Tag: drugs
The Drug Hunters: The Improbable Quest to Discover New Medicines
The surprising, behind-the-scenes story of how our medicines are discovered, told by a veteran drug hunter. The search to find medicines is as old as disease, which is to say as old as the human race. Through serendipity—... read more
No Reason to Choose Tramadol over Morphine
Tramadol is an opioid, but it does not bind directly to opioid receptors (or it binds so weakly that it might as well not bind at all). Its opioid action is the result of the metabolite O-desmethyltramadol, which means... read more
Droperidol Use in the Emergency Department – What’s Old is New Again
Earlier this year American Reagent announced the re-introduction of droperidol back into the US market. This is bringing an old favorite back to many EM docs and a novel tool for new residents and attendings who have never... read more
Hospitals Delay Use Of New Antibiotics
According to a new study published in Diagnostic Microbiology and Infectious Disease, US hospitals on average waited more than a year to prescribe any of six new antibiotics approved by the US Food and Drug Administration... read more
Positive Topline Results for Novel Alzheimer’s Drug
A novel drug is showing promise for helping improve cognition in patients with mild to moderate Alzheimer's disease (AD), according to new topline results. A phase 3 trial of more than 800 patients showed that those who were... read more
High Generic Drug Prices and Market Competition: A Retrospective Cohort Study
Market competition levels were associated with a change in generic drug prices. Such measurements may be helpful in identifying older prescription drugs at higher risk for price change in the future. From 1.08 billion prescription... read more
Hospitals Prepare To Launch Their Own Drug Company To Fight High Prices And Shortages
Shortages of commonplace generic drugs have plagued hospitals in recent years. And with short supplies and fewer suppliers for key drugs, there have been price increases. Hospital purchasing agents keep searching for new... read more
Empiric Antibiotics Tend To Be Prolonged in ICU
Using antibiotics in critically ill patients is very much walking a tightrope. No one wants to miss an infection in a patient who could go downhill quickly, but no one wants to overuse these precious drugs, either.... read more
The 2018-2023 World Outlook for Sepsis Drugs
This study covers the world outlook for sepsis drugs across more than 190 countries. For each year reported, estimates are given for the latent demand, or potential industry earnings (P.I.E.), for the country in question... read more
Health Canada Eyes Opioid Restrictions for Popular Painkiller
Health Canada has launched a review of the increasingly popular pharmaceutical drug tramadol – a move that could prompt the department to reverse its controversial, decade-old decision not to classify the medication as... read more
Clinical Review: Paracetamol in fever in critically ill patients
Paracetamol is a synthetic, nonopioid, centrally acting analgesic and antipyretic drug. Its antipyretic effect occurres because it inhibits cyclooxygenase-3 and the prostaglandin synthesis.... read more
Therapeutic Interchange of Clevidipine For Sodium Nitroprusside in Cardiac Surgery
Sodium nitroprusside (SNP) has been used clinically for decades for the treatment of hypertension associated with cardiac surgery.... read more
Metformin and Aspirin Potential Key in Treating Inflammatory Diseases
Ingredient in aspirin combined with popular diabetes drug can turn off faulty protein that plays a key role in inflammatory diseases, such as rheumatoid arthritis. ... read more
Drug does not significantly reduce duration of mechanical ventilation for COPD patients
Among mechanically ventilated patients with COPD, administration of the respiratory stimulant acetazolamide did not significantly reduce the duration of invasive mechanical ventilation.... read more
Examining When to Provide Pain Management for Patients
Sometimes a lack of pain medication is the patient's best form of treatment. Eradicating pain has been a focus of medicine throughout history, from the early use of cocaine to the current use of fentanyl. As a prehospital... read more
Acetaminophen in the ICU: Mixed Findings
Does having a fever help fight infection? Patients who got acetaminophen to relieve fever while in intensive care units did about as well as patients who got a placebo when it came to mortality. But in a puzzling finding,... read more
Prescribed Morphine Milligram Equivalents of Opioids by County
Despite reductions in opioid prescribing in some parts of the USA, the amount of opioids prescribed remains high relative to 1999 levels and varies substantially at the county-level. Given associations between opioid prescribing,... read more
