Can this patient be safely weaned from RRT?

The timing of initiation of renal replacement therapy (RRT) in the critically ill with acute kidney injury (AKI) has been widely studied and discussed in detail recently. However, there is limited information and few recommendations... read more

Robot aims to zap out ICU infections

Hospital workers are constantly cleaning rooms to avoid Hospital Acquired Infections at Hunterdon Medical Center, but now a robot will be working to do the dirty work. In July, the hospital purchased a $100,000 Xenex... read more

Opioid use to worse outcomes in C. difficile

A study presented at the World Congress of Gastroenterology found that patients being prescribed opioids who also have Clostridium difficile infections (CDIs) have higher peak white blood cell counts, higher creatinine elevations,... read more

Early Oseltamivir Therapy Improves the Outcome in Critically Ill with Influenza

This real-life study emphasizes oseltamivir efficacy on in-hospital outcome when administrated within 2 days of the onset of symptoms. Even if physicians' awareness of the influenza disease has been undeniably enhanced... read more

2B4-Mediated Coinhibition of CD4+ T Cells Underlies Mortality in Experimental Sepsis

Sepsis is a leading cause of death in the United States, but the mechanisms underlying sepsis-induced immune dysregulation remain poorly understood. 2B4 (CD244, SLAM4) is a cosignaling molecule expressed predominantly on... read more

Doctors Feel What It’s Like to Be in the ICU

Immersive art project lets Mount Sinai staff hear noises and feel confined like intensive-care brain trauma patients; a new view of treating unconscious patients.... read more

Hospital admissions for sepsis jump 89% in Pennsylvania

The number of Lehigh Valley hospital admissions for sepsis, an increasingly prevalent life-threatening complication from infections, increased by 69 percent over eight years, according to a state report released Wednesday.... read more

Addressing Antimicrobial Resistance and Stewardship

Antimicrobial-resistant infections affect more than 2 million people annually in the United States alone, accounting for an estimated 23 000 deaths and estimated economic costs of $55 billion. Recent projections suggest... read more

Cytomegalovirus infection in immunocompetent critically ill adults

Some studies have demonstrated an association between Cytomegalovirus (CMV) disease and increased mortality rates, prolonged intensive care unit and hospital length of stay, prolonged mechanical ventilation, and nosocomial... read more

First Year in Care Critical to Retention, HIV Suppression

A previous study showed that the rate of long-term mortality more than doubled when patients missed visits in the first year after diagnosis.... read more

Principles of Antimicrobial Stewardship for Bacterial and Fungal Infections in ICU

Selecting antimicrobial therapy for suspected infection in critically ill patients is an important decision-making process for intensivists. In this current age of multi-drug-resistant organisms (MDROs), intensivists must... read more

Antiseptic baths to prevent infections deemed effective for long-term use

Long-term use antiseptic soap in bathing critically ill patients to prevent healthcare-associated infections (HAIs) did not cause high levels of resistance in bacteria on the patients' skin.... read more

Sepsis – Explained in 3 Minutes

Sepsis is an emergency, striking about 30 million people every year, killing 6 to 9 million of them. Learn what sepsis is, and how to identify and treat it in this 3-min video. Please share with your loved ones - it could... read more

Association Between mRNA Expression of CD74 and IL10 and Risk of ICU-acquired Infections

Intensive care unit (ICU)-acquired infections (IAI) result in increased hospital and ICU stay, costs and mortality. To date, no biomarker has shown sufficient evidence and ease of application in clinical routine for the identification... read more

Raising Sepsis Awareness

Most recent parody created by ILAS (Brazil) aimed at health professionals with English subtitles. Share this video with your multidisciplinary teams because together we can overcome sepsis.... read more

Antibiotic Prescription Fill Rates Declining

Since 2010, antibiotic prescription rates in the U.S. have been declining among the commercially insured population, falling 9 percent during this period. In this report, the Blue Cross Blue Shield Association, in partnership... read more

Sepsis Awareness Month

September is Sepsis Awareness month. To mark the occasion we invited Marijke Vroomen Durning, Director of Content at Sepsis Alliance, to tell us more about Sepsis, the organization’s work, and the importance of raising... read more

FDA Approves ‘living drug’ to Cure Cancer

FDA has approved the first treatment to redesign immune system so it attacks the cancer cells. Kymriah therapy, which leaves 83% of people free of a type of blood cancer, costs about $475,000 and was developed by Novartis.... read more

Are contact isolation precautions (CP) necessary when caring for patients infected or colonized with endemic MRSA or VRE?

Researchers from the University of Nebraska Medical Center Division of Infectious Diseases and Nebraska Medicine Department of Infection Control and Epidemiology recently published results from a two-year observational study... read more

Acetaminophen in the ICU: Mixed Findings

Does having a fever help fight infection? Patients who got acetaminophen to relieve fever while in intensive care units did about as well as patients who got a placebo when it came to mortality. But in a puzzling finding,... read more

Septic shock with no diagnosis at 24 hours: a pragmatic multicenter prospective cohort study

The lack of a patent source of infection after 24 hours of management of shock considered septic is a common and disturbing scenario. A multicenter observational cohort study in ten intensive care units (ICU) in France.... read more

Restricting volumes of resuscitation fluid in adults with septic shock after initial management

A protocol restricting resuscitation fluid successfully reduced volumes of resuscitation fluid compared with a standard care protocol in adult ICU patients with septic shock.... read more