Prone Positioning in Non-intubated Patients with COVID-19

Prone Positioning in Non-intubated Patients with COVID-19

As the COVID-19 pandemic has put severe stress and strain on the capacity of hospitals around the world, concerted efforts have been made to evaluate therapeutics aimed at preventing the need for mechanical ventilation. The... read more

ICU Trends for Patients with COVID-19 in England, Wales and Northern Ireland

ICU Trends for Patients with COVID-19 in England, Wales and Northern Ireland

Observed trends suggest opposing effects of ICU strain and clinical learning. Further investigation is needed to identify modifiable system factors that could alleviate strain in future epidemics and changes in clinical practice... read more

Efficacy and Safety of a Paired Sedation and Ventilator Weaning Protocol in ICU

Efficacy and Safety of a Paired Sedation and Ventilator Weaning Protocol in ICU

Approaches to removal of sedation and mechanical ventilation for critically ill patients vary widely. Our aim was to assess a protocol that paired spontaneous awakening trials (SATs)—ie, daily interruption of sedatives—with... read more

Automated vs. Conventional Ventilation in the ICU

Automated vs. Conventional Ventilation in the ICU

Automated ventilation (AV) appears to reduce the incidence and severity of blood oxygen desaturation during daily nursing procedures (DNPs) in comparison to Conventional Ventilation (CV). Of the 265 included patients,... read more

ICU Doctor Creates App to Help Patients on Ventilators Communicate Faster

ICU Doctor Creates App to Help Patients on Ventilators Communicate Faster

ICU Doctor Chandar Abboy and his partner came up with a way to give a voice to the voiceless. The app called “Yo Doc” allows patients on ventilators to better communicate their needs and feelings. Dr. Abboy says this... read more

Association Between Anxiety and New Organ Failure, Independently of Critical Illness Severity and Respiratory Status

Association Between Anxiety and New Organ Failure, Independently of Critical Illness Severity and Respiratory Status

Moderate to severe anxiety at ICU admission is associated with early occurrence of new organ failure in critically ill patients, independently of respiratory status and severity of critical illness. The causality link could... read more

COVID-19 Drug Treatments: Living Systematic Review and Network Meta-analysis

COVID-19 Drug Treatments: Living Systematic Review and Network Meta-analysis

Glucocorticoids probably reduce mortality and mechanical ventilation in patients with COVID-19 compared with standard care. The effectiveness of most interventions is uncertain because most of the randomised controlled trials... read more

Working in ICU is like Flying a Plane: The Secret World of Intensive Care

Working in ICU is like Flying a Plane: The Secret World of Intensive Care

Stepping on to the ICU during this period was like entering another world. In a way intensive care has always seemed like a place removed from life outside said Mike Brunner, an intensive care doctor at Northwick Park hospital... read more

Respiratory Strategies for Patients with Suspected or Proven COVID-19 Respiratory Failure

Respiratory Strategies for Patients with Suspected or Proven COVID-19 Respiratory Failure

The trial objective is to determine if Continuous Positive Airway Pressure (CPAP) or High-Flow Nasal Oxygen (HFNO) is clinically effective compared to standard oxygen therapy in patients with confirmed or suspected COVID-19. The... read more

Development of Persistent Respiratory Morbidity in Previously Healthy Children After ARF

Development of Persistent Respiratory Morbidity in Previously Healthy Children After ARF

Persistent respiratory morbidity develops in up to potentially 44% of previously healthy children less than or equal to 24 months old at follow-up after acute respiratory failure (ARF) requiring mechanical ventilation. This... read more

Presence of Genetic Variants Among Young Men With Severe COVID-19

Presence of Genetic Variants Among Young Men With Severe COVID-19

In this case series of 4 young male patients with severe COVID-19, rare putative loss-of-function variants of X-chromosomal TLR7 were identified that were associated with impaired type I and II IFN responses. These preliminary... read more

Risks Of VAP in Patients With Viral ARDS Related or Not To COVID-19

Risks Of VAP in Patients With Viral ARDS Related or Not To COVID-19

In this retrospective case-control study, we have observed a higher prevalence of ventilator-associated pneumonia (VAP) and MDR VAP in C-ARDS as compared with NC-ARDS patients. Further, probably multicenter, research work... read more

Early Prediction of ICU-Acquired Weakness

Early Prediction of ICU-Acquired Weakness

The previously developed prediction model for ICU-AW showed poor performance in a new independent multicenter validation cohort. Model updating methods improved calibration but not discrimination. The newly derived prediction... read more

Why, When, and How to Use Lung Ultrasound During the COVID-19 Pandemic

Why, When, and How to Use Lung Ultrasound During the COVID-19 Pandemic

The COVID-19 pandemic has further highlighted the usefulness of LUS in different clinical scenarios, underlining its advantages in terms of availability, operator- and patient-friendliness, relatively low cost and expertise... read more