Tag: antibiotics
Probiotics Offer Powerful Protection Against Sepsis in Infants
Sepsis can occur in just about anyone, including infants. Recent research shows feeding newborns probiotics (healthy bacteria) significantly lowers the child's risk of developing sepsis. The study involved infants in rural... read more
The Fallacy of Time-to-Intervention Studies
We are barraged by time-to-intervention studies (door-to-balloon time, time-to-antibiotics, door-to-needle, etc.). However, it must be kept in mind that these studies are purely correlational in design. Such studies cannot... read more
Trends and Patterns of Antibiotic Consumption in China
The consumption of antibiotics is a major driver in the development of antimicrobial resistance. This study aims to identify the trends and patterns of the total antibiotic consumption in China’s tertiary hospitals from... read more
Effect of Antibiotic Prophylaxis on Surgical Site Infections Following Removal of Orthopedic Implants
In this randomized clinical trial that included 470 patients who were undergoing surgery for removal of orthopedic implants used for treatment of below-the-knee fractures, surgical site infection occurred in 12.9% of patients... read more
A New Combination of Antibiotic and Inhibitor
Intensivists have another antibiotic combination to treat severe infections caused by gram-negative bacteria with the FDA’s approval of Vabomere (meropenem, combined with the beta-lactamase inhibitor called vaborbactam).... read more
Diagnostic Importance of Pulmonary Interleukin-1β and Interleukin-8 in VAP
BALF IL-1β and IL-8 are amongst the strongest markers yet identified for accurately demarcating VAP within the larger population of patients with suspected VAP. These findings have potential implications for reduction in... read more
Dr. Paul Wischmeyer Brings Humanity To Medicine
Dr. Paul Wischmeyer's journey to becoming an internationally-renowned critical care and perioperative nutrition researcher and clinician began at the age of 15 when a bout of strep throat and a prescription for antibiotics... read more
Increase in antibiotic-resistant bacteria hinders treatment of kidney infections
Researchers use hospital emergency room data from around the country to document emergence of E. coli strain that fights medication. They recommend development of new antibiotics and treatment guidelines.... read more
Antibiotic Prescription Course
In July, The BMJ published an analysis article called "The Antibiotic Course has had it’s day" - a provocative title that turned out the garner a lot of debate on our site. The article said that the convention for the length... read more
Workup, Management, and Critical Sequelae of Burn Injuries
Richard Iuorio, MD speaks with Laura Johnson, MD, and Jim Reilly, MD, about the workup, management, and critical sequelae of burn injuries. Using a fictional burn case as an example, Dr. Johnson talks about airway considerations,... read more
Pseudomonas aeruginosa exoproducts determine antibiotic efficacy against Staphylococcus aureus
Chronic coinfections of Staphylococcus aureus and Pseudomonas aeruginosa frequently fail to respond to antibiotic treatment, leading to significant patient morbidity and mortality. Currently, the impact of interspecies interaction... read more
Prehospital Antibiotics in the Ambulance for Sepsis
Emergency medical services (EMS) personnel have already made substantial contributions to improving care for patients with time-dependent illnesses, such as trauma and myocardial infarction. Patients with sepsis could also... read more
What’s the Effective Antibiotic Dosing in Critically Ill Patients?
Mortality due to severe infections in the intensive care unit (ICU) remains high despite recent therapeutic advancements. It is believed that ICU pathogens are relatively different from those in the general wards as they... read more
Faecal Transplant Effectively Treats Recurrent or Unresponsive Clostridium Difficile
Using a faecal microbiota transplant cured 92% of people with Clostridium difficile that had recurred or had not responded to antibiotics. Faecal transplant also had a lower risk of treatment failure than the antibiotic vancomycin.... read more
Effect of Procalcitonin-guided Antibiotic Treatment on Mortality in Acute Respiratory Infections
Use of procalcitonin to guide antibiotic treatment in patients with acute respiratory infections reduces antibiotic exposure and side-effects, and improves survival. Widespread implementation of procalcitonin protocols in... read more
Effect of Azithromycin on Asthma Exacerbations and Quality of Life in Adults with Persistent Uncontrolled Asthma
Adults with persistent symptomatic asthma experience fewer asthma exacerbations and improved quality of life when treated with oral azithromycin for 48 weeks. Azithromycin might be a useful add-on therapy in persistent asthma.... read more
The Timing of Early Antibiotics and Hospital Mortality in Sepsis
Prior sepsis studies evaluating antibiotic timing have shown mixed results. Objective: To evaluate the association between antibiotic timing and mortality among sepsis patients receiving antibiotics within 6 hours of emergency... read more
