The Lactate Dilemma

After a long and exhausting discussion with an inferior human being, a cardiologist, which happens to be an old friend, I decided to write some thoughts about lactate. So, I'll do like I do in my lectures, which is state... read more

The Lactate Dilemma

Stress Ulcer Prophylaxis in the ICU (SUP-ICU)

Stress ulcer prophylaxis (SUP) is standard of care in the intensive care unit (ICU), however the quantity and quality of evidence is low and potential harm has been reported. The aim of the SUP-ICU trial is to asses the overall... read more

Stress Ulcer Prophylaxis in the ICU (SUP-ICU)

Role of Preventability in Redefining Failure to Rescue Among Major Trauma Patients

Failure to rescue (FTR) is defined as death after a major complication and has been adopted as a measure of quality in surgical patients. Current definitions of FTR are limited because they do not account for the influence... read more

Role of Preventability in Redefining Failure to Rescue Among Major Trauma Patients

Antibiotic Therapy in Comatose Mechanically Ventilated Patients Following Aspiration

Among comatose patients receiving mechanical ventilation, those without clinical, laboratory, or radiologic evidence of bacterial aspiration pneumonia did not require antibiotics. In those with suspected bacterial aspiration... read more

Antibiotic Therapy in Comatose Mechanically Ventilated Patients Following Aspiration

Aspirin therapy in patients with ARDS is associated with reduced ICU mortality

Acute respiratory distress syndrome (ARDS) is a common clinical syndrome with high mortality and long-term morbidity. To date there is no effective pharmacological therapy. Aspirin therapy has recently been shown to reduce... read more

Aspirin therapy in patients with ARDS is associated with reduced ICU mortality

Rescue Strategy for Treating Severe Carbapenemase-Producing Klebsiella Pneumoniae Infections

Recent reports have suggested the efficacy of a double carbapenem (DC) combination, including ertapenem, for the treatment of carbapenem-resistant Klebsiella pneumoniae (CR-Kp) infections. We aimed to evaluate the clinical... read more

Rescue Strategy for Treating Severe Carbapenemase-Producing Klebsiella Pneumoniae Infections

Withholding Pantoprazole for Stress Ulcer Prophylaxis in Critically Ill Patients

A decreased frequency of upper gastrointestinal bleeding and a possible association of proton pump inhibitor use with Clostridium difficile and ventilator-associated pneumonia have raised concerns recently. The Reevaluating... read more

Cluster-Randomized, Crossover Trial of Head Positioning in Acute Stroke

The role of supine positioning after acute stroke in improving cerebral blood flow and the countervailing risk of aspiration pneumonia have led to variation in head positioning in clinical practice. Disability outcomes after... read more

Cluster-Randomized, Crossover Trial of Head Positioning in Acute Stroke

COPD can increase risk of developing sepsis

People with COPD have a higher than average risk of developing lung infections, such as pneumonia, which then puts them at higher risk for developing sepsis. Sepsis and septic shock can result from an infection anywhere in... read more

COPD can increase risk of developing sepsis

Humidification During Mechanical Ventilation: A Systematic Review

Mechanical ventilation (MV) suppresses the mechanisms that heat and moisturise inhaled air; hence, humidification is mandatory during MV. However, a systematic review published in the journal Critical Care finds no clear... read more

Humidification During Mechanical Ventilation: A Systematic Review

The impact of oral care on oral health status and prevention of VAP in critically ill patients

Ventilator-associated pneumonia (VAP) is one of the most common nosocomial infections which increase mortality rate and length stay of hospitalization. Oral care would not only improve patient’s oral health and well-being,... read more

The impact of oral care on oral health status and prevention of VAP in critically ill patients

Plasma metabolomics for the diagnosis and prognosis of H1N1 influenza pneumonia

Metabolomics is a tool that has been used for the diagnosis and prognosis of specific diseases. The purpose of this study was to examine if metabolomics could be used as a potential diagnostic and prognostic tool for H1N1... read more

Plasma metabolomics for the diagnosis and prognosis of H1N1 influenza pneumonia

Early Palliative Care in Advanced Illness

As the on-call pulmonary critical care fellow, I listened to a family member plead with me to "do right by Mama." The emergency department team consulted me for possible intensive care unit (ICU) admission on a... read more

Early Palliative Care in Advanced Illness

Value-Based Reforms and the Hospital Readmission Reduction Program

In this longitudinal study of 2837 US hospitals between 2008 and 2015, we found that participation in 1 or more Medicare value-based reforms - including the Meaningful Use of Electronic Health Records program, the Accountable... read more

Value-Based Reforms and the Hospital Readmission Reduction Program

A Call for Fresh Airway Management Standards

Anesthesiology News recently reported on a study that promoted the LMA in prone position to "avoid intubation, reduce use of relaxants and minimize airway trauma." This study reflects increasing confusion in a complex... read more

A Call for Fresh Airway Management Standards

Perceived safety and value of inpatient "very important person" services

Providing care to "very important person" (VIP) patients can pose unique moral and value-based challenges for providers. No studies have examined VIP services in the inpatient setting. Through a multi-institutional... read more

Perceived safety and value of inpatient "very important person" services

Ultra-Short-Course Antibiotics for Patients With Suspected Ventilator-Associated Pneumonia but Minimal and Stable Ventilator Settings

Many patients started on antibiotics for possible ventilator-associated pneumonia (VAP) do not have pneumonia. Patients with minimal and stable ventilator settings may be suitable candidates for early antibiotic discontinuation.... read more

Ultra-Short-Course Antibiotics for Patients With Suspected Ventilator-Associated Pneumonia but Minimal and Stable Ventilator Settings

World's most threatening superbugs ranked in new list

The World Health Organization has drawn up a list of the drug-resistant bacteria that pose the biggest threat to human health. Top of the list are gram-negative bugs, such as E. coli, which can cause lethal bloodstream infections... read more

World's most threatening superbugs ranked in new list

Sepsis Readmissions Compared With Other Medical Conditions

This study uses data from a US readmissions database to assess whether sepsis hospitalizations account for a higher proportion of unplanned 30-day readmissions than hospitalizations for acute myocardial infarction, heart... read more

Sepsis Readmissions Compared With Other Medical Conditions

New Infection Data and Sepsis-Guideline Critique at SCCM

The potential of probiotics to reduce nosocomial infections and ventilator-associated pneumonia in the critically ill and the latest data on readmissions will be among the major research advances presented here at the Society... read more

New Infection Data and Sepsis-Guideline Critique at SCCM