Antifungal Treatment in the ICU

Antifungal Treatment in the ICU

Invasive fungal infections (IFIs) are a major cause of morbidity and mortality in critically ill patients. Almost 80% of IFIs are due to Candida spp., which are the third most common isolated microorganisms in the intensive... read more

Mortality and Morbidity in Acutely Ill Adults Treated with Liberal vs. Conservative Oxygen Therapy

Mortality and Morbidity in Acutely Ill Adults Treated with Liberal vs. Conservative Oxygen Therapy

In acutely ill adults, high-quality evidence shows that liberal oxygen therapy increases mortality without improving other patient-important outcomes. Supplemental oxygen might become unfavourable above an SpO2 range of 94-96%.... read more

Intensive care in severe malaria: Report from the task force on tropical diseases by the WFSICCM

Intensive care in severe malaria: Report from the task force on tropical diseases by the WFSICCM

Severe malaria is common in tropical countries in Africa, Asia, Oceania and South and Central America. It may also occur in travelers returning from endemic areas. Plasmodium falciparum accounts for most cases, although P... read more

Natriuretic Peptides: A Role in Early Septic Acute Kidney Injury?

Natriuretic Peptides: A Role in Early Septic Acute Kidney Injury?

Acute kidney injury (AKI) is a common complication of critical illness and is associated with significant morbidity, mortality, and financial cost. Sepsis is the leading association of acute kidney injury in the intensive... read more

Functional Status Change Among Children With ECMO to Support Cardiopulmonary Resuscitation in a Pediatric Cardiac ICU

Functional Status Change Among Children With ECMO to Support Cardiopulmonary Resuscitation in a Pediatric Cardiac ICU

This is the first extracorporeal cardiopulmonary resuscitation report to examine changes in Functional Status Scale from admission (baseline) to discharge as a measure of overall functional outcome. Half of surviving patients... read more

Providing Psychological Support to People in Intensive Care

Providing Psychological Support to People in Intensive Care

The Provision Of Psychological support to People in Intensive Care (POPPI) psychological intervention to reduce acute patient stress in critical care and prevent future psychological morbidity was feasible and acceptable.... read more

Mitochondrial Function in Sepsis

Mitochondrial Function in Sepsis

The authors were tasked with developing five specific questions regarding mitochondrial function in sepsis within the context of the Acute Dialysis Quality Initiative 14 (ADQI XIV) meeting held in Bogotá, Colombia, in late... read more

Collective Quality Improvement in the Pediatric Cardiology Acute Care Unit

Collective Quality Improvement in the Pediatric Cardiology Acute Care Unit

Collaborative quality improvement and learning networks have amended healthcare quality and value across specialities. Motivated by these successes, the Pediatric Acute Care Cardiology Collaborative (PAC3) was founded in... read more

Peer Support in Critical Care

Peer Support in Critical Care

Peer support appeared to reduce psychologic morbidity and increase social support. The evidence for peer support in critically ill populations is limited. There is a need for well-designed and rigorously reported research... read more

The Relationship Between ICU Hypotension and In-hospital Mortality and Morbidity in Septic Patients

The Relationship Between ICU Hypotension and In-hospital Mortality and Morbidity in Septic Patients

Current guidelines recommend maintaining a mean arterial pressure (MAP)≥ 65 mmHg in septic patients. However, the relationship between hypotension and major complications in septic patients remains unclear. We, therefore,... read more

Sepsis-3, a New Definition. Solutions or New Problems?

Sepsis-3, a New Definition. Solutions or New Problems?

Before we can discuss the "Sepsis-3" definitions, we need to look back at the history of Sepsis definitions, and what the rationale was leading the authors to create a new definition. Below is a brief, albeit non-exhaustive,... read more

The Speed of Sound: A New Measure to Single Out High-Risk PE Patients

The Speed of Sound: A New Measure to Single Out High-Risk PE Patients

Predicting which pulmonary embolism patients will do well with oral anticoagulation and which will decompensate is a bit murky, at best. The treatment of pulmonary embolism (PE) has evolved quite a bit in just the past few... read more

Long-term Recovery Following Critical Illness in an Australian Cohort

Long-term Recovery Following Critical Illness in an Australian Cohort

Almost all data on 5-year outcomes for critical care survivors come from North America and Europe. The aim of this study was to investigate long-term mortality, physical function, psychological outcomes and health-related... read more

Association Between Fluid Balance and Outcomes in Critically Ill Children

Association Between Fluid Balance and Outcomes in Critically Ill Children

Fluid overload is common and is associated with substantial morbidity and mortality in critically ill children. Additional research should now ideally focus on interventions aimed to mitigate the potential for harm associated... read more

Diagnostic Stewardship for Healthcare-Associated Infections

Diagnostic Stewardship for Healthcare-Associated Infections

Healthcare-associated infections (HAIs) are associated with increased morbidity and mortality, prolonged hospital stays, and unnecessary cost. The financial stakes of HAIs for hospitals were underscored in 2008 when the Centers... read more

Characteristics and Outcomes of ICU Survivors

Characteristics and Outcomes of ICU Survivors

A significant number of intensive care unit survivors evaluated 3 months after discharge had psychological, respiratory, motor, and socioeconomic problems; these findings highlight that strategies aimed to assist critically... read more

Social Determinants of Health: A Missing Link in Emergency Medicine Training

Social Determinants of Health: A Missing Link in Emergency Medicine Training

The health of a population depends upon several factors, including disease, public health initiatives, and the social determinants of health (SDH). These factors often converge in the emergency department (ED) where the impact... read more