The ADRENAL Trial: Steroids in Septic Shock

Randomized clinical trials evaluating the efficacy of adjunctive corticosteroids in septic shock have shown conflicting evidence of clinical relevance. Two trials in particular looked at lower dose hydrocortisone (200mg/day)... read more

The ADRENAL Trial: Steroids in Septic Shock

Acute Kidney Injury in Sepsis

Acute kidney injury (AKI) and sepsis carry consensus definitions. The simultaneous presence of both identifies septic AKI. Septic AKI is the most common AKI syndrome in ICU and accounts for approximately half of all such... read more

Acute Kidney Injury in Sepsis

Initial Crystalloid Resuscitation in Sepsis and Septic Shock

Ludwig Lin, MD, speaks with Daniel E. Leisman, BS, about the article, "Patterns and Outcomes Associated With Timeliness of Initial Crystalloid Resuscitation in a Prospective Sepsis and Septic Shock Cohort," published in Critical... read more

The EM Educator Series: Sepsis in the ED

These posts provide brief mini-cases followed by key questions to consider while working. The featured questions provide important learning points for those working with you, as well as vital items to consider in the evaluation... read more

The EM Educator Series: Sepsis in the ED

Patient Experiences of Trauma Resuscitation

In this qualitative study that included semistructured interviews and video observations of trauma resuscitation, patients drew satisfaction from trauma team members' demeanor, expertise, and efficiency and valued clear... read more

Patient Experiences of Trauma Resuscitation

Guidelines for Point-of-Care Use of Transesophageal Echocardiography in Cardiac Arrest Resuscitation

In patients with cardiac arrest, transesophageal echocardiography (TEE) may provide greater benefits than transthoracic echocardiography (TTE) for imaging, diagnosis, and prognosis, according to a review paper published in... read more

Guidelines for Point-of-Care Use of Transesophageal Echocardiography in Cardiac Arrest Resuscitation

Post Resuscitation Management of Cardiac Arrest Patients in the Critical Care Environment

There is a clear relationship between evidence-based post resuscitation care and survival and functional status at hospital discharge. The Australian Resuscitation Council (ARC) recommends protocol driven care to enhance... read more

Post Resuscitation Management of Cardiac Arrest Patients in the Critical Care Environment

Intra-Abdominal Hypertension and Abdominal Compartment Syndrome

Intra-abdominal hypertension (IAH) and abdominal compartment syndrome are increasingly recognized in both medical and surgical critically ill patients and are predictive of death and the development of acute kidney injury.... read more

Intra-Abdominal Hypertension and Abdominal Compartment Syndrome

Tissue Edema, Fluid Balance, and Patient Outcomes in Severe Sepsis

Severe sepsis and septic shock remain among the deadliest diseases managed in the intensive care unit. Fluid resuscitation has been a mainstay of early treatment, but the deleterious effects of excessive fluid administration... read more

Tissue Edema, Fluid Balance, and Patient Outcomes in Severe Sepsis

Causes for Pauses During Simulated Pediatric Cardiac Arrest

Pauses in cardiopulmonary resuscitation occurred frequently during simulated pediatric cardiac arrest, with variable duration and underlying causes. A large percentage of pauses were greater than 10 seconds and occurred more... read more

Causes for Pauses During Simulated Pediatric Cardiac Arrest

Ventilation Rate During Adult CPR with Tracheal Tube

The optimal ventilation rate during cardiopulmonary resuscitation (CPR) with a tracheal tube is unknown. A new systematic review finds that a ventilation rate recommendation of 10 min-1 during adult CPR with a secure airway... read more

Ventilation Rate During Adult CPR with Tracheal Tube

Reducing Brain Injury After Cardiac Arrest

Therapeutic hypothermia (TH) (32-34°C for 24 hours) should be mandatory practice for patients who are comatose after being resuscitated from out-of-hospital cardiac arrest, if the initial cardiac rhythm is either pulseless... read more

Reducing Brain Injury After Cardiac Arrest

Recent Developments in Management of Critical Burn Injuries

Recent reports emphasize the dangers of over resuscitation in the setting of burn injury. No new medical therapy for inhalation injury has been generally adopted, but new standards for description of burn-related infections... read more

Recent Developments in Management of Critical Burn Injuries

Resuscitating Sepsis – How I do it after Albios

Watch "Resuscitating Sepsis - How I do it after Albios" by Luciano Gattinoni.... read more

Resuscitating Sepsis – How I do it after Albios

The Complexities of Intravenous Fluid Research: Questions of Scale, Volume, and Accumulation

Despite near ubiquity, information regarding fluids consumption at a health care systems level, and patient exposure at an individual level, is surprisingly limited in the medical literature. The epidemiology of the foundational... read more

The Complexities of Intravenous Fluid Research: Questions of Scale, Volume, and Accumulation

Low-volume Resuscitation with Normal Saline is Associated with Microvascular Endothelial Dysfunction After Hemorrhage

Low-volume resuscitation with normal saline is associated with microvascular endothelial dysfunction after hemorrhage in rats, compared to colloids and balanced crystalloids. Resuscitation with NS failed to inhibit syndecan-1... read more

Low-volume Resuscitation with Normal Saline is Associated with Microvascular Endothelial Dysfunction After Hemorrhage

Detection of Pulmonary Embolism During Cardiac Arrest

The aim of this study was to test the hypothesis that the right ventricle is more dilated during resuscitation from cardiac arrest caused by pulmonary embolism, compared with hypoxia and primary arrhythmia. The right ventricle... read more

Detection of Pulmonary Embolism During Cardiac Arrest

Sepsis E-alert System with Response Team Improves Outcomes

According to a new study, the use of a multifaceted intervention including an electronic sepsis alert (e-alert) system with sepsis response team was associated with improvement in care processes of sepsis and septic shock... read more

Sepsis E-alert System with Response Team Improves Outcomes

Defibrillator-carrying drones could save lives, research suggests

Drones are already employed for anything from military to recreational use, from oil exploration to film-making, but they could also help save the lives of people who have suffered a cardiac arrest, research suggests. A... read more

Defibrillator-carrying drones could save lives, research suggests

Malbrain Fluid Overload

Fluid overload is associated with increased morbidity and mortality. In this presentations an overview is given of the different definitions followed by a step-by-step description of the deleterious effects of fluid overload... read more

Malbrain Fluid Overload

Volume responsiveness and volume tolerance: a conceptual diagram

So I know I've be-laboured the point about the difference between volume responsiveness (i.e. will there be significant increase in cardiac output with volume infusion) and volume tolerance (is the volume I am considering... read more

Volume responsiveness and volume tolerance: a conceptual diagram

Improving CPR Performance

Cardiac arrest continues to represent a public health burden with most patients having dismal outcomes. Cardiopulmonary resuscitation (CPR) is a complex set of interventions requiring leadership, coordination, and best practices.... read more

Improving CPR Performance