Subanesthetic Ketamine Infusions for the Management of Pediatric Pain in Non‐critical Care Settings

Ketamine can effectively be used as part of a multimodal analgesic regimen in pediatric patients in non‐critical care settings. Our five‐year experience using low‐dose ketamine infusions highlights an acceptable side... read more

Critical Illness and Cardiac Dysfunction in Anthracycline-Exposed Pediatric Oncology Patients

Children with cancer who received anthracyclines, especially at higher doses, and who develop cardiac dysfunction are at higher risk of critical illness, have higher rates of multiple organ dysfunction and higher rates of... read more

High-flow Oxygen Therapy for Treating Bronchiolitis in Infants

Bronchiolitis is the most common reason for hospitalization in infants worldwide. Current recommendations by the American Academy of Pediatrics are for supportive care including maintenance of hydration and oxygen support... read more

Transcutaneous CO2 vs. End-tidal CO2 in Neonates and Infants Undergoing Surgery

EtCO2 underestimates PvCO2 values in neonates and infants under general anesthesia. TcPCO2 closely approximates venous blood gas values, in both the NICU and non-NICU samples. We, therefore, conclude that tcPCO2 is a more... read more

Effect of Single-Dose Dexmedetomidine on Intraoperative Hemodynamics and Postoperative Recovery during Pediatric Adenotonsillectomy

Premedication of dexmedetomidine at the dose of 1 μg/kg in children undergoing adenotonsillectomy resulted in favorable effect on intraoperative hemodynamics, significant decrease in postoperative EA without causing any... read more

Pain in the PICU: How and What Are We Doing?

Pain management in critically ill children is complex. Epidemiological research is needed to identify how often patients in pediatric intensive care units (PICU) experience pain and the practices being used to lessen pain. Critically... read more

Developmentally Appropriate Coping in the ICU

In this video, Child Life Specialist at Boston Children's Hospital, Kate Huyler, outlines the role of a child life specialist, reviews coping strategies for patients in the ICU, including the use of playtime and behavioral... read more

An Innovative Virtual Reality Experience in the PICU

Virtual reality is an innovative, easily administered, and enjoyable tool that subjectively calms PICU patients in an otherwise chaotic environment. 100% of participants enjoyed using virtual reality, and 84% reported preference... read more

Early Protocolized Versus Usual Care Rehabilitation for Pediatric Neurocritical Care Patients

A protocol for early personalized rehabilitation by physical therapy, occupational therapy, and speech and language therapy in pediatric neurocritical care patients could be safely implemented and led to more ICU-based treatment... read more

Midazolam Dose Optimization in Critically Ill Pediatric Patients with ARF

This work leveraged available knowledge on non-heritable and heritable factors affecting midazolam pharmacokinetic in pediatric subjects with primary respiratory failure requiring mechanical ventilation, providing the basis... read more

Pediatric Hypertension and Hypertensive Emergencies: Recognition and Management in the Emergency Department

Pediatric hypertension generally presents to the ED in 2 forms: (1) the otherwise asymptomatic child with elevated blood pressure, and (2) the child with a true hypertensive emergency. This issue provides recommendations... read more

Acute Kidney Injury, Fluid Overload, and Outcomes in Children Supported With ECMO for a Respiratory Indication

This study seeks to evaluate the association between acute kidney injury (AKI), fluid overload (FO), and mortality in children supported with extracorporeal membrane oxygenation (ECMO) for refractory respiratory failure.... read more

Textbook of Critical Care

Comprehensive, concise, and readable, Textbook of Critical Care, 7th Edition, brings you fully up to date with the effective management of critically ill patients, providing the evidence-based guidance you need to overcome... read more

Textbook of Critical Care

Teaching the Principles of Pediatric Critical Care to Non-Intensivists in Resource Limited Settings

It is a dismal reality of global health that the vast majority of critically ill or injured children are found in regions of the world least equipped to care for them. Most of these severely ill or injured children are cared... read more

Oliguria and AKI in Critically Ill Children

Nearly one in five critically ill children with acute kidney injury (AKI) do not experience increase in serum creatinine. These acute kidney injury events, which are only identified by urine output criteria, are associated... read more

A Prospective Investigation of Interleukin-8 Levels in Pediatric ARF and ARDS

The association of plasma interleukin-8 (IL-8), or IL-8 genetic variants, with pediatric acute respiratory distress syndrome (PARDS) in children with acute respiratory failure (ARF) at risk for PARDS has not been examined.... read more

Neurally adjusted ventilatory assist decreases work of breathing during non-invasive ventilation in infants with severe bronchiolitis

In this physiological study, we report an improvement of respiratory unloading by adding a second level of pressure with NAVA in infants with severe bronchiolitis. WOB decreased immediately after switching to NAVA, as reported... read more

The Effects of Family Functioning on the Development of Posttraumatic Stress in Children and Their Parents Following Admission to the PICU

Both children and parents have alarmingly high rates of acute stress and posttraumatic stress following the child's PICU admission. Although family function did not emerge as a predictor in this study, further understanding... read more

Neutrophil Extracellular Traps (NETs) Exacerbate Severity of Infant Sepsis

Neutrophil extracellular traps (NETs) are innate defense mechanisms that are also implicated in the pathogenesis of organ dysfunction. However, the role of NETs in pediatric sepsis is unknown. This study reveals a hitherto... read more

Tracheal Intubation Practice and Safety Across International PICUs

There were both similarities and differences in tracheal intubation practice and outcomes across international PICUs. Fewer adverse tracheal intubation–associated events were reported from International versus North American... read more

Ethical Dilemmas in Pediatrics

Children in precarious health present particular problems for healthcare professionals because of their intimate relation to their family, and because of the family's need to provide major long-term source of support and... read more

Ethical Dilemmas in Pediatrics

Expanding the Differential for Hypotension in the Pediatric Patient

As many ED practitioners are aware, food allergies are common in the first 2 years of life, with a prevalence cited between 1-10% of the population. Most food allergies are IgE-mediated hypersensitivity reactions. Food protein-induced... read more