Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults

Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults

Between Feb 6, 2014, and June 26, 2016, 1360 patients were assessed, and 672 were randomly assigned, with 222 in the placebo group, 227 in the 0·5 mg/kg ketamine group, and 223 in the 1·0 mg/kg ketamine group. There was... read more

Post-ICU Psychological Morbidity in Very Long ICU Stay Patients with ARDS and Delirium

Post-ICU Psychological Morbidity in Very Long ICU Stay Patients with ARDS and Delirium

Delirium was associated with memory impairment and PTSS-14 scores suggestive of PTSD, but not illness severity. 181 subjects were included. Illness severity did not correlate with delirium duration. On logistic regression,... read more

Benzodiazepines and Delirium in ICU Patients

Benzodiazepines and Delirium in ICU Patients

We have learned an extraordinary amount about ICU delirium over the last 2 decades, which is associated with increased duration of mechanical ventilation, length of hospital stay, long-term cognitive impairment, and mortality... read more

Extended ICU Visitation Model Reduces Delirium

Extended ICU Visitation Model Reduces Delirium

In this medical-surgical ICU, an extended visitation model was associated with reduced occurrence of delirium and shorter length of delirium/coma and ICU stay. Two hundred eighty-six patients were enrolled (141 restricted... read more

Worldwide Survey of the ABCDEF Bundle in the ICU

Worldwide Survey of the ABCDEF Bundle in the ICU

The current implementation of the ABCDEF bundle varies across individual components and regions. We identified specific targets for quality improvement and adoption of the ABCDEF bundle. Our data reflect a significant but... read more

Potentially modifiable factors contributing to sepsis-associated encephalopathy

Potentially modifiable factors contributing to sepsis-associated encephalopathy

Acute renal failure and common metabolic disturbances represent potentially modifiable factors contributing to sepsis-associated encephalopathy. However, a true causal relationship has yet to be demonstrated. Our study confirms... read more

Delirium in Advanced Cancer Patients Worsens Survival

Delirium in Advanced Cancer Patients Worsens Survival

Patients with advanced cancer who arrived at the ED with delirium had increased rates of hospitalization and ICU admissions, as well as shorter survival rates, according to a study published in The Oncologist. Many patients... read more

Patients with postoperative delirium more likely to suffer dementia

Patients with postoperative delirium more likely to suffer dementia

Delirium is common in elderly hospitalized patients, affecting an estimated 14 - 56% of patients. It frequently manifests as a sudden change in behavior, with patients suffering acute confusion, inattention, disorganized... read more

Preoperative Cognitive Performance and Delirium Associated With Future Dementia in Older People After Cardiac Surgery

Preoperative Cognitive Performance and Delirium Associated With Future Dementia in Older People After Cardiac Surgery

Delirium after cardiac surgery commonly, occurs in 25–67 percent of patients. Delirium is a neuropsychiatric syndrome characterized by a change in cognition fluctuates, develops over a short period of time and has an underlying... read more

Hypoactive vs Hyperactive Delirium

Hypoactive vs Hyperactive Delirium

Hypoactive delirium tends to capture less clinical attention than hyperactive delirium. Like all delirium, it can occur in a variety of patients and settings and will consequently be encountered by many groups of doctors.... read more

A Novel Computerized Test for Detecting and Monitoring Visual Attentional Deficits and Delirium in the ICU

A Novel Computerized Test for Detecting and Monitoring Visual Attentional Deficits and Delirium in the ICU

Delirium in the ICU is associated with poor outcomes but is under-detected. Here we evaluated performance of a novel, graded test for objectively detecting inattention in delirium, implemented on a custom-built computerized... read more

Differentiating Delirium From Sedative/Hypnotic-Related Iatrogenic Withdrawal Syndrome

Differentiating Delirium From Sedative/Hypnotic-Related Iatrogenic Withdrawal Syndrome

The main objectives of this study is to identify available assessment tools for sedative/hypnotic iatrogenic withdrawal syndrome and delirium in PICU patients, the evidence supporting their use, and describe areas of overlap... read more

Drug might alleviate post-surgical delirium and confusion

Drug might alleviate post-surgical delirium and confusion

To blunt postoperative pain and reduce the need for opioid drugs following surgery, anesthesiologists often give patients low doses of the drug ketamine during operations. Recent research even suggests that the drug might... read more

Intraoperative Infusion of Dexmedetomidine for Prevention of Postoperative Delirium and Cognitive Dysfunction in Elderly Patients

Intraoperative Infusion of Dexmedetomidine for Prevention of Postoperative Delirium and Cognitive Dysfunction in Elderly Patients

Intraoperative infusion of dexmedetomidine for prevention of postoperative delirium and cognitive dysfunction in elderly patients undergoing major elective non-cardiac surgery. Postoperative delirium occurs in 10% to 60%... read more