Pediatric screening for family hypercholesterolemia is feasible and efficacious

Pediatric screening for family hypercholesterolemia is feasible and efficacious

Presence of a familial hypercholesterolemia mutation without elevated total cholesterol levels is insufficient to make diagnosis of familial hypercholesterolemia.... read more

Treated bacteremia that clears, then recurs, termed 'skip phenomenon'

Treated bacteremia that clears, then recurs, termed 'skip phenomenon'

About 4% of S. aureus bacteremia cases may not clear completely, as judged by one negative blood culture, contrary to recent IDSA guidelines.... read more

Antibiotics Linked to Sepsis Risk

Antibiotics Linked to Sepsis Risk

Disturbing healthy bacteria during hospital admission associated with later sepsis.... read more

Spontaneous breathing trial and post-extubation work of breathing in morbidly obese critically ill patients

Spontaneous breathing trial and post-extubation work of breathing in morbidly obese critically ill patients

Predicting whether an obese critically ill patient can be successfully extubated may be specially challenging. Several weaning tests have been described but no physiological study has evaluated the weaning test that would... read more

Cefiderocol, A Novel Investigational Siderophore Cephalosporin, Demonstrated Potent Activity Against Multi-Drug Resistant Gram-Negative Pathogens

Cefiderocol, A Novel Investigational Siderophore Cephalosporin, Demonstrated Potent Activity Against Multi-Drug Resistant Gram-Negative Pathogens

Cefiderocol showed potent activity against Gram-negative pathogens, including carbapenem-resistant strains of Pseudomonas aeruginosa and Acinetobacter baumannii as well as carbapenem-resistant Enterobacteriaceae. The results... read more

Assessing Tissue Oxygenation and Microvascular Reactivity in ICU Patients

Assessing Tissue Oxygenation and Microvascular Reactivity in ICU Patients

Impaired microcirculatory perfusion and tissue oxygenation during critical illness are associated with adverse outcome.... read more

Scrubs Pick Up Bad Hospital Germs

Scrubs Pick Up Bad Hospital Germs

The scrubs of intensive care unit (ICU) nurses often pick up disease-causing germs, including those resistant to antibiotics, a new study reports. The study included 40 intensive care unit nurses.... read more

Patients benefit from tranexamic acid in surgery, withholding blood pressure meds before

Patients benefit from tranexamic acid in surgery, withholding blood pressure meds before

Four innovative studies exploring ways to reduce complications related to heart surgery or minimize patient mortality due to risks associated with low blood pressure and surgery.... read more

Inappropriate Antibiotic Selection Among US Ambulatory Care Visits

Inappropriate Antibiotic Selection Among US Ambulatory Care Visits

This study measures the frequency with which first-line antibiotics are prescribed for otitis media, sinusitis, and pharyngitis.... read more

Germ-Zappers Are Saving Lives

Germ-Zappers Are Saving Lives

Meet the world's only full-spectrum ultraviolet germ-zapping robot - the creation of Xenex Disinfection Services. The Xenex robot is now used in more than 300 hospitals in the United States.... read more

Liraglutide increases heart rate in T2DM with stable CAD

Liraglutide increases heart rate in T2DM with stable CAD

Liraglutide increases heart rate (HR) and reduces heart rate variability (HRV) in overweight patients with newly diagnosed type 2 diabetes (T2D) and stable coronary artery disease (CAD).... read more

Ultraviolet air sterilizer reduces sepsis and mortality in cardiac surgery patients

Ultraviolet air sterilizer reduces sepsis and mortality in cardiac surgery patients

An ultraviolet air steriliser reduces sepsis and mortality in cardiac surgery patients, according to this research. The investigators found that sepsis occurred in 3.4% of patients using the steriliser compared to 6.7% patients... read more

New-Onset Atrial Fibrillation Post-CABG More Common, Lasts Longer in Men Than in Women

New-Onset Atrial Fibrillation Post-CABG More Common, Lasts Longer in Men Than in Women

In the ongoing push to understand the link between CABG surgery and new-onset atrial fibrillation, a large, multicenter registry has found that women were at lower risk of developing post-CABG A-fib.... read more

Immune system of African Americans responds more strongly to bacterial infection, and it is partly genetic

Immune system of African Americans responds more strongly to bacterial infection, and it is partly genetic

A Canada-US study has demonstrated that Americans of African descent have a stronger immune response to infection compared to Americans of European descent.... read more

Landmark genetics study to improve prediction of heart disease recruits 20,000th participant

Landmark genetics study to improve prediction of heart disease recruits 20,000th participant

A team of researchers from the University of Leicester and NIHR Leicester Cardiovascular Biomedical Research Unit (LCBRU) in conjunction with colleagues from Primary Care and Leicester and Leicestershire CCGs have recruited... read more

Spread of cancer linked to cell metabolism, study shows

Spread of cancer linked to cell metabolism, study shows

Cellular metabolism in white blood cells can be manipulated to prevent the spread of cancer, VIB and KU Leuven researchers suggest in a new study.... read more

Impaired recycling of mitochondria in autism?

Impaired recycling of mitochondria in autism?

The new study shows that autophagy is defective in TSC. The scientists further showed that two existing classes of drugs counter the defect: the epilepsy drug carbamazepine, and drugs known as mTOR inhibitors.... read more