Improving Hospital Survival and Reducing Brain Dysfunction at Seven California Community Hospitals

Improving Hospital Survival and Reducing Brain Dysfunction at Seven California Community Hospitals

The evidence-based ABCDEF bundle was successfully implemented in seven community hospital ICUs using an interprofessional team model to operationalize the Pain, Agitation, and Delirium guidelines. Higher bundle compliance... read more

Can probiotics be an alternative to chlorhexidine for oral care in the mechanically ventilated patient?

Can probiotics be an alternative to chlorhexidine for oral care in the mechanically ventilated patient?

In this multicentre study, we could not demonstrate any difference between Lp299 and CHX used in oral care procedures regarding their impact on colonisation with emerging potentially pathogenic enteric bacteria in the oropharynx... read more

Carbonic anhydrase inhibitors in patients with respiratory failure and metabolic alkalosis

Carbonic anhydrase inhibitors in patients with respiratory failure and metabolic alkalosis

In patients with respiratory failure and metabolic alkalosis, carbonic anhydrase inhibitor therapy may have favorable effects on blood gas parameters. In mechanically ventilated patients, carbonic anhydrase inhibitor therapy... read more

Identifying associations between diabetes and ARDS in patients with AHRF

Identifying associations between diabetes and ARDS in patients with AHRF

Diabetes mellitus is a common co-existing disease in the critically ill. Diabetes mellitus may reduce the risk of acute respiratory distress syndrome (ARDS), but data from previous studies are conflicting. The objective of... read more

Electrical Impedance Tomography in ARDS

Electrical Impedance Tomography in ARDS

Acute respiratory distress syndrome (ARDS) is a clinical entity that acutely affects the lung parenchyma, and is characterized by diffuse alveolar damage and increased pulmonary vascular permeability. Currently, computed... read more

Patterns of Early Crystalloid Resuscitation Provided to Sepsis and Septic Shock Patients

Patterns of Early Crystalloid Resuscitation Provided to Sepsis and Septic Shock Patients

Patterns and Outcomes Associated With Timeliness of Initial Crystalloid Resuscitation in a Prospective Sepsis and Septic Shock Cohort. Crystalloid was initiated significantly later with comorbid heart failure and renal failure,... read more

Imaging platform captures hard-to-track bacterial lung infections in real time

Imaging platform captures hard-to-track bacterial lung infections in real time

Ahsan Akram and colleagues have created a fluorescent imaging probe that can quickly and accurately detect hard-to-trace Gram-negative bacteria (one of the major bacterial groups) in human lungs within minutes. Their first-in-human... read more

Dopamine Antagonists in ICU Delirium

Dopamine Antagonists in ICU Delirium

Perhaps the most vexing problem in a patient in an intensive care unit (ICU) is an unexpected change in mental status. Historically, "acute encephalopathy" was the term used to encompass such alterations, but "delirium" is... read more

RRT Board Exam: Mechanical Ventilation

RRT Board Exam: Mechanical Ventilation

There’s nothing better than feeling confident and relaxed on exam day! Knowing that years of late night study sessions and unpaid clinical rotations are coming to an end just feels….well, absolutely fantastic! Of course,... read more

Initial Trophic vs Full Enteral Feeding in Patients With Acute Lung Injury

Initial Trophic vs Full Enteral Feeding in Patients With Acute Lung Injury

In patients with acute lung injury, compared with full enteral feeding, a strategy of initial trophic enteral feeding for up to 6 days did not improve ventilator-free days, 60-day mortality, or infectious complications but... read more

Decontamination Strategies and Bloodstream Infections With Antibiotic-Resistant Microorganisms in Ventilated Patients

Decontamination Strategies and Bloodstream Infections With Antibiotic-Resistant Microorganisms in Ventilated Patients

In this cluster randomized multicenter study in 13 European ICUs, decontamination strategies with either antibiotics (SDD or SOD) or CHX mouthwash were not associated with reductions in ICU-acquired BSI with MDRGNB, nor mortality,... read more

Decontamination of Oral or Digestive Tract for Patients in the ICU

Decontamination of Oral or Digestive Tract for Patients in the ICU

The study by Wittekamp and colleagues in this issue of JAMA evaluating strategies for decontamination of mechanically ventilated patients in the intensive care unit (ICU) fills an important gap in the evidence regarding these... read more

Effect of Dexmedetomidine on Mortality and Ventilation in Sepsis Patients

Effect of Dexmedetomidine on Mortality and Ventilation in Sepsis Patients

Dexmedetomidine provides sedation for patients undergoing ventilation; however, its effects on mortality and ventilator-free days have not been well studied among patients with sepsis. This randomized clinical trial compares... read more

Implementing a bedside assessment of respiratory mechanics in patients with ARDS

Implementing a bedside assessment of respiratory mechanics in patients with ARDS

Implementing a systematic respiratory mechanics test leads to frequent individual adaptations of ventilator settings and allows improvement in oxygenation indexes and reduction of the risk of overdistention at the same time.... read more

Communicating with Conscious and Mechanically Ventilated Critically Ill Patients

Communicating with Conscious and Mechanically Ventilated Critically Ill Patients

Ventilator-dependent patients in the ICU often experience difficulties with one of the most basic human functions, namely communication, due to intubation. Although various assistive communication tools exist, these are infrequently... read more

Mechanical Ventilation/Ventricular Assist Devices, An Issue of Critical Care Clinics

Mechanical Ventilation/Ventricular Assist Devices, An Issue of Critical Care Clinics

This issue of Critical Care Clinics focuses on Mechanical Ventilation and Ventricular Assist Devices, with topics including: Targeted management approach to cardiogenic shock; Prevention and treatment of right heart failure... read more

Navigating Medical Emergencies – An interactive guide to patient management

Navigating Medical Emergencies – An interactive guide to patient management

This free eBook presents emergent clinical situations and the core tasks required of healthcare professionals needing to recognize, navigate and safely manage them. It's really about how to perform the ABCs while protecting... read more