Skin Decontamination to Prevent ICU Infections

Intensive care unit (ICU)-acquired infections can be serious complications of medical care of critically ill patients. Despite multiple tested and implemented preventive measures for such infections, their incidence is persistently... read more

Octenidine Bathing Effective in Preventing ICU-acquired Primary Bacteremia

EFFECT has demonstrated that octenidine is effective at preventing primary bacteremia. The emphasis lies among Gram-positive bacteria and common skin commensals. As part of a robust bundle strategy, octenidine can serve... read more

Trends in Empiric Broad-Spectrum Antibiotic Use for Suspected Community-Onset Sepsis in US Hospitals

Empiric treatment for suspected community-onset sepsis accounts for about half of broad-spectrum antibiotic use in US hospitals even though resistant organisms are isolated in only 7% of patients with community-onset sepsis... read more

Predictive Value of Multiple Scoring Systems in the Prognosis of Septic Patients with Different Infection Sites

The heterogeneity nature of sepsis is significantly impacted by the site of infection. This study aims to explore the predictive value of multiple scoring systems in assessing the prognosis of septic patients across different... read more

Immunosuppression Not Associated with a Higher Incidence of ICU-acquired Bacterial Bloodstream Infections

Immunosuppression Not Associated with a Higher Incidence of ICU-acquired Bacterial Bloodstream Infections

In this monocentric, retrospective observational cohort study, the incidence of ICU-acquired bacterial BSI was not different between immunocompromised and non-immunocompromised patients. This suggests that the clinical... read more

Genetic Causal Factors of ARDS

Genetic Causal Factors of ARDS

This comprehensive study highlights the importance of utilizing the MR-pheWAS framework in unraveling the complex etiology and pathogenesis of ARDS, and further underlines the value of integrating blood-based biomarkers into... read more

Addressing Shortcomings in Infection and Sepsis Treatment Should Be Top of the Priority List

Addressing Shortcomings in Infection and Sepsis Treatment Should Be Top of the Priority List

Hospitals are increasingly facing the challenge of cutting costs while also improving clinical outcomes. This is certainly true in the infectious disease sector, as unrecognized or ineffectively treated bacterial infections... read more

Rapid Diagnosis of MRSA

Rapid Diagnosis of MRSA

Current standard laboratory methods for detection of oxacillin resistance require for isolation, identification, and susceptibility testing at least 48–72 h, although the multiplex PCR assay used is a rapid, sensitive,... read more

MRSA Protocols – Methods in Molecular Biology

MRSA Protocols – Methods in Molecular Biology

Presenting the most up-to-date techniques for the detection, genotyping, and investigation of methicillin-resistant S. aureus (MRSA), this second edition of Methicillin-Resistant Staphylococcus aureus (MRSA) Protocols collects... read more

Incidence, Prevalence, and Management of MRSA Bacteremia Across Patient Populations

Incidence, Prevalence, and Management of MRSA Bacteremia Across Patient Populations

Methicillin-resistant Staphylococcus aureus (MRSA) infection is still a major global healthcare problem. Of concern is S. aureus bacteremia, which exhibits high rates of morbidity and mortality and can cause metastatic or... read more

Contact Precautions for Endemic MRSA and VRE

Contact Precautions for Endemic MRSA and VRE

Physical barriers have been used to prevent infectious diseases dating back to leather gloves and coats used during the Black Death in medieval Europe. In the United States, isolation of persons with infections coincided... read more

A Placebo-Controlled Trial of Antibiotics for Smaller Skin Abscesses

A Placebo-Controlled Trial of Antibiotics for Smaller Skin Abscesses

Uncomplicated skin abscesses are common, yet the appropriate management of the condition in the era of community-associated methicillin-resistant Staphylococcus aureus (MRSA) is unclear. As compared with incision and drainage... read more

Empirical MRSA Coverage for Nonpurulent Cellulitis

Empirical MRSA Coverage for Nonpurulent Cellulitis

Cellulitis is an infection of the deep dermis and subcutaneous tissue, manifesting as expanding erythema, edema, and warmth of the skin. In most instances of cellulitis, the causative microorganism cannot be definitively... read more

Study shows brute force antibiotics can overcome resistance

Study shows brute force antibiotics can overcome resistance

Researchers at the University College London have developed a new method that may overcome antibiotic resistance in bacterial cells. The team used sensitive equipment to measure the mechanical forces that four different antibiotics,... read more

Outsourced Hospital Cleaning linked to MRSA

Outsourced Hospital Cleaning linked to MRSA

Analysis of English NHS hospitals suggests that employing private as opposed to in-house cleaners is a false economy. While it may reduce costs, it could also raise risk of infection by methicillin-resistant Staphylococcus... read more

Unnecessary Antibiotics Still Prescribed for Community-Acquired Pneumonia Due to Difficulties Identifying Resistant Strains

Unnecessary Antibiotics Still Prescribed for Community-Acquired Pneumonia Due to Difficulties Identifying Resistant Strains

Unnecessary Prescription of Antibiotics Still Prevalent Due to Difficulties in Identifying Antibiotic-Resistant Staphylococcus aureus Community-acquired Pneumonia. Researchers examined the true prevalence of methicillin (antibiotic)-resistant... read more