Effect of High-Flow Nasal Oxygen vs Standard Oxygen on 28-Day Mortality in Immunocompromised Patients With ARF

Among critically ill immunocompromised patients with acute respiratory failure (ARF), high-flow oxygen therapy did not significantly decrease day-28 mortality compared with standard oxygen therapy. Of 778 randomized patients... read more

Effect of High-Flow Nasal Oxygen vs Standard Oxygen on 28-Day Mortality in Immunocompromised Patients With ARF

High-flow Oxygen Through Nasal Cannula in Acute Hypoxemic Respiratory Failure

In patients with nonhypercapnic acute hypoxemic respiratory failure, treatment with high-flow oxygen, standard oxygen, or noninvasive ventilation did not result in significantly different intubation rates. There was a significant... read more

High-flow Oxygen Through Nasal Cannula in Acute Hypoxemic Respiratory Failure

The EXACT Protocol

The EXACT protocol: a multi-centre, single-blind, randomised, parallel-group, controlled trial to determine whether early oxygen titration improves survival to hospital discharge in adult OHCA patients. This study will determine... read more

The EXACT Protocol

Snapshots of Hemodynamics: An Aid for Clinical Research and Graduate Education

This new edition reviews recent developments in genetics and molecular biology and new noninvasive measurement techniques that have enabled vast improvements in the measurement and understanding of cardiovascular hemodynamics.... read more

Snapshots of Hemodynamics: An Aid for Clinical Research and Graduate Education

Oxygen Therapy in Acute Resuscitation

At present, evidence is lacking to support routine liberal oxygen administration in acutely ill patients and, in most circumstances, a reasonable approach is to titrate supplemental oxygen to achieve an arterial oxygen saturation... read more

Oxygen Therapy in Acute Resuscitation

Noninvasive Ventilation as Acute Therapy

Noninvasive ventilation (NIV) is widely used in ICU patients to treat or to prevent acute respiratory failure (ARF). Whereas its physiological effects are clearly beneficial in hypercapnic patients, it could be deleterious... read more

Noninvasive Ventilation as Acute Therapy

Personalization of Arterial Pressure in the Perioperative Period

This review aims to discuss recent findings on the relationship between intraoperative arterial hypotension and organ dysfunction in surgical patients and examines the available evidence for personalizing blood pressure (BP)... read more

Personalization of Arterial Pressure in the Perioperative Period

Bag-Mask Ventilation during Tracheal Intubation of Critically Ill Adults

Among critically ill adults undergoing tracheal intubation, patients receiving bag-mask ventilation had higher oxygen saturations and a lower incidence of severe hypoxemia than those receiving no ventilation. Among the 401... read more

Bag-Mask Ventilation during Tracheal Intubation of Critically Ill Adults

DeepSOFA: A Continuous Acuity Score for Critically Ill Patients using Clinically Interpretable Deep Learning

Traditional methods for assessing illness severity and predicting in-hospital mortality among critically ill patients require time-consuming, error-prone calculations using static variable thresholds. These methods do not... read more

DeepSOFA: A Continuous Acuity Score for Critically Ill Patients using Clinically Interpretable Deep Learning

Effect of high-flow nasal cannula oxygen therapy in adults with acute hypoxemic respiratory failure

Conflicting recommendations exist on whether high-flow nasal cannula (HFNC) oxygen therapy should be administered to adult patients in critical care with acute hypoxemic respiratory failure. We performed a meta-analysis of... read more

Effect of high-flow nasal cannula oxygen therapy in adults with acute hypoxemic respiratory failure

Teen Who Walked While On Life Support is Home from Hospital

For the past 467 days, Zei Uwadia has been hospitalized on life support -- but that hasn't kept the quiet-natured teenager from walking, eating her favorite foods or even doing planks as exercise. Now, with determination... read more

Teen Who Walked While On Life Support is Home from Hospital

Shock: Roadside to Resus

If you're involved in the care of critically unwell patients then you will frequently encounter patients who are shocked. The European Society of Intensive Care Medicine defines shock as; "Life-threatening, generalized... read more

Shock: Roadside to Resus

A Mixed Methods Exploration of ICU Nurses’ Perception of Handling Oxygen Therapy to Critically Ill Patients

Nurses handle supplementary oxygen to intensive care unit (ICU) patients as part of their daily practice. To secure patients of optimal and safe care, knowledge of nurses' perception of this practice, including influencing... read more

A Mixed Methods Exploration of ICU Nurses’ Perception of Handling Oxygen Therapy to Critically Ill Patients

Bedside Ultrasound Assessment of Lung Reaeration in Patients With Blunt Thoracic Injury Receiving High-Flow Nasal Cannula Oxygen Therapy

High-flow nasal cannula oxygen therapy may be considered as an initial respiratory therapy for trauma patients with blunt chest injury. High-flow nasal cannula therapy could improve lung aeration as noted by the transthoracic... read more

Bedside Ultrasound Assessment of Lung Reaeration in Patients With Blunt Thoracic Injury Receiving High-Flow Nasal Cannula Oxygen Therapy

Cast of the Right Bronchial Tree

A 36-year-old man was admitted to the intensive care unit with an acute exacerbation of chronic heart failure. His medical history included heart failure with an ejection fraction of 20%, bioprosthetic aortic-valve replacement... read more

Cast of the Right Bronchial Tree

Mortality and Morbidity in Acutely Ill Adults Treated with Liberal vs. Conservative Oxygen Therapy

In acutely ill adults, high-quality evidence shows that liberal oxygen therapy increases mortality without improving other patient-important outcomes. Supplemental oxygen might become unfavourable above an SpO2 range of 94-96%.... read more

Mortality and Morbidity in Acutely Ill Adults Treated with Liberal vs. Conservative Oxygen Therapy

Assessment of the adequacy of oxygen delivery

In this article, we review physiologic principles of global oxygen delivery, and discuss the bedside approach to assessing the adequacy of oxygen delivery in critically ill patients. Although there have been technological... read more

Assessment of the adequacy of oxygen delivery

Oxygen Therapy for Acutely Ill Medical Patients

It is a longstanding cultural norm to provide supplemental oxygen to sick patients regardless of their blood oxygen saturation. A recent systematic review and meta-analysis has shown that too much supplemental oxygen increases... read more

Oxygen Therapy for Acutely Ill Medical Patients

Lessons From Everest’s Sherpas Could Aid Intensive Care Treatment

A research expedition to Mount Everest has shed light on the unique physiological basis of adaptations seen in the native Sherpa people, which make them better suited to life at high altitude. This improved understanding,... read more

Lessons From Everest’s Sherpas Could Aid Intensive Care Treatment

High-Flow Nasal Cannula in Critically Ill Subjects With or at Risk for Respiratory Failure

High-flow nasal cannula (HFNC) oxygen delivery has been gaining attention as an alternative means of respiratory support for critically ill patients, with recent studies suggesting equivalent outcomes when compared with other... read more

High-Flow Nasal Cannula in Critically Ill Subjects With or at Risk for Respiratory Failure