Tag: COVID-19
The Ketamine Drive-Through
Patients who present with unexplained urinary tract symptoms or laboratory abnormalities on tests for liver injury should be asked about exposure to ketamine. Patients who chronically use ketamine should also be screened... read more
Half of Healthcare Workers with COVID-19 Showed Up For Work
About 50% of healthcare workers with symptomatic COVID-19 showed up for work, indicating concern over high workload burden for coworkers and personal responsibility. The findings were published in Infection Control & Hospital... read more
Heterogeneous Treatment Effects of Therapeutic-Dose Heparin in Patients Hospitalized for COVID-19
Randomized clinical trials (RCTs) of therapeutic-dose heparin in patients hospitalized with COVID-19 produced conflicting results, possibly due to heterogeneity of treatment effect (HTE) across individuals. Better understanding... read more
Combination Treatment of Persistent COVID-19 in Immunocompromised Patients
Little data exists to guide the treatment of persistent COVID-19 in immunocompromised patients. We have employed a unique protocol combining tixegavimab/cilgavimab, and short-term combination antivirals including remdesivir.... read more
Inhaled Hydrogen Efficacy on Neurological Outcome Following Brain Ischemia During Post-cardiac Arrest Care
Inhaled molecular hydrogen gas (H2) has been shown to improve outcomes in animal models of cardiac arrest (CA). H2 inhalation is safe and feasible in patients after CA. We investigated whether inhaled H2 would improve outcomes... read more
Mechanical Ventilation from Pathophysiology to Clinical Evidence
This new book aims to give a comprehensive overview of the current challenges and solution posed to the health care professionals who need to use mechanical ventilation to treat their patients. Mechanical ventilation is... read more
Postextubation Complications vs. Positive-Pressure Suctioning Techniques
Currently available studies that compared post-extubation complications in subjects managed with the positive-pressure and suctioning techniques were summarized. Further high-quality studies with a robust study design and... read more
Regular Old Pneumonia Treatment Just Got Better
In 2020, COVID-19 pneumonia became so common that "old-fashioned" bacterial pneumonia suddenly seemed rare. They look very different on x-ray. See if you can spot the differences. A new study from France tipped the scales... read more
COVID-19 in Solid Organ Transplant Recipients
Solid Organ Transplant (SOT) recipients are at high risk of severe coronavirus disease-2019. Prior to the availability of vaccination, passive immunotherapies and effective antiviral therapeutics, the outcomes of COVID-19... read more
Clinical Cases in Critical Care
In Clinical Cases in Critical Care, the authors explore core clinical topics and basic sciences in a practical and realistic way, and include comprehensive discussions focusing on critically unwell patients with a variety... read more
ICU Precision Diagnosis with Metagenomic Sequencing
Despite promising results, metagenomics remains underutilized in the ICU. Several factors still limit its inclusion in routine critical care, including the lack of definitive clinical trials testing its utility, few laboratories... read more
Practical Trends in Anesthesia and Intensive Care 2020-2021
This book offers an essential guide to managing the most-debated hot topics of practical interest in anesthesia and intensive care. Part I reviews the state of the art in issues concerning both intensive care medicine... read more
Polymorphism in Interferon Alpha/Beta Receptor Contributes to Glucocorticoid Response and Outcome of ARDS and COVID-19
The distribution of this SNP within clinical study arms may explain the contradictory results of multiple ARDS studies and outcomes in COVID-19 concerning type I IFN signaling and glucocorticoids. We found a novel disease... read more
COVID-19 Pandemic Effect on the Incidence and Survival Outcomes of EMS-witnessed OHCA
While other international studies have observed higher incidence and reduced survival in non-EMS-witnessed out-of-hospital cardiac arrest (OHCA) during the COVID-19 pandemic, this study did not identify any significant impacts... read more
Targeted Immunomodulation: A Primer for Intensivists
Targeted immunomodulation is a topic that gained wide interest from translational researchers in the past decades, yet immunomodulatory drugs were not frequently administered to intensive care patients. The coronavirus... read more
Continuous Positive Airway Pressure Usage During COVID-19
We confirm that use of early continuous positive airway pressure (CPAP) with high-flow output combined with an "ad hoc" algorithm to inform the decision to intubate is a valid and safe strategy for respiratory support in... read more
COVID-19 Treatment Guidelines New Version Published
The COVID-19 Treatment Guidelines Panel (the Panel) is pleased to announce the publication of an updated version of the Coronavirus Disease 2019 (COVID-19) Treatment Guidelines. In the United States, the prevalence of... read more
Loved Ones Are Not “Visitors” in a Patient’s Life
Hospitals are institutions whose primary task is to treat patients. Family-centered care, which considers loved ones as equal partners in patient care, has been gaining recognition in the adult care setting. Our aim was... read more
Rising Mortality in COVID-19 Patients Supported With ECMO
We aimed to describe practice patterns and outcomes in patients with extracorporeal membrane oxygenation (ECMO) support throughout the coronavirus 2019 (COVID-19) pandemic, with the hypothesis that mortality would improve... read more
Increased Risk of Hospitalization in Celiac Disease with COVID-19 Infection Is Mitigated by Vaccination
Celiac disease (CD) patients with COVID-19 have a higher risk of hospitalization compared with non-CD referents. This risk is mitigated by vaccination in CD patients as it is in non-CD referents. ICU requirement occurred... read more
Baricitinib or Tocilizumab for Severe COVID-19 Treatment
Pharmacologic treatment of COVID-19 has continued to evolve since the onset of the pandemic, and yet many questions remain about optimal treatment. Medicine strives to provide evidence-based guidance on treatments, but... read more
6 Days Higher-Dose Ivermectin vs. Placebo on Time to Sustained Recovery in COVID-19 Outpatients
Among a largely vaccinated outpatient population with mild to moderate COVID-19, treatment with ivermectin, with a targeted maximum dose of 600 μg/kg daily for 6 days, compared with placebo was not shown to improve time... read more
