Tag: pneumonia
Distinguishing Pneumonia From Pneumonitis to Safely Discontinue Antibiotics
Consequences of pulmonary aspiration can be biphasic with dissimilar sequelae. An early phase, coined pneumonitis, involves an inflammatory reaction to gastrointestinal contents with a pH typically less than 2.4 resulting... read more
Immunocompromised Patients with ARDS
Immunosuppression is frequent in patients with acute respiratory distress syndrome (ARDS), and infections are the main risk factors for ARDS in these immunocompromised patients. Their management differs from that of immunocompetent... read more
Automated System Detects Risk of VAP
Approximately 50 percent of all patients receiving mechanical ventilator support develop ventilator-associated pneumonia (VAP). Researchers at Massachusetts General Hospital (MGH) have developed an automated system for identifying... read more
A 10-year review of total hospital onset ICU bloodstream infections at an Academic Medical Center
Across all ICUs, the rates of primary BSIs progressively fell from 2.11/1000 patient days in FY05 to 0.32/1000 patient days in FY14; an 85.0% decrease (P<0.0001). Secondary BSIs also progressively decreased from 3.56/1000... read more
Metabolic Profiles in Community-Acquired Pneumonia
This study demonstrates that serum metabolomics approaches based on the LC-MS/MS platform can be applied as a tool to reveal metabolic changes during CAP and establish a metabolite signature related to disease severity. The... read more
Mechanical Ventilation: Physiological and Clinical Applications
Known for its simple explanations and in-depth coverage of patient-ventilator management, this evidence-based text walks readers through the most fundamental and advanced concepts surrounding mechanical ventilation and guides... read more
Empiric Antibiotics Tend To Be Prolonged in ICU
Using antibiotics in critically ill patients is very much walking a tightrope. No one wants to miss an infection in a patient who could go downhill quickly, but no one wants to overuse these precious drugs, either.... read more
Risk Factors for HAI After Pediatric Cardiac Surgery
Mechanical ventilation greater than or equal to 3 days, dopamine use, genetic abnormality, and delayed sternal closure were associated with healthcare-associated infections after pediatric cardiac surgery. Since the use of... read more
Antibiotic Therapy in Comatose Mechanically Ventilated Patients Following Aspiration
Dr. Fraser, MD, speaks with Jean Baptiste Lascarrou, MD, about the article, "Antibiotic Therapy in Comatose Mechanically Ventilated Patients Following Aspiration: Differentiating Pneumonia from Pneumonitis," published in... read more
Tracheotomy in the ICU: Guidelines from a French Expert Panel
Tracheotomy is widely used in intensive care units (ICUs), albeit with great disparities between medical teams in terms of frequency and modality. Indications and techniques are, however, associated with variable levels of... read more
Temporal Trends in Incidence, Sepsis-Related Mortality, and Hospital-Based Acute Care After Sepsis
Owing to increasing incidence and declining mortality, the number of sepsis survivors at risk for hospital readmission rose significantly between 2010 and 2015. The 30-day hospital readmission rates for sepsis declined modestly... read more
A Doctor Without Health Insurance? What Could Go Wrong?
It's probably nothing. That's what I said to myself not long ago when I started feeling lousy. I should know, since I'm a physician. But I learned the hard way that those "nothings" can get serious fast - and without health... read more
Noninvasive Ventilation in Patients With Do-Not-Intubate and Comfort-Measures-Only Orders
A large proportion of patients with do-not-intubate orders who received noninvasive ventilation survived to hospital discharge and at 1 year, with limited data showing no decrease in quality of life in survivors. Provision... read more
Incidence of NV-HAP in the United States
Because nonventilator hospital-acquired pneumonia (NV-HAP) is understudied, our purpose was to determine the incidence, overall burden, and level of documented pneumonia preventive interventions of NV-HAP in 24 U.S. hospitals.... read more
Trends of Incidence and Risk Factors of VAP in Elderly Patients Admitted to French ICUs
This study assesses trends and risk factors of ventilator-associated pneumonia (VAP) according to age, particularly in the elderly admitted to French ICUs between 2007 and 2014. Ventilator-associated pneumonia incidence is... read more
REPROVE: Ceftazidime-avibactam Noninferior to Meropenem for Nosocomial Pneumonia
Ceftazidime-avibactam was noninferior to meropenem for nosocomial pneumonia including ventilator-associated pneumonia (VAP) from gram-negative organisms, results from the REPROVE trial demonstrated. Nosocomial or hospital-acquired... read more
Long-Term Cognitive Impairment after Hospitalization for Community-Acquired Pneumonia
Recent studies suggest older patients hospitalized for community-acquired pneumonia are at risk for new-onset cognitive impairment. The characteristics of long-term cognitive impairment after pneumonia, however, have not... read more
FDA Approves Treatment of Patients with Hospital-Acquired Bacterial Pneumonia and Ventilator-Associated Bacterial Pneumonia
FDA has approved Allergan's supplemental New Drug Application (sNDA) to expand the approved use of AVYCAZ® (ceftazidime and avibactam) to include the treatment of hospital-acquired bacterial pneumonia and ventilator-associated... read more
Radiologist-Level Pneumonia Detection on Chest X-Rays with Deep Learning
We develop an algorithm that can detect pneumonia from chest X-rays at a level exceeding practicing radiologists. Our algorithm, CheXNet, is a 121-layer convolutional neural network trained on ChestX-ray14, currently the... read more
Stress Ulcer Prophylaxis in ICU Patients Receiving Enteral Nutrition
Our results suggested that in patients receiving enteral feeding, pharmacologic SUP is not beneficial and combined interventions may even increase the risk of nosocomial pneumonia. We searched PubMed, Embase, and the Cochrane... read more
