Colchicine, the only effective oral medication for treating non-hospitalized COVID-19 patients

The Montreal Heart Institute announced COLCORONA clinical trial has provided clinically persuasive results of colchicine's efficacy to treat COVID-19. The study results show that colchicine reduces the risk of death or... read more

De Novo Renal Failure and Clinical Outcomes of Patients With Critical COVID-19

This case series concludes that respiratory failure conveys significant mortality risk in patients with coronavirus disease 2019 and that survival with concomitant renal failure is rare. This is a case series of patients... read more

COVID-19 Pneumonia: Typical or Atypical Form of ARDS?

Evidence-based guidelines can never help a doctor resolve whether a patient is best managed by inserting an endotracheal tube or avoiding its use. That decision is based on clinical judgment, gestalt, and tacit knowledge.... read more

Delirium Prevalence and Risk Factors for Critically Ill COVID-19 Patients

Acute brain dysfunction was highly prevalent and prolonged in critically ill patients with COVID-19. Benzodiazepine use and lack of family visitation were identified as modifiable risk factors for delirium, and thus these... read more

Estimate Artery Occlusion Pressure in Critically Ill Patients Under Mechanical Ventilation Using Doppler Echocardiography

In mechanically ventilated critically ill patients, Doppler transthoracic echocardiography indices are highly specific but not sensitive to estimate pulmonary artery occlusion pressure. Transmitral early velocity wave... read more

Time-Controlled Adaptive Ventilation Versus Volume-Controlled Ventilation in Experimental Pneumonia

In the model of pneumonia used herein, at the same tidal volume and mean airway pressure, time-controlled adaptive ventilation, compared with volume-controlled ventilation, was associated with less lung damage and bacteremia... read more

The Ventilator Book

If you need something that teaches you both the concepts of mechanical ventilation and how to manage patients with respiratory failure, this is the book for you. The Ventilator Book is written to be read in the ICU or Emergency... read more

The Ventilator Book

Outcomes Associated with the Use of Renin-Angiotensin-Aldosterone System Blockade in Hospitalized Patients with COVID-19 Infection

Use of ACEI or ARBs prior to hospitalization was not associated with adverse outcomes in COVID-19 and the therapeutic benefits of continuing ACEI or ARB in hospitalized patients with COVID-19 was not offset by adverse outcomes. Data... read more

Doppler Echocardiographic Indices in Critically Ill Patients Under Mechanical Ventilation

Doppler Echocardiographic Indices Are Specific But Not Sensitive to Predict Pulmonary Artery Occlusion Pressure in Critically Ill Patients Under Mechanical Ventilation. The objective of this study was to prospectively... read more

Weaning the patient: between protocols and physiology

Ventilator weaning forms an integral part in critical care medicine and strategies to shorten duration are rapidly evolving alongside our knowledge of the relevant physiological processes. The purpose of the current review... read more

Clinical characteristics of critically ill patients with COVID-19

In this study of critical patients infected by SARS-CoV-2 in a high-complexity hospital, the majority were comorbid elderly men, a large percentage required invasive mechanical ventilation, and ICU mortality was 25%. Design... read more

Development and assessment of the performance of a shared ventilatory system

Using standard clinical components, a system of shared ventilation consisting of two ventilatory limbs was assembled and connected to a single ventilator. Individual monitors for each circuit were developed using widely available... read more

What’s new about pulmonary hyperinflation in mechanically ventilated critical patients

Pulmonary hyperinflation is the increase in the relaxation volume of the respiratory system at the end of a tidal expiration (end-expiratory volume). This can occur due to a number of factors, acting alone or in combination,... read more

Mechanical Ventilators for Non-invasive Ventilation

This book analyzes and describes the whole spectrum of technical elements related with non-invasive mechanical ventilators technologies, ventilator modes and complementary technologies for correct interpretation and clinical... read more

Mechanical Ventilators for Non-invasive Ventilation

Airway closure, more harmful than atelectasis in intensive care?

Since the mid-1980s, atelectasis has been demonstrated during anesthesia in lung healthy subjects and in intensive care patients suffering from acute respiratory failure and requiring ventilator support. In the latter... read more

Epidemiology of Invasive Pulmonary Aspergillosis Among COVID-19 Intubated Patients

We found a high incidence of CAPA among critically ill COVID-19 patients and that its occurrence seems to change the natural history of disease. A total of 108 patients were enrolled. Prospective, multicentre study... read more

Utility of RV Remodeling Over Risk Stratification in COVID-19

This study contributes to the growing body of literature illustrating the adverse prognostic implications of RV dilation and dysfunction in the setting of severe COVID-19. Mechanistic explanations for RV failure in this population... read more

Some Signs of Recovery From Severe COVID-19 Lung Damage

In two early studies, researchers said some patients showed signs of healing just weeks after leaving the hospital. Lingering shortness of breath and diminished stamina have dogged many COVID patients whose lungs were... read more

Outcomes of Patients Requiring Prolonged Acute vs. Short-Term Mechanical Ventilation

Over one-third of all hospitalized patients on mechanical ventilation require it for greater than or equal to 4 days. Prolonged acute mechanical ventilation patients exhibit a higher burden of both chronic and acute illness... read more

Monitoring of the Adult Patient on VA ECMO

Venoarterial extracorporeal membrane oxygenation (VA ECMO), a form of mechanical circulatory support, had its origins in the operating room as cardiopulmonary bypass and has evolved for use in the intensive care unit and... read more

Efficacy and Safety of a Paired Sedation and Ventilator Weaning

The purpose of this study is to determine the impact of a new RN/RRT (Registered Nurse/Registered Respiratory Therapist) directed 2-step protocol to wean patients off of a ventilator. This protocol involves daily attempts... read more

Early Arterial Embolization and Mortality in Mechanically Ventilated Patients With Hemoptysis

The objective of this study was to clarify whether early intervention by arterial embolization reduced mortality in mechanically ventilated patients with hemoptysis. The results show that early intervention by arterial... read more