation? The WHO to the rescue in the ED/ICU?

Prior to the 1970's, restricting oral intake was a "cornerstone" therapy of diarrheal illness, due to the pervasive belief that the GI tract needed time to heal and recover before resuming normal function. This was felt... read more

Simulated COVID-19 Contamination of Health Care Workers After Endotracheal Intubation of Manikins

Simulated COVID-19 Contamination of Health Care Workers After Endotracheal Intubation of Manikins

Despite personal protective equipment, fluorescent markers were found on the uncovered skin, hair, and shoes of participants after simulations of emergency department management of patients experiencing respiratory distress.... read more