Tag: immunotherapy
Handbook of Sepsis
This recently released practically oriented book provides an up-to-date overview of all significant aspects of the pathogenesis of sepsis and its management, including within the ICU. Readers will find information on... read more
Targeted Immunomodulation: A Primer for Intensivists
Targeted immunomodulation is a topic that gained wide interest from translational researchers in the past decades, yet immunomodulatory drugs were not frequently administered to intensive care patients. The coronavirus... read more
Immunotherapy
The field of immuno-oncology continues to rapidly evolve as new insights to fight and treat cancer emerge. The fourth edition of Immunotherapy provides the most current overview of immuno-oncology in different cancer types... read more
Enhancing anti-tumour efficacy with immunotherapy combinations
Several tumour types are responsive to immunotherapy, as shown by regulatory approvals for immune checkpoint inhibitors. However, many patients either do not respond or do not have durable clinical benefit. Thus, there... read more
Serum Ferritin Identifies Septic Patients with Macrophage Activation-like Syndrome
A serum ferritin level above 4420 ng/ml identifies in a reliable and very specific way the septic patient with macrophage activation-like syndrome (MALS). Since the recent subgroup analysis indicated a survival benefit... read more
Immunotherapy Effects on Sepsis
A randomised controlled multicentre trial assessed for the first time the safety and pharmacokinetics of an antiprogrammed cell death-ligand 1 (anti–PD-L1) immune checkpoint inhibitor (BMS-936559; Bristol-Myers Squibb,... read more
Management of the Critically Ill Adult Chimeric Antigen Receptor-T Cell Therapy Patient
Until modifications in chimeric antigen receptor T-cell therapy decrease their toxicities, the intensivist will play a leading role in the management of critically ill chimeric antigen receptor T-cell patients. As this novel... read more
Non-antibiotic treatments for bacterial diseases in an antibiotic resistance era
The progressive spread of antibiotic resistance genes is forcing us to reconsider our treatment options against some bacterial pathogens. Treating bacterial infections will likely become more challenging in the future. We... read more
Successfully treating genetically determined autoimmune enteritis
Using targeted immunotherapy, doctors have succeeded in curing a type of autoimmune enteritis caused by a recently discovered genetic mutation.... read more
Fatal Myocarditis – Rare New ADR With Immunotherapy
Two case reports of fatal myocarditis occurring in patients with melanoma being treated with immunotherapy, which appear to be a T-cell-driven drug reaction.... read more
Dramatic remissions seen in immunotherapy trial of blood cancer patients
Many patients with advanced blood cancers who are receiving experimental, "living" immunotherapy as part of a clinical trial are experiencing sustained remissions, according to preliminary results of the ongoing... read more
