Tag: sepsis
Sepsis and Therapeutic Interventions
The global burden of sepsis is substantial. Therefore, in a retrospective before-after clinical study, Marik et al compared the outcome and clinical course of consecutive septic patients treated with intravenous vitamin C,... read more
Why a stay in the ICU can leave patients worse off
Almost 6 million patients land in an intensive care unit every year, and for many, it marks a turning point in their lives. A substantial number of patients leave the ICU with newly acquired problems, from dementia to nerve... read more
COPD can increase risk of developing sepsis
People with COPD have a higher than average risk of developing lung infections, such as pneumonia, which then puts them at higher risk for developing sepsis. Sepsis and septic shock can result from an infection anywhere in... read more
Sepsis E-alert System with Response Team Improves Outcomes
According to a new study, the use of a multifaceted intervention including an electronic sepsis alert (e-alert) system with sepsis response team was associated with improvement in care processes of sepsis and septic shock... read more
Potential survival benefit of polymyxin B hemoperfusion in patients with septic shock
The purpose of this study was to investigate whether polymyxin B hemoperfusion (PMX-HP) improves the survival of patients with septic shock. Our results strongly suggest that PMX-HP reduces all-cause hospital mortality and... read more
Management of Septic Shock
The results of the PRISM trials confirm that early intervention strategies, including early detection of sepsis, risk stratification, early administration of antibiotics, and appropriate fluid resuscitation, improve the outcomes... read more
Malnutrition, Critical Illness Survivors, and Postdischarge Outcomes
The exposure of interest was malnutrition determined at intensive care unit (ICU) admission by a registered dietitian using clinical judgment and on data related to unintentional weight loss, inadequate nutrient intake, and... read more
ER Overcrowding Delays Sepsis Treatment
Prompt antibiotic initiation is associated with improved mortality in sepsis and septic shock. However, new research shows that patients with sepsis, a life-threatening complication of an infection, had delays approaching... read more
Personalised Medicine in Intensive Care
The specialty of intensive care medicine grew out of the realisation that critically ill patients needed more attention and specialised treatment than could be provided on a general ward, and that many of these patients had... read more
WHA Adopts Resolution on Sepsis
World Health Assembly and the World Health Organization made sepsis a global health priority, by adopting a resolution to improve, prevent, diagnose, and manage sepsis. This marks a quantum leap in the global fight against... read more
Addressing Sepsis – Video Recap of the WHA Side Event on Sepsis
On the occasion of the World Health Assembly passing a resolution on sepsis, the Global Sepsis Alliance, IAPO, and the German Federal Ministry of Health have hosted the "WHA Side Event on Sepsis" in Geneva on May... read more
Generalizable Biomarkers in Critical Care
The sequencing of the human genome and the subsequent availability of inexpensive, robust methods for "omics" profiling (e.g., genome-wide association studies, gene expression microarrays, and metabolomics) have... read more
Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock
The American College of Critical Care Medicine provided 2002 and 2007 guidelines for hemodynamic support of newborn and pediatric septic shock. Provide the 2014 update of the 2007 American College of Critical Care Medicine... read more
Diagnostic work-up and specific causes of acute kidney injury
Acute kidney injury (AKI) is common in critically ill patients and associated with grim short- and long-term outcome. Although in the vast majority of cases AKI is multifactorial, with sepsis, shock and nephrotoxicity accounting... read more
Albumin Administration in Sepsis: The Case for and Against
Serum albumin is an essential plasma protein, with a variety of homeostatic and predictive roles in health and disease. Hypoalbuminaemia is common in critical illness. Human albumin solution has been administered clinically... read more
Implications of Prevalent Noncardiac Disease in the Cardiac ICU
Half of >1000 patients of admitted to the cardiac intensive care unit (ICU) at a major tertiary-care center over about 1 year also had acute respiratory failure, acute kidney injury, or sepsis. Those with lung or kidney... read more
Serial Procalcitonin Predicts Mortality in Severe Sepsis Patients
Objectives: To prospectively validate that the inability to decrease procalcitonin levels by more than 80% between baseline and day 4 is associated with increased 28-day all-cause mortality in a large sepsis patient population... read more
Clinical Sensors lands $1.5 million in NIH grants for sepsis work
Clinical Sensors, a startup based in Research Triangle Park, North Carolina, has been awarded two Small Business Research Grants from the National Institutes of Health. Together, the grants total $1.5 million and are earmarked... read more
