Defending the Vulnerable: Neutropenic Sepsis Outcomes Improve Despite Higher Risk

A decade-long, single-center study in a French ICU examined the characteristics and outcomes of 185 consecutive patients admitted with neutropenic sepsis or septic shock between 2012 and 2022. The analysis revealed a... read more

More Than Just Acid: Navigating the Complexities of Lactate in Critical Care

Lactate is a vital marker in critical care, but its meaning is complex, reflecting an interplay of perfusion, metabolism, organ function, and stress. Clinicians must adopt a nuanced, multimodal approach to interpretation,... read more

Lactate Fails to Boost Predictive Power in Post-Op Cardiac Patients

This retrospective study analyzed over 2,500 adult patients to determine if lactate dynamics—including clearance time, trend, and maximum level—offer incremental value in predicting poor outcomes after cardiac surgery,... read more

Lactate Trajectory Models for Predicting AKI and Mortality in Hyperlactatemia Patients

The present study underscores the significant prognostic value of lactate trajectories in critically ill patients, particularly those with hyperlactatemia. Our findings suggest that rapid lactate clearance is strongly... read more

Citrate Anticoagulation for CRRT

Regional citrate anticoagulation (RCA) is a viable option for liver failure patients. The pro-posed inducible metabolic pathway hypothesis challenges the belief in hepatic dominance over citrate metabolism during RCA-CRRT.... read more