Dexmedetomidine, Almost As Many Uses As There Are Letters

There is literature to support the use of dexmedetomidine in patients with sympathomimetic toxidrome. It may be a reasonable approach to utilize Dex, with or without a bolus, while closely monitoring these patients in an... read more

Dexmedetomidine, Almost As Many Uses As There Are Letters

High Flow Nasal Cannula: Physiological Effects and Clinical Applications

This book presents the state of the art in high-flow nasal cannula (HFNC), an oxygen therapy technique that has recently proven to be a very promising approach to supporting respiratory function in several medical fields. In... read more

High Flow Nasal Cannula: Physiological Effects and Clinical Applications

Nasal High-Flow Therapy during Neonatal Endotracheal Intubation

Among infants undergoing endotracheal intubation at two Australian tertiary neonatal intensive care units, nasal high-flow therapy during the procedure improved the likelihood of successful intubation on the first attempt... read more

Nasal High-Flow Therapy during Neonatal Endotracheal Intubation

HFNO Alone or Alternating with NIV in ARF Patients

In critically ill immunocompromised patients with acute respiratory failure (ARF), the mortality rate did not differ between HFNO alone and non-invasive ventilation (NIV) alternating with high-flow nasal oxygen (HFNO). However,... read more

HFNO Alone or Alternating with NIV in ARF Patients

Chronic Obstructive Pulmonary Disease, An Issue of Clinics in Chest Medicine

This issue of Clinics in Chest Medicine, guest-edited by Dr. Gerard Criner and Dr. Bartolome Celli, is focused on Chronic Obstructive Pulmonary Disease. Topics discussed in this issue include but are not limited to: COPD... read more

Chronic Obstructive Pulmonary Disease, An Issue of Clinics in Chest Medicine

Optimal Respiratory Support for COVID-19 Patients

Noninvasive respiratory support is an essential component of critical care. Both noninvasive ventilation, with its different interface types and modes (including helmet and face masks), and high-flow nasal oxygen (HFNO) are... read more

Optimal Respiratory Support for COVID-19 Patients

Estimated and Measured Post-tetanic Count Effect

Comparison of two pharmacokinetic–pharmacodynamic models of rocuronium bromide during profound neuromuscular block. Our findings indicate that using plasma concentrations of rocuronium bromide estimated with either of... read more

Estimated and Measured Post-tetanic Count Effect

Non-Invasive Ventilation and Weaning: Principles and Practice, Second Edition

Now in full-colour, this eagerly-anticipated second edition continues to be the most comprehensive resource available on non-invasive ventilation (NIV), both in the hospital and at home. Reflecting a global perspective with... read more

Non-Invasive Ventilation and Weaning: Principles and Practice, Second Edition

Noninvasive Ventilation and Outcomes in Bronchiolitis

In a large cohort of infants at children’s hospitals, noninvasive and invasive ventilation increased significantly from 2010 to 2018. Hospital-level noninvasive ventilation utilization was not associated with a reduction... read more

Noninvasive Ventilation and Outcomes in Bronchiolitis

Facemask vs. Helmet – Noninvasive Ventilation

We use Noninvasive ventilation (NIV) to treat various disease processes, such as acute hypercapnic and hypoxemic respiratory failure, post-extubation failure, and neuromuscular diseases. Data supports NIV use in some conditions,... read more

Facemask vs. Helmet – Noninvasive Ventilation

Breath-holding as a Novel Approach to COVID-19 Risk Stratification

Despite considerable progress, it remains unclear why some patients admitted for COVID-19 develop adverse outcomes while others recover spontaneously. Clues may lie with the predisposition to hypoxemia or unexpected absence... read more

Breath-holding as a Novel Approach to COVID-19 Risk Stratification

Protecting The Injured RV in COVID-19 ARDS

The abnormal interaction between the right ventricle (RV) and pulmonary vasculature in various disease states is associated with adverse clinical outcomes. Impaired RV physiology in acute respiratory distress syndrome (ARDS)... read more

Protecting The Injured RV in COVID-19 ARDS

Non-invasive Respiratory Support and P-SILI in COVID-19

Coronavirus disease 2019 (COVID-19) pneumonia is associated with hypoxemic respiratory failure, ranging from mild to severe. Due to the worldwide shortage of intensive care unit beds, a relatively high number of patients... read more

Non-invasive Respiratory Support and P-SILI in COVID-19

NIV After Early Extubation Reduces Total Days Spent on i-MV

Patients recovering from an episode of hypoxemic acute respiratory failure (hARF) may benefit from a weaning strategy based on early extubation followed by immediate noninvasive ventilation (NIV) application. Compared... read more

NIV After Early Extubation Reduces Total Days Spent on i-MV

Prone Positioning Non-intubated COVID-19 Patients with Severe Hypoxemia Was Safe

In a small sample, prone positioning non-intubated COVID-19 patients with severe hypoxemia was safe; however, many patients did not tolerate prolonged durations. Although patients had improved oxygenation and respiratory... read more

Prone Positioning Non-intubated COVID-19 Patients with Severe Hypoxemia Was Safe

Mechanical Ventilators for Non-invasive Ventilation

This book analyzes and describes the whole spectrum of technical elements related with non-invasive mechanical ventilators technologies, ventilator modes and complementary technologies for correct interpretation and clinical... read more

Mechanical Ventilators for Non-invasive Ventilation

Respiratory Support in Patients with COVID-19

Non-invasive respiratory support could be useful in treating COVID-19-related acute respiratory failure (ARF). A rational use of different techniques (oxygen therapy, CPAP, NIV or HFOT) by a trained pulmonologist could allow... read more

Respiratory Support in Patients with COVID-19

ICU Isolation Hood Decreases Risk of Aerosolization During Noninvasive Ventilation with COVID-19

The treatment of patients with coronavirus disease (COVID-19) needs to take into consideration not only the disease process but also the availability of medical resources and the risks of transmission to healthcare providers.... read more

ICU Isolation Hood Decreases Risk of Aerosolization During Noninvasive Ventilation with COVID-19

A Transdisciplinary COVID-19 Early Respiratory Intervention Protocol

In the days after COVID-19 arrived in our region, there were many such stories of patients sent to the floor from the Emergency Department who were intubated shortly after admission. Many of those patients subsequently... read more

A Transdisciplinary COVID-19 Early Respiratory Intervention Protocol

COVID-19 NIV: Helmet vs Mask

Over the past few weeks there has been a shift in the management of critically ill COVID-19 patients. Many seem to have moved away from an intubate early strategy to the use of high flow nasal cannula (HFNC) and noninvasive... read more

COVID-19 NIV: Helmet vs Mask

Predicting NIV Failure in Hypoxemic Patients

Non-invasive ventilation (NIV) is applied worldwide to patients with hypoxemic respiratory failure. It is often applied as an attempt to avoid invasive mechanical ventilation. However, the application of NIV is often... read more

Predicting NIV Failure in Hypoxemic Patients