Tag: inflammation
The Post-injury Inflammatory State and the Bone Marrow Response to Anemia
The pathophysiology of persistent injury-associated anemia is incompletely understood, and human data are sparse. Objective: To translate pre-clinical findings by characterizing injury-associated anemia among critically ill... read more
Temporal Biomarker Profiles and Their Association with ICU Acquired Delirium
While there are differences in markers (adiponectin and several brain proteins) between patients with and without delirium, the development of delirium is not preceded by a change in the biomarker profile of inflammatory... read more
The Ten Pitfalls of Lactate Clearance in Sepsis
Clearance is the removal of a substance from blood, expressed as a volume (milliliters) over time (minutes). However, changes in lactate levels are the sum of ongoing production and removal from the blood by excretion (e.g.,... read more
Can A Cocktail Of Vitamins And Steroids Cure A Major Killer In Hospitals?
Scientists have launched two large studies to test a medical treatment that, if proven effective, could have an enormous impact on the leading cause of death in American hospitals. The treatment is aimed at sepsis, a condition... read more
Human limb skeletal muscle wasting and architectural remodeling during five to ten days intubation and ventilation in critical care
Using ultrasound, we have been able to demonstrate that muscle thickness and architecture of vastus lateralis undergo rapid changes during the early phase of admission to a critical care environment. Muscle loss in critically... read more
ICU-Acquired Weakness and Recovery from Critical Illness
Kress and Hall propose that rehabilitation of critically ill patients should begin in the ICU. The authors name sepsis, systemic inflammation, multiorgan failure, hyperglycemia, glucocorticoid use, and female sex as risk... read more
The Inflammatory Response to ECMO
Extracorporeal membrane oxygenation (ECMO) is a technology capable of providing short-term mechanical support to the heart, lungs or both. Over the last decade, the number of centres offering ECMO has grown rapidly. At the... read more
Prompt Administration of Antibiotics and Fluids in the Treatment of Sepsis
We conclude that antibiotic therapy is highly time sensitive, and efforts should be made to deliver this critical therapy as early as possible in sepsis, perhaps extending into the first point of medical contact outside the... read more
Evaluation of early administration of simvastatin in the prevention and treatment of delirium in critically ill patients undergoing mechanical ventilation
Delirium in critically ill patients is associated with poor clinical outcomes. Neuroinflammation might be an important mechanism in the pathogenesis of delirium, and since simvastatin has anti-inflammatory properties it might... read more
Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommended enteral and parenteral intakes
Critically ill patients have low vitamin C concentrations despite receiving standard ICU nutrition. Septic shock patients have significantly depleted vitamin C levels compared with non-septic patients, likely resulting from... read more
Optimal Approach to Mechanical Ventilation After Cardiac Arrest
Return of spontaneous circulation after cardiac arrest results in a systemic inflammatory state called the post-cardiac arrest syndrome (PCAS), characterised by oxidative stress, coagulopathy, neuronal injury, and organ dysfunction.... read more
Dr. Paul Wischmeyer Brings Humanity To Medicine
Dr. Paul Wischmeyer's journey to becoming an internationally-renowned critical care and perioperative nutrition researcher and clinician began at the age of 15 when a bout of strep throat and a prescription for antibiotics... read more
Platelets and Multi-Organ Failure in Sepsis
Platelets have received increasing attention for their role in the pathophysiology of infectious disease, inflammation, and immunity. In sepsis, a low platelet count is a well-known biomarker for disease severity and more... read more
Adverse Effects of Crystalloid and Colloid Fluids
Volume therapy can be managed according to the fluid balance method, the outcome-guided method, or the goal-directed method. One reason why fluid is needed is that anesthesia disrupts the normal autonomic control of the circulation,... read more
Cellular Immunotherapy for Septic Shock
The infusion of freshly cultured allogenic bone marrow derived MSCs into participants with septic shock up to a dose of 3 million cells per kg (250 million cells) appears safe. Ages of participants in the interventional versus... read more
Metformin and Aspirin Potential Key in Treating Inflammatory Diseases
Ingredient in aspirin combined with popular diabetes drug can turn off faulty protein that plays a key role in inflammatory diseases, such as rheumatoid arthritis. ... read more
Drink Coffee and Live Longer: Cohort Study
A multinational cohort study on coffee drinking and mortality in 10 European countries. Coffee drinking was associated with reduced risk for death from various causes. This relationship did not vary by country. 521, 330 people... read more
New Institute to Focus on Immune System
Vanderbilt University Medical Center (VUMC) is launching a new institute to coordinate initiatives among the rapidly evolving disciplines of infection biology, immunology and inflammatory diseases. The Vanderbilt Institute... read more
Sevoflurane for Sedation in Acute Respiratory Distress Syndrome. A Randomized Controlled Pilot Study
Sevoflurane improves gas exchange, and reduces alveolar edema and inflammation in preclinical studies of lung injury, but its therapeutic effects have never been investigated in acute respiratory distress syndrome (ARDS).... read more
Lung Microbiome: Key to Respiratory Ills?
Recently, JAMA discussed this research and its potential clinical applications with 2 experts on the front lines, Jack Gilbert, PhD, a microbial ecologist at the University of Chicago and director of its new Microbiome Center... read more
The Prevalence of Acute Critical Neurological Disease in Children
Neurologic insults are a significant pediatric international health issue. They are frequent and contribute substantial morbidity and mortality. These data suggest a need for an increased focus on acute critical neurologic... read more
