Scientists create first viable mathematical model of a key anti-Salmonella defense system

Scientists create first viable mathematical model of a key anti-Salmonella defense system

Scientists have created the first validated mathematical model of an important cellular defense mechanism against the bacterium Salmonella, according to a new study in PLOS Computational Biology.... read more

Bleeding Management and Reversal Strategies for the DOAC Patient: New and Future Approaches

Todd Fraser, MD, speaks with Scott Kaatz, DO, FACP, SFHM, about his talk given at the 45th Critical Care Congress on, Bleeding Management and Reversal Strategies for the DOAC Patient: New and Future Approaches. Dr. Kaatz... read more

Palliative care intervention improves quality of life during hospitalization for hematopoietic stem cell transplantation

Palliative care intervention improves quality of life during hospitalization for hematopoietic stem cell transplantation

Palliative care involvement helps lessen quality of life (QOL) decline compared to standard care during hospitalization for hematopoietic stem cell transplantation.... read more

Hypernatremia (Uggggh!)

Hyponatremia has become a little bit sexy. Not so with sodium that is too high. But I’ve seen a bunch of less than ideal management of hypernatremia, so I figured it is time to put out a podcast about it.... read more

Physicians at RSNA make case for contrast enhanced ultrasound

Physicians at RSNA make case for contrast enhanced ultrasound

The procedure, which was OK'd by the FDA this year for liver screening, but is currently not approved in the U.S. for cardiac disease shows particular value in imaging children who may otherwise have to undergo a CT... read more

Healthcare Providers and Exercise Specialists Struggle With Prescribing Physical Activity

Healthcare Providers and Exercise Specialists Struggle With Prescribing Physical Activity

TCTMD asked cardiovascular health professionals how they approach the challenge of prescribing physical activity, their answers may surprise you.... read more

Value of Expedited Drug Approvals for Cancer Care

Value of Expedited Drug Approvals for Cancer Care

This study examines potential benefits of cancer drugs approved by the FDA on the basis of surrogate endpoints.... read more

USPSTF: Don’t Screen Asymptomatic Adults for Thyroid Cancer

USPSTF: Don’t Screen Asymptomatic Adults for Thyroid Cancer

After reviewing studies on the benefits and harms of screening and treatment for thyroid cancer, a newly released U.S. Preventive Services Task Force draft statement recommends against screening asymptomatic adults for the... read more

Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome

Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome

Higher PEEP, lower peak, plateau, and driving pressures, and lower respiratory rate are associated with improved survival from ARDS.... read more

Apnoeic oxygenation via high-flow nasal cannula oxygen combined with non-invasive ventilation preoxygenation for intubation in hypoxaemic patients in the intensive care unit

Apnoeic oxygenation via high-flow nasal cannula oxygen combined with non-invasive ventilation preoxygenation for intubation in hypoxaemic patients in the intensive care unit

A novel strategy for preoxygenation in hypoxaemic patients, adding HFNC for apnoeic oxygenation to NIV prior to orotracheal intubation, may be more effective in reducing the severity of oxygen desaturation than the reference... read more

Lower threshold for abdominal aortic aneurysm repair linked to reduced mortality

Lower threshold for abdominal aortic aneurysm repair linked to reduced mortality

The study examined the differences between the threshold of repair and aneurysm-related mortality in England and the United States. The rate of hospitalization due to a ruptured aneurysm and aneurysm-related death was significantly... read more

New anti-inflammatory drug reduces death of existing brain cells then repairs damage after stroke

New anti-inflammatory drug reduces death of existing brain cells then repairs damage after stroke

Researchers at The University of Manchester have discovered that a potential new drug reduces the number of brain cells destroyed by stroke and then helps to repair the damage.... read more

Successfully treating genetically determined autoimmune enteritis

Successfully treating genetically determined autoimmune enteritis

Using targeted immunotherapy, doctors have succeeded in curing a type of autoimmune enteritis caused by a recently discovered genetic mutation.... read more

Stroke: New drug limits brain damage and promotes repair

Stroke: New drug limits brain damage and promotes repair

Research using rats shows a drug already approved for other conditions reduces the number of brain cells killed by stroke and promotes birth of new ones.... read more

How to prevent spread of the skin infection impetigo

How to prevent spread of the skin infection impetigo

Impetigo is a contagious skin infection that's preventable and can be treated with antibiotics, the U.S. Food and Drug Administration says. Impetigo can strike anytime but is more common during warm weather months. More... read more

Limited predictability of maximal muscular pressure using the difference between peak airway pressure and positive end-expiratory pressure during proportional assist ventilation (PAV)

Limited predictability of maximal muscular pressure using the difference between peak airway pressure and positive end-expiratory pressure during proportional assist ventilation (PAV)

Deducing maximal muscular pressure from ΔP during PAV has limited accuracy. The extrapolated pressure time product from ΔP is usually less than the pressure time product calculated from oesophageal pressure tracing.... read more