Tag: toxicity
Propofol in ICU Settings: Understanding and Managing Anti-Arrhythmic, Pro-Arrhythmic Effects, and Propofol Infusion Syndrome
Propofol has revolutionized anesthesia and intensive care medicine owing to its favorable pharmacokinetic characteristics, fast onset, and short duration of action. This drug has been shown to be remarkably effective in numerous... read more
Clarifying the Fictions Surrounding Sepsis: Strategies for Improved Management and Outcomes
It is important to clarify the myths surrounding sepsis and to provide a clear understanding of the condition. This can help set realistic expectations about outcomes and inform effective strategies for managing sepsis, including... read more
High Dose Insulin and Euglycemia Therapy for Beta-adrenergic Receptor Treatment and Calcium Channel Antagonists Overdose
High dose insulin with dextrose supplementation is indicated for patients with calcium channel blocker and beta blocker overdose and signs of cardiac toxicity. Mechanisms are not completely elucidated, but mostly related... read more
Immunotherapy
The field of immuno-oncology continues to rapidly evolve as new insights to fight and treat cancer emerge. The fourth edition of Immunotherapy provides the most current overview of immuno-oncology in different cancer types... read more
Organophosphorus Compounds and Oximes
Organophosphorus (OP) pesticides and nerve agents still pose a threat to the population. Treatment of OP poisoning is an ongoing challenge and burden for medical services. Standard drug treatment consists of atropine and... read more
Approach to the Critically Ill Poisoned Patient
Toxicology histories are notoriously unreliable. Any available medical records, especially medication lists. Timing & amount of ingestions. Immediate vs. sustained-release formulations. Consider inquiring specifically... read more
Human ACE2 peptide-mimics block SARS-CoV-2 pulmonary cells infection
The current pandemic originated by SARS-CoV-2 causes an unprecedented health crisis. The medical world has found itself helpless in the face of this virus, having to deal with the absence of specific effective treatment.... read more
Antimicrobial‑associated Harm in Critical Care
The belief that, for the individual patient, the benefit of prompt and continued use of antimicrobials outweighs any potential harm is a significant barrier to improved stewardship of these vital agents. Antimicrobial... read more
Intentional Hydroxychloroquine Overdose Treated with High-Dose Diazepam
This case demonstrates the importance of rapid recognition and treatment of hydroxychloroquine poisoning. We anticipate that clinicians may be asked to recognize and manage this toxidrome in increasing frequency as attention... read more
How Should We Treat Acinetobacter Pneumonia?
The optimal treatment for multidrug-resistant A. baumannii pneumonia has not been established. New therapeutic options are urgently needed. Well designed, randomized controlled trials must been conducted to comprehensively... read more
The Poor Man’s Tox Screen: ECG Findings in the Acute Overdose
In the middle of a busy ED shift the tech runs up to you with an ECG. Just prior to signing the top "No STEMI" you think: "wait, why do the QRS complexes look like that?" You walk back to triage with the tech to see a... read more
Acute Salicylate Toxicity, Mechanical Ventilation, and Hemodialysis
In patients requiring intubation from acute salicylate toxicity, hemodialysis should be considered as part of management, as this is associated with decreased mortality. Salicylates are common substances that can be purchased... read more
Evidence-based Recommendations on the Use of Intravenous Lipid Emulsion Therapy in Poisoning
Although intravenous lipid emulsion (ILE) was first used to treat life-threatening local anesthetic (LA) toxicity, its use has expanded to include both non-local anesthetic (non-LA) poisoning and less severe manifestations... read more
