Tag: lungs
TAC on Computed Tomography and the Risk of COPD Progression
Total Airway Count (TAC) may reflect the airway-related disease changes that accumulate in the “quiet” zone in early/mild Chronic Obstructive Pulmonary Disease (COPD), indicating that TAC acquired with commercially available... read more
Calcium induces chronic lung infections
Researchers have now discovered that calcium induces the switch from acute to chronic infection. One of the most serious pathogens is the bacterium Pseudomonas aeruginosa, which frequently causes hospital infections and is... read more
Higher PEEP versus Lower PEEP Strategies for Patients with ARDS
Use of higher positive end-expiratory pressure (PEEP) is unlikely to improve clinical outcomes among unselected patients with ARDS. We identified eight randomized trials comparing higher versus lower PEEP strategies, enrolling... read more
Ultrasound-guided Mechanical Ventilation
Point-of-care ultrasound (POCUS) is now a tool used worldwide, integrating clinical assessment of the critically ill. In this review, we focus on lung, diaphragm and cardiac ultrasound in the management of the mechanically... read more
Aerosol Delivery During Invasive Mechanical Ventilation
Lung deposition was lower than 20% of nominal dose delivered with nebulizers and mostly occurred in proximal airways. Further studies are needed to link substantial concentrations of antibiotics in infected pulmonary fluids... read more
The World Day of the Critical Lung Event
On November 17th 2017, the first edition of "The World Day of the Critical Lung" will be held. It will be an online, global, free, bilingual (Spanish and English) participatory and non-profit event organized by the Pan American... read more
4m-gait speed test reliable/valid physical function measure in ARDS survivors
The 4-m gait speed is a reliable, valid, and responsive measure of physical function in acute respiratory distress syndrome survivors. The estimated minimal important difference will facilitate sample size calculations for... read more
The Overlaps of Asthma or COPD with OSA
Asthma, chronic obstructive pulmonary disease (COPD) and obstructive sleep apnoea (OSA) are the most common respiratory disorders worldwide. Given demographic and environmental changes, prevalence for each is likely to increase. Some... read more
Utility and Diagnostic Accuracy of Bedside Lung Ultrasonography During MET
Lung ultrasonography can be rapidly performed in the majority of patients with MET activation for respiratory deterioration. As an independent diagnostic test, lung ultrasonography is non-inferior to the medical emergency... read more
Acute Lung Failure – Our Evolving Understanding of ARDS
Since Laennec described the gross pathology of idiopathic anasarca of the lungs in 1821, mortality due to the acute respiratory distress syndrome has been vastly reduced. Yet the poor subsequent condition of ARDS survivors... read more
Frequency of Exacerbations in Patients with COPD
Present treatment strategies to stratify exacerbation risk in patients with chronic obstructive pulmonary disease (COPD) rely on a history of two or more events in the previous year. We aimed to understand year to year variability... read more
A population-based cohort study of rheumatoid arthritis-associated interstitial lung disease
ILD is a serious complication in RA, with a significantly increased mortality compared with a large matched cohort of RA comparisons without ILD. Mortality risks were assessed using Kaplan-Meier mortality curves, and hazard... read more
Volume responsiveness and volume tolerance: a conceptual diagram
So I know I've be-laboured the point about the difference between volume responsiveness (i.e. will there be significant increase in cardiac output with volume infusion) and volume tolerance (is the volume I am considering... read more
Lung Microbiome: Key to Respiratory Ills?
Recently, JAMA discussed this research and its potential clinical applications with 2 experts on the front lines, Jack Gilbert, PhD, a microbial ecologist at the University of Chicago and director of its new Microbiome Center... read more
Utility and diagnostic accuracy of bedside lung ultrasonography during MET activations for respiratory deterioration
We investigated the feasibility and diagnostic accuracy of lung ultrasonography during medical emergency team (MET) activations for respiratory deterioration. The ultrasound exam was completed in 49/50 (98%) patients enrolled... read more
Opening pressures and atelectrauma in ARDS
Data show that the prerequisites of the open lung strategy are not satisfied using PEEP up to 15 cmH2O and plateau pressure up to 30 cmH2O. For an effective open lung strategy, higher pressures are required. Therefore,... read more
Effects of Neuromuscular Blockers on Transpulmonary Pressures in Moderate to Severe ARDS
Thirty patients were included, 24 with moderate ARDS and 6 with severe ARDS. NMBA infusion was associated with an improvement in oxygenation in both moderate and severe ARDS, accompanied by a decrease in both plateau pressure... read more
