Prophylactic hydration to protect renal function from intravascular iodinated contrast material in patients at high risk of contrast-induced nephropathy

Between June 17, 2014, and July 17, 2016, 660 consecutive patients were randomly assigned to receive no prophylaxis (n=332) or intravenous hydration (n=328). 2–6 day serum creatinine was available for 307 (92%) of 332 patients... read more

Prophylactic hydration to protect renal function from intravascular iodinated contrast material in patients at high risk of contrast-induced nephropathy

Pain Assessment in INTensive care (PAINT)

Pain is a common and distressing symptom experienced by intensive care patients. Assessing pain in this environment is challenging, and published guidelines have been inconsistently implemented. The Pain Assessment in INTensive... read more

Pain Assessment in INTensive care (PAINT)

Major publications in the critical care pharmacotherapy literature

The Critical Care Pharmacotherapy Literature Update (CCPLU) Group is composed of over 50 experienced critical care pharmacists who evaluate 31 peer-reviewed journals monthly to identify literature pertaining to pharmacotherapy... read more

Major publications in the critical care pharmacotherapy literature

AAP: Recommendations for Preventive Pediatric Health Care

The 2017 Recommendations for Preventive Pediatric Health Care (Periodicity Schedule) have been approved by the American Academy of Pediatrics (AAP) and represents a consensus of AAP and the Bright Futures Periodicity Schedule... read more

AAP: Recommendations for Preventive Pediatric Health Care

Guidelines for Family-Centered Care in the Neonatal, Pediatric, and Adult ICU

The primary goal of these guidelines is to identify best practices for family-centered care in the ICU based on existing evidence. These guidelines were developed using a rigorous, objective, and transparent assessment of... read more

Guidelines for Family-Centered Care in the Neonatal, Pediatric, and Adult ICU

Wide variations found in evaluation of newborns for sepsis

The evaluation of well-appearing term infants for early-onset sepsis (EOS) varies considerably among hospitals, with some doing extensive work-ups and giving antibiotics while others simply observe and provide newborn routine... read more

Wide variations found in evaluation of newborns for sepsis

Manufacturer guidelines fall short for endoscope reprocessing

A just-published study finds that current endoscopic manufacturer cleaning instructions for a wide range of GI, urological and respiratory devices used in diagnostic procedures still fail to protect patients from the risk... read more

Manufacturer guidelines fall short for endoscope reprocessing

Hydrocortisone Fails to Prevent Septic Shock

Hydrocortisone failed to reduce the risk of septic shock in severe sepsis patients in recent research, though its authors held out hope that a larger study could show a better result. Current guidelines recommend hydrocortisone... read more

Hydrocortisone Fails to Prevent Septic Shock

Six myths promoted by the new surviving sepsis guidelines

The Rivers trial and the Surviving Sepsis Campaign popularized sepsis protocols, which saved lives. Massive accomplishment. However, that doesn’t validate the individual components of early goal-directed therapy. Any protocol... read more

Six myths promoted by the new surviving sepsis guidelines

Protocol Lacking for Post-op Delirium

While 70% of anesthesiologists say they "frequently" or "occasionally" encounter postoperative delirium in their practices, more than three-fourths (77%) lack a process to screen for at-risk patients.... read more

Protocol Lacking for Post-op Delirium

Nutrition in critically ill adults: A systematic quality assessment of clinical practice guidelines

Nutritional support in the acutely ill is a complex topic. Clinical practice guidelines (CPGs) have been developed to assist healthcare professionals working in this field. However, the quality of these clinical guidelines... read more

Nutrition in critically ill adults: A systematic quality assessment of clinical practice guidelines

New Infection Data and Sepsis-Guideline Critique at SCCM

The potential of probiotics to reduce nosocomial infections and ventilator-associated pneumonia in the critically ill and the latest data on readmissions will be among the major research advances presented here at the Society... read more

New Infection Data and Sepsis-Guideline Critique at SCCM

Prominent clinical guidelines fall short of conflict of interest standards

Two recent clinical practice guidelines, one for cholesterol management and another for treatment of chronic hepatitis C, did not meet the Institute of Medicine's standards for limiting commercial conflicts of interest, according... read more

Prominent clinical guidelines fall short of conflict of interest standards

Liberation from Mechanical Ventilation in Critically Ill Adults

Official Executive Summary of an American Thoracic Society/American College of Chest Physicians Clinical Practice Guideline: Liberation from Mechanical Ventilation in Critically Ill Adults. The panel provides recommendations... read more

Liberation from Mechanical Ventilation in Critically Ill Adults

ACC Releases Afib Treatment Interruption Guidelines

Revised recommendations released today by the American College of Cardiology are designed to help clinicians determine if, and for how long, Afib patients on anticoagulants should be taken off the medications before scheduled... read more

ACC Releases Afib Treatment Interruption Guidelines

Alpha blockers more effective for large kidney stones

Researchers report a 57 percent higher risk of stone passage for larger stones with an alpha blocker, but no benefit for smaller stones. Location did not make a difference, nor did type of alpha blocker used.... read more

Alpha blockers more effective for large kidney stones

Adherence to guidelines reduces catheter-associated UTIs

Adherence to CDC guidelines for the placement, maintenance and removal of catheters and American College of Critical Care Medicine and Infectious Disease Society of America guidelines for evaluating fever in a critically... read more

Adherence to guidelines reduces catheter-associated UTIs

New statin guidelines issued for primary CVD prevention

The United States Preventive Services Task Force have issued new recommendations for the use of statins in primary prevention of cardiovascular disease.... read more

New statin guidelines issued for primary CVD prevention

Impact of a high loading dose of amikacin in patients with severe sepsis or septic shock

With a loading dose of 30 mg/kg of amikacin, concentration was potentially suboptimal. The pharmacodynamic target (60 mg/L < C max < 80 mg/L) recommended by French guidelines was reached in 41.8% of patients and was... read more

Impact of a high loading dose of amikacin in patients with severe sepsis or septic shock

Guidelines for Neuromuscular Blockade in the Adult Critically Ill Patient

The Society of Critical Care Medicine recently released guidelines addressing sustained neuromuscular blockade in the adult critically ill patient.... read more

Guidelines for Neuromuscular Blockade in the Adult Critically Ill Patient