Haloperidol for the Management of Delirium in Adult ICU Patients

Among critically ill patients, haloperidol administration compared with placebo does not significantly affect short-term mortality, incidence of delirium, ICU length of stay, or delirium or coma-free days. Additionally, there... read more

Haloperidol for the Management of Delirium in Adult ICU Patients

Effect of Levocarnitine vs Placebo as an Adjunctive Treatment for Septic Shock

In this dose-finding, phase 2 adaptive randomized trial, patients with septic shock and moderate organ dysfunction were treated early in the course of illness with low (6 g), medium (12 g), or high (18 g) doses of levocarnitine... read more

Effect of Levocarnitine vs Placebo as an Adjunctive Treatment for Septic Shock

Remodeling ICU Care

A new study finding that two antipsychotics were no more effective than placebo for delirium in critical illness spurs discussion about alternative methods for managing that care. Neither haloperidol nor ziprasidone — both... read more

Remodeling ICU Care

Caffeine Accelerates Emergence from Isoflurane Anesthesia in Humans

Intravenous caffeine is able to accelerate emergence from isoflurane anesthesia in healthy males without any apparent adverse effects. All randomized participants were included in the analysis. The mean time to emergence... read more

Caffeine Accelerates Emergence from Isoflurane Anesthesia in Humans

Positive Topline Results for Novel Alzheimer’s Drug

A novel drug is showing promise for helping improve cognition in patients with mild to moderate Alzheimer's disease (AD), according to new topline results. A phase 3 trial of more than 800 patients showed that those who were... read more

Positive Topline Results for Novel Alzheimer’s Drug

Effect of Bronchodilation, Exercise Training, and Behavior Modification on Symptoms and Physical Activity in COPD

Tiotropium/olodaterol, with or without ExT, improved EET in patients with Chronic Obstructive Pulmonary Disease (COPD) taking part in an SMBM program. Combination bronchodilation, with or without ExT, did not provide additional... read more

Effect of Bronchodilation, Exercise Training, and Behavior Modification on Symptoms and Physical Activity in COPD

Hydrocortisone plus Fludrocortisone for Adults with Septic Shock

The use of steroids in critically ill patients continues to be controversial. Whilst there are signals for improved cardiovascular parameters, this did not translate to clear mortality benefits. The most recent of these trials... read more

Hydrocortisone plus Fludrocortisone for Adults with Septic Shock

Low-dose vs. High-dose Magnesium in Rapid Afib

Magnesium sulfate has been used as an adjunct medication for the treatment of atrial fibrillation (AF) due to its ability to lessen sinus node depolarization via calcium antagonism. Prior studies investigating magnesium in... read more

Low-dose vs. High-dose Magnesium in Rapid Afib

Adjunctive Glucocorticoid Therapy in Patients with Septic Shock

Among patients with septic shock undergoing mechanical ventilation, a continuous infusion of hydrocortisone did not result in lower 90-day mortality than placebo. We randomly assigned patients with septic shock who were undergoing... read more

Adjunctive Glucocorticoid Therapy in Patients with Septic Shock

Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults

Between Feb 6, 2014, and June 26, 2016, 1360 patients were assessed, and 672 were randomly assigned, with 222 in the placebo group, 227 in the 0·5 mg/kg ketamine group, and 223 in the 1·0 mg/kg ketamine group. There was... read more

Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults

Placebo Plus Usual Treatment Achieves Clinically Significant Back Pain Relief

A placebo of a pill added to treatment as usual for chronic low back pain resulted in clinically significant improvements in patients who were informed about the placebo beforehand, according to a new study from Portugal. All... read more

Placebo Plus Usual Treatment Achieves Clinically Significant Back Pain Relief

Vitamin D and outcomes in adult critically ill patients

In critically ill patients, vitamin D administration might be associated with a reduction in mortality without significant adverse events. A large multicenter randomized trial should conclusively confirm these findings. Seven... read more

Efficacy of Oral Risperidone, Haloperidol, or Placebo for Symptoms of Delirium Among Patients in Palliative Care

In patients receiving palliative care, individualized management of delirium precipitants and supportive strategies result in lower scores and shorter duration of target distressing delirium symptoms than when risperidone... read more

Efficacy of Oral Risperidone, Haloperidol, or Placebo for Symptoms of Delirium Among Patients in Palliative Care

No difference between placebo, amitriptyline and topiramate in reducing pediatric migraine

In this study, no significant intergroup differences between amitriptyline, topiramate and placebo for reduction in total number of headache days was observed. Amitriptyline and topiramate were associated with significantly... read more

No difference between placebo, amitriptyline and topiramate in reducing pediatric migraine

Neuroprotective Effects of the Glucagon-Like Peptide-1 Analog Exenatide After Out-of-Hospital Cardiac Arrest

Acute administration of exenatide to comatose patients in the ICU after OHCA is feasible and safe. Exenatide did not reduce neuron-specific enolase levels and did not significantly improve a composite end point of death and... read more

Neuroprotective Effects of the Glucagon-Like Peptide-1 Analog Exenatide After Out-of-Hospital Cardiac Arrest

Short-term Effects of High-Dose Caffeine on Cardiac Arrhythmias in Patients With Heart Failure

This randomized clinical trial evaluates the short-term effects of high-dose caffeine consumption vs placebo in patients with heart failure at increased risk for arrhythmic events. After 500 mg of caffeine administered over... read more

Short-term Effects of High-Dose Caffeine on Cardiac Arrhythmias in Patients With Heart Failure

Examining Pantoprazole or Placebo for Stress Ulcer Prophylaxis

Pantoprazole is frequently administered to critically ill patients for prophylaxis against gastrointestinal bleeding. However, comparison to placebo has been inadequately evaluated, and pantoprazole has the potential to cause... read more

Examining Pantoprazole or Placebo for Stress Ulcer Prophylaxis

Signs of Cardioprotection Seen in Acute STEMI Patients Receiving IV Beta-blocker Post-PCI

Patients with STEMI who receive IV infusion of the beta-blocker esmolol within 60 minutes after successful PCI tend to release smaller amounts of cardiac biomarkers than those given placebo, researchers of a single-center,... read more

Signs of Cardioprotection Seen in Acute STEMI Patients Receiving IV Beta-blocker Post-PCI