Platelet Function During ECMO in Adult Patients

Platelet Function During ECMO in Adult Patients

Employing impedance aggregometry and flow cytometry, we found both impaired platelet aggregation and decreased platelet activation on day 1 of Extracorporeal Membrane Oxygenation (ECMO) support compared with healthy controls.... read more

Implementation of a Standardized Transfusion Protocol for Cardiac Patients Treated With Venoarterial ECMO Is Associated With Decreased Blood Component Utilization and May Improve Clinical Outcome

The data indicate that implementation of a standardized transfusion protocol, using more restrictive transfusion indications in cardiac ECMO patients, was associated with reduced blood product utilization, decreased complications,... read more

Mechanical Ventilation Management during ECMO for ARDS

Mechanical Ventilation Management during ECMO for ARDS

Ultra-protective lung ventilation on ECMO was largely adopted across medium to high case-volume ECMO centers. In contrast with previous observations, mechanical ventilation settings during ECMO did not impact patients' prognosis... read more

Mechanical Circulatory Support Devices in Cardiogenic Shock and Acute Heart Failure

Mechanical Circulatory Support Devices in Cardiogenic Shock and Acute Heart Failure

Randomized, controlled trials are utterly needed to guide treatment with mechanical circulatory support for patients with cardiogenic shock. Importantly, such trials should focus patient selection criteria. In recent years,... read more

Lung Recruitability in Severe ARDS Requiring ECMO

Lung Recruitability in Severe ARDS Requiring ECMO

Significant variability in potential for lung recruitment in patients with severe acute respiratory distress syndrome (ARDS) requiring extracorporeal membrane oxygenation (ECMO). 47 adults with severe ARDS requiring ECMO... read more

Emergency Department Resuscitation of the Critically Ill

Emergency Department Resuscitation of the Critically Ill

A crash course in Critical Care! Stabilize, treat, and save your sickest patients in the ed or the field – with ACEP's ultimate resuscitation guide. packed with succinct evidence-based chapters written by the nation's foremost... read more

Sedation Practices of Neonates Receiving ECMO

Sedation Practices of Neonates Receiving ECMO

Neonatal sedation practices during extracorporeal membrane oxygenation (ECMO) are not well described and no universal guidelines exist. Current literature describes types of medications used in adult and pediatric ECMO... read more

Risk Factors Associated with 30-day Mortality for Out-of-Center ECMO Support

Risk Factors Associated with 30-day Mortality for Out-of-Center ECMO Support

Out-of-hospital extracorporeal membrane oxygenation (ECMO) implantation and ECMO transport have become a growing field useful for emergent treatment of heart or lung failure with increasing number of centers launching such... read more

Interhospital Transport on Extracorporeal Membrane Oxygenation of Neonates

Interhospital Transport on Extracorporeal Membrane Oxygenation of Neonates

In recent years the number of extracorporeal membrane oxygenation (ECMO) cases in neonates has been relatively constant. Future expansion lays in new indications for treatment. Regionalization to high-volume ECMO centers... read more

Hemodynamic Monitoring – The Why, When, Which and What

Hemodynamic Monitoring – The Why, When, Which and What

Although the need to properly assess and monitor the hemodynamic status of a critically ill patient appears self-evident, the plethora of information in the published literature over the past two decades has resulted in complexity... read more

ECMO and Bloodstream Infection in Congenital Diaphragmatic Hernia

ECMO and Bloodstream Infection in Congenital Diaphragmatic Hernia

The objective of this review is to characterize the risk of bloodstream infection (BSI) and urinary tract infection (UTI) and describe antibiotic use in infants with congenital diaphragmatic hernia (CDH) requiring extracorporeal... read more

How Best to Set the Ventilator on Extracorporeal Membrane Lung Oxygenation

How Best to Set the Ventilator on Extracorporeal Membrane Lung Oxygenation

Mechanical ventilation and extracorporeal support are marginally integrated. The best environment for lung healing – complete lung collapse or protective ventilation strategy or fully open and immobile lung (all three conditions... read more

Time-Course of Clinical Physiologic Variables in ARDS Patients Undergoing ECMO

Time-Course of Clinical Physiologic Variables in ARDS Patients Undergoing ECMO

In patients undergoing extracorporeal membrane oxygenation (ECMO) for acute respiratory distress syndrome (ARDS), it is unknown which clinical physiologic variables should be monitored to follow the evolution of lung injury... read more

Hemodynamic Monitoring in the ECMO Patient

Hemodynamic Monitoring in the ECMO Patient

Hemodynamic monitoring in extracorporeal membrane oxygenation (ECMO) patients requires familiarity with the underlying pathophysiology and circulatory mechanics of extracorporeal flow. This review discusses the various monitoring... read more

Prevalence and outcome of heparin-induced thrombocytopenia diagnosed under veno-arterial extracorporeal membrane oxygenation

Prevalence and outcome of heparin-induced thrombocytopenia diagnosed under veno-arterial extracorporeal membrane oxygenation

Prevalence of HIT among patients under VA‑ECMO is extremely low at 0.36% with an associated mortality rate of 33.3%, which appears to be in the same range as that observed in patients treated with VA‑ECMO without HIT.... read more

Identifying At-Risk Patients for Sub-optimal Beta-lactam Exposure in Critically Ill Patients with Severe Infections

Identifying At-Risk Patients for Sub-optimal Beta-lactam Exposure in Critically Ill Patients with Severe Infections

Conventional beta-lactam dosing is flawed in critically ill patients. Useful tools such as the MeroRisk Calculator need to be comprehensively evaluated clinically, and if successful should be added into clinical practice... read more

Neuromuscular Blockade for ARDS Was No Help, In Supine Patients

Neuromuscular Blockade for ARDS Was No Help, In Supine Patients

Continuous neuromuscular blockade for severe ARDS became common practice after the ACURASYS trial showed it reduced mortality by an absolute 9%. A larger trial, ROSE, now finds no benefit of the therapy over usual care, but... read more