Tag: cholesterol
Oral PCSK9 Inhibitor Could Help Reduce LDL-C by 60%
New research from a phase 2b trial presented at American College of Cardiology meeting (ACC) 2023 suggests an oral PCSK9 inhibitor could help reduce LDL-C by 60% in patients with or at-risk for atherosclerotic cardiovascular... read more
Mechanical Ventilation Promotes Lung Tumor Spread by Modulation of Cholesterol Cell Content
Mechanical stretch of cancer cells can alter their invasiveness. During mechanical ventilation, lungs may be exposed to an increased amount of stretch, but the consequences on lung tumors have not been explored. To characterize... read more
ICU Admissions Raise Chronic Condition Risk
A new study of ICU patients in the Netherlands shows a heightened risk of developing new chronic conditions in patients after an intensive care stay. The research showed rising likelihood of conditions such as depression,... read more
Survival Benefit of a Low Ratio of Visceral to Subcutaneous Adipose Tissue Depends on LDL Clearance vs. Production in Sepsis
Patients with sepsis with a high ratio of visceral adipose tissue (VAT) to subcutaneous adipose tissue (SAT) have increased mortality. Our goal was to investigate the mechanism of this effect, noting that low LDL levels are... read more
Cholesteryl Ester Crystals in Lysosomal Acid Lipase Deficiency
Deficiency of lysosomal acid lipase is a rare autosomal recessive lysosomal storage disease characterized by the accumulation of cholesteryl esters and triglycerides, predominantly in macrophages. Nonspecific clinical features... read more
Prominent clinical guidelines fall short of conflict of interest standards
Two recent clinical practice guidelines, one for cholesterol management and another for treatment of chronic hepatitis C, did not meet the Institute of Medicine's standards for limiting commercial conflicts of interest, according... read more
Statins Associated with Reduced Alzheimer Risk
An analysis of Medicare data suggests that high use of cholesterol-lowering statins was associated with a reduced risk of Alzheimer’s disease (AD), according to an article published online in JAMA Neurology. Previous research... read more
PCSK9 Inhibition and Other New Therapies for Lipid Modification: Good News and Bad
A late-breaking clinical trial session devoted to newly approved and investigational compounds for the treatment of lipids highlighted the end of a once promising therapy for low HDL cholesterol.... read more
High-Density Lipoprotein Cholesterol and Cause-Specific Mortality in Individuals Without Previous Cardiovascular Conditions
Low and high levels of high-density lipoprotein (HDL) cholesterol are linked to increased mortality risk.... read more
Pediatric screening for family hypercholesterolemia is feasible and efficacious
Presence of a familial hypercholesterolemia mutation without elevated total cholesterol levels is insufficient to make diagnosis of familial hypercholesterolemia.... read more
Elevated HDL levels predict reduced lung function
Having an elevated level of high-density lipoprotein cholesterol (HDL-C) is associated with an increased rate of lung function decline over time, according to results from a cohort analysis of more than 30,000 adults presented... read more
