What We Should Learn From the First Wave of COVID-19

What We Should Learn From the First Wave of COVID-19

The pace at which the healthcare system has evolved in 2020 has been staggering. What system improvements we sustainably hold on to may be the most important factor in determining our community's future success. We may... read more

COVID-19: How to Quantify and Interpret Treatment Effects in Comparative Clinical Studies

COVID-19: How to Quantify and Interpret Treatment Effects in Comparative Clinical Studies

Clinical trials of treatments for coronavirus disease 2019 (COVID-19) draw intense public attention. More than ever, valid, transparent, and intuitive summaries of the treatment effects, including efficacy and harm, are needed.... read more

COVID-19: Airborne Particle Contamination Increased Substantially Using the Aerosol Box

COVID-19: Airborne Particle Contamination Increased Substantially Using the Aerosol Box

Study shows that aerosol box used to protect healthcare workers during COVID intubation increases, rather than decreases, exposure to airborne particles. A new study shows that aerosol boxes that have been manufactured... read more

Incidence of Pulmonary Embolism in Non-critically ill COVID-19 Patients

Incidence of Pulmonary Embolism in Non-critically ill COVID-19 Patients

Recent studies suggest that thrombotic complications are a common phenomenon in the novel SARS-CoV-2 infection. The main objective of our study is to assess cumulative incidence of pulmonary embolism (PE) in non critically... read more

Increase in Rare Brain Inflammation and Stroke Linked to COVID-19

Increase in Rare Brain Inflammation and Stroke Linked to COVID-19

Preliminary clinical data indicate that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with neurological and neuropsychiatric illness. Responding to this, a weekly virtual coronavirus... read more

Clinical Characteristics of Patients With COVID-19 Receiving Emergency Medical Services

Clinical Characteristics of Patients With COVID-19 Receiving Emergency Medical Services

This cohort study of 124 patients with COVID-19 revealed that most patients with COVID-19 presenting to emergency medical services were older and had multiple chronic health conditions. Initial concern, symptoms, and examination... read more

Five COVID-19 Mysteries Scientists Are Still Racing to Solve

Five COVID-19 Mysteries Scientists Are Still Racing to Solve

Six months and more than ten million confirmed cases later, the COVID-19 pandemic has become the worst public-health crisis in a century. More than 500,000 people have died worldwide. It has also catalysed a research... read more

Safe Performance of Echocardiography During the COVID-19 Pandemic

Safe Performance of Echocardiography During the COVID-19 Pandemic

Coronavirus disease-2019 (COVID-19) outbreak has become a worldwide healthcare emergency, with continuously growing number of infected subjects. Considering the easy virus spread through respiratory droplets produced with... read more

Autopsies Link Immune Response to Death from COVID-19

Autopsies Link Immune Response to Death from COVID-19

An autopsy-based study of 11 people who died from COVID-19 shows a mismatch between viral hotspots in the body and sites of inflammation and organ damage, suggesting that immune responses, rather than the virus itself, are... read more

The Ethics of Allocation

The Ethics of Allocation

One of the greatest challenges in health care - and in generations - is upon us COVID-19 continues to detrimentally affect every aspect of our healthcare system. Clinicians have been faced with grim life-and-death decisions... read more

Why, When, and How to Use Lung Ultrasound During the COVID-19 Pandemic

Why, When, and How to Use Lung Ultrasound During the COVID-19 Pandemic

The COVID-19 pandemic has further highlighted the usefulness of LUS in different clinical scenarios, underlining its advantages in terms of availability, operator- and patient-friendliness, relatively low cost and expertise... read more

Therapeutic Alternatives and Strategies for Drug Conservation in the ICU During Times of Drug Shortage

Therapeutic Alternatives and Strategies for Drug Conservation in the ICU During Times of Drug Shortage

During the coronavirus disease (COVID-19) global pandemic, urgent strategies to alleviate shortages are required. Evaluation of the feasibility, practicality, and value of drug conservation strategies and therapeutic alternatives... read more

High Risk of Thrombosis in Patients With Severe SARS-CoV-2 Infection

High Risk of Thrombosis in Patients With Severe SARS-CoV-2 Infection

Despite anticoagulation, a high number of patients with ARDS secondary to COVID-19 developed life-threatening thrombotic complications. Higher anticoagulation targets than in usual critically ill patients should therefore... read more

ICU Delirium Management During SARS-CoV-2 Pandemic

ICU Delirium Management During SARS-CoV-2 Pandemic

The novel coronavirus, SARS-CoV-2-causing Coronavirus Disease 19 (COVID-19), emerged as a public health threat in December 2019 and was declared a pandemic by the World Health Organization in March 2020. Delirium, a dangerous... read more

Cardiovascular Phenotypes in Ventilated Patients with COVID-19 ARDS

Cardiovascular Phenotypes in Ventilated Patients with COVID-19 ARDS

Approximately two-thirds of patients admitted to the intensive care unit (ICU) for coronavirus disease-19 (COVID-19) pneumonia present with the acute respiratory distress syndrome (ARDS). COVID-19-associated acute cardiac... read more

Prophylaxis and Treatment of Venous Thromboembolic Disease in COVID-19

Prophylaxis and Treatment of Venous Thromboembolic Disease in COVID-19

Patients with COVID-19 appear to be at elevated risk for thrombotic complications, including venous thromboembolism (VTE).1 In addition to traditional risk factors for VTE, indirect effects of the severity of illness as well... read more

Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients With Severe COVID-19

Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients With Severe COVID-19

Among patients with severe or life-threatening COVID-19, convalescent plasma therapy added to standard treatment, compared with standard treatment alone, did not result in a statistically significant improvement in time to... read more