Analysis of Fentanyl Pharmacokinetics and Tolerance in Critically-Ill Children

Analysis of Fentanyl Pharmacokinetics and Tolerance in Critically-Ill Children

Different weight-based fentanyl dosing rates may be required for infants and children of different ages to achieve similar plasma concentrations. Using SBS scores may guide the dosing titration of fentanyl that resulted in... read more

Rapid Resilience in the Emergency Department

Rapid Resilience in the Emergency Department

It is the middle of a busy shift when you get the call that multiple casualties are incoming from a large fire. Your team scrambles to respond as the first victim, a 23 year old with 30% TBSA burns rolls in. He’s screaming... read more

Fentanyl Infusion Pharmacokinetics Variables in Obese and Nonobese Children

Fentanyl Infusion Pharmacokinetics Variables in Obese and Nonobese Children

The differences in total clearance (CLS) may increase less than proportional to weight in obese children greater than 6-year-olds, while volume of distribution at steady state increases more than proportional to weight in... read more

Intravenous Lidocaine Does Not Improve Neurologic Outcomes after Cardiac Surgery

Intravenous Lidocaine Does Not Improve Neurologic Outcomes after Cardiac Surgery

Intravenous lidocaine administered during and after cardiac surgery did not reduce postoperative cognitive decline at 6 weeks. Among the 420 allocated subjects who returned for 6-week follow-up, there was no difference in... read more

Prehospital Intravenous Fentanyl Administered by Ambulance Personnel

Prehospital Intravenous Fentanyl Administered by Ambulance Personnel

Prehospital acute pain is a frequent symptom that is often inadequately managed. The concerns of opioid induced side effects are well-founded. To ensure patient safety, ambulance personnel are therefore provided with treatment... read more