Ketamine: A Review of an Established Yet Often Underappreciated Medication

Ketamine: A Review of an Established Yet Often Underappreciated Medication

has proven to be a complex medication with unusual properties, heterogeneous, interconnected mechanisms, and diverse, sometimes contested, clinical uses. Ketamine's story begins in 1956 when scientists identified a new... read more

The Cumulative Effect of Reporting and Citation Biases on the Apparent Efficacy of Treatments: The Case of Depression

The Cumulative Effect of Reporting and Citation Biases on the Apparent Efficacy of Treatments: The Case of Depression

The problem of study publication bias is well-known. Our examination of antidepressant trials, however, shows the pernicious cumulative effect of additional reporting and citation biases, which together eliminated most negative... read more

Effect of Reminder Devices on Medication Adherence

Effect of Reminder Devices on Medication Adherence

In this randomized clinical trial of 53 480 enrollees of a pharmacy benefit manager, no statistically significant difference in adherence was found between those in the control group and those who received a reminder device... read more