Tag: placebo
Caffeine Accelerates Emergence from Isoflurane Anesthesia in Humans
Intravenous caffeine is able to accelerate emergence from isoflurane anesthesia in healthy males without any apparent adverse effects. All randomized participants were included in the analysis. The mean time to emergence... read more
Positive Topline Results for Novel Alzheimer’s Drug
A novel drug is showing promise for helping improve cognition in patients with mild to moderate Alzheimer's disease (AD), according to new topline results. A phase 3 trial of more than 800 patients showed that those who were... read more
Effect of Bronchodilation, Exercise Training, and Behavior Modification on Symptoms and Physical Activity in COPD
Tiotropium/olodaterol, with or without ExT, improved EET in patients with Chronic Obstructive Pulmonary Disease (COPD) taking part in an SMBM program. Combination bronchodilation, with or without ExT, did not provide additional... read more
Hydrocortisone plus Fludrocortisone for Adults with Septic Shock
The use of steroids in critically ill patients continues to be controversial. Whilst there are signals for improved cardiovascular parameters, this did not translate to clear mortality benefits. The most recent of these trials... read more
Low-dose vs. High-dose Magnesium in Rapid Afib
Magnesium sulfate has been used as an adjunct medication for the treatment of atrial fibrillation (AF) due to its ability to lessen sinus node depolarization via calcium antagonism. Prior studies investigating magnesium in... read more
Adjunctive Glucocorticoid Therapy in Patients with Septic Shock
Among patients with septic shock undergoing mechanical ventilation, a continuous infusion of hydrocortisone did not result in lower 90-day mortality than placebo. We randomly assigned patients with septic shock who were undergoing... read more
Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults
Between Feb 6, 2014, and June 26, 2016, 1360 patients were assessed, and 672 were randomly assigned, with 222 in the placebo group, 227 in the 0·5 mg/kg ketamine group, and 223 in the 1·0 mg/kg ketamine group. There was... read more
Placebo Plus Usual Treatment Achieves Clinically Significant Back Pain Relief
A placebo of a pill added to treatment as usual for chronic low back pain resulted in clinically significant improvements in patients who were informed about the placebo beforehand, according to a new study from Portugal. All... read more
Vitamin D and outcomes in adult critically ill patients
In critically ill patients, vitamin D administration might be associated with a reduction in mortality without significant adverse events. A large multicenter randomized trial should conclusively confirm these findings. Seven... read more
Efficacy of Oral Risperidone, Haloperidol, or Placebo for Symptoms of Delirium Among Patients in Palliative Care
In patients receiving palliative care, individualized management of delirium precipitants and supportive strategies result in lower scores and shorter duration of target distressing delirium symptoms than when risperidone... read more
No difference between placebo, amitriptyline and topiramate in reducing pediatric migraine
In this study, no significant intergroup differences between amitriptyline, topiramate and placebo for reduction in total number of headache days was observed. Amitriptyline and topiramate were associated with significantly... read more
Neuroprotective Effects of the Glucagon-Like Peptide-1 Analog Exenatide After Out-of-Hospital Cardiac Arrest
Acute administration of exenatide to comatose patients in the ICU after OHCA is feasible and safe. Exenatide did not reduce neuron-specific enolase levels and did not significantly improve a composite end point of death and... read more
Short-term Effects of High-Dose Caffeine on Cardiac Arrhythmias in Patients With Heart Failure
This randomized clinical trial evaluates the short-term effects of high-dose caffeine consumption vs placebo in patients with heart failure at increased risk for arrhythmic events. After 500 mg of caffeine administered over... read more
Examining Pantoprazole or Placebo for Stress Ulcer Prophylaxis
Pantoprazole is frequently administered to critically ill patients for prophylaxis against gastrointestinal bleeding. However, comparison to placebo has been inadequately evaluated, and pantoprazole has the potential to cause... read more
Signs of Cardioprotection Seen in Acute STEMI Patients Receiving IV Beta-blocker Post-PCI
Patients with STEMI who receive IV infusion of the beta-blocker esmolol within 60 minutes after successful PCI tend to release smaller amounts of cardiac biomarkers than those given placebo, researchers of a single-center,... read more
