Sepsis Around the Cradle of Humankind

Sepsis Around the Cradle of Humankind

While representing the cutting edge of civilization everywhere, mothers and their newborn infants are a population particularly vulnerable to sepsis.1 By recognizing the importance of antiseptic prophylaxis (handwashing),... read more

Drug-resistant Superbug Spreading in Hospitals

Drug-resistant Superbug Spreading in Hospitals

A superbug resistant to all known antibiotics that can cause "severe" infections or even death is spreading undetected through hospital wards across the world, scientists in Australia warned on Monday. Researchers at the... read more

MRSA Protocols – Methods in Molecular Biology

MRSA Protocols – Methods in Molecular Biology

Presenting the most up-to-date techniques for the detection, genotyping, and investigation of methicillin-resistant S. aureus (MRSA), this second edition of Methicillin-Resistant Staphylococcus aureus (MRSA) Protocols collects... read more

Trends in Visits to Acute Care Venues for Treatment of Low-Acuity Conditions

Trends in Visits to Acute Care Venues for Treatment of Low-Acuity Conditions

From 2008 to 2015, total acute care utilization for the treatment of low-acuity conditions and associated spending per member in the United States increased, and utilization of non-ED acute care venues increased rapidly.... read more

New antibiotics and antimicrobial combination therapy for the treatment of gram-negative bacterial infections

New antibiotics and antimicrobial combination therapy for the treatment of gram-negative bacterial infections

Only few new molecules have an adequate activity against MDR gram-negative pathogens, especially carbapenemase-producer strains. Among these, ceftozolane/tazobactam has been recently approved for clinical use. Other compounds,... read more

Diagnosis and Treatment of Clostridium difficile Infection

Diagnosis and Treatment of Clostridium difficile Infection

Clostridium difficile infection (CDI) is less common than antibiotic-associated diarrhea and irritable bowel syndrome. There is significant concern about overdiagnosis and subsequent overtreatment of CDI with increasing use... read more

Comparison of Complication Rates of Central Venous Catheters Versus Peripherally Inserted Central Venous Catheters in Pediatric Patients

Comparison of Complication Rates of Central Venous Catheters Versus Peripherally Inserted Central Venous Catheters in Pediatric Patients

Rates of central line–associated bloodstream infection and venous thromboembolism were higher in hospitalized pediatric patients with peripherally inserted central catheters as compared to central venous catheters. Our... read more

Probiotic and Synbiotic Therapy in the Critically Ill

Probiotic and Synbiotic Therapy in the Critically Ill

Recent medical history has largely viewed our bacterial symbionts as pathogens to be eradicated rather than essential partners in optimal health. However, one of the most exciting scientific advances in recent years has been... read more

Intensive care in severe malaria: Report from the task force on tropical diseases by the WFSICCM

Intensive care in severe malaria: Report from the task force on tropical diseases by the WFSICCM

Severe malaria is common in tropical countries in Africa, Asia, Oceania and South and Central America. It may also occur in travelers returning from endemic areas. Plasmodium falciparum accounts for most cases, although P... read more

Effect of procalcitonin-guided antibiotic treatment on clinical outcomes in ICU patients with infection and sepsis patients

Effect of procalcitonin-guided antibiotic treatment on clinical outcomes in ICU patients with infection and sepsis patients

Procalcitonin-guided antibiotic treatment in ICU patients with infection and sepsis patients results in improved survival and lower antibiotic treatment duration. Mortality in the 2252 procalcitonin-guided patients was significantly... read more

Dying as a Pathway to Death in Sepsis

Dying as a Pathway to Death in Sepsis

Mortality from sepsis remains high, with at least 270,000 deaths annually in the United States and more than 5 million deaths worldwide. Despite increasing understanding of the pathophysiology of sepsis, outside of targeted... read more

NIH Researchers Discover Highly Infectious Vehicle for Transmission of Viruses Among Humans

NIH Researchers Discover Highly Infectious Vehicle for Transmission of Viruses Among Humans

Researchers have found that a group of viruses that cause severe stomach illness — including the one famous for widespread outbreaks on cruise ships — get transmitted to humans through membrane-cloaked "virus clusters"... read more

Timing of Infectious Disease Clinical Rotation Is Associated With Infectious Disease Fellowship Application

Timing of Infectious Disease Clinical Rotation Is Associated With Infectious Disease Fellowship Application

During a 7-year period, those interns randomly assigned to rotate on ID in the first 6 months of their intern year were more likely to become future ID applicants. This supports prior self-reported survey data that early... read more

How You Can Protect Your Parent From Delirium

How You Can Protect Your Parent From Delirium

Unlike dementia, which is constant and gets progressively worse, delirium tends to come and go, fluctuating even in the course of a day. The symptoms are transitory, yet for people who develop delirium, it can be the start... read more