Tag: study

Clinical Characteristics of Patients With COVID-19 Receiving Emergency Medical Services

This cohort study of 124 patients with COVID-19 revealed that most patients with COVID-19 presenting to emergency medical services were older and had multiple chronic health conditions. Initial concern, symptoms, and examination... read more

Five COVID-19 Mysteries Scientists Are Still Racing to Solve

Six months and more than ten million confirmed cases later, the COVID-19 pandemic has become the worst public-health crisis in a century. More than 500,000 people have died worldwide. It has also catalysed a research... read more

Autopsies Link Immune Response to Death from COVID-19

An autopsy-based study of 11 people who died from COVID-19 shows a mismatch between viral hotspots in the body and sites of inflammation and organ damage, suggesting that immune responses, rather than the virus itself, are... read more

Difficult Bag-Mask Ventilation in Critically Ill Children Is Independently Associated With Adverse Events

Difficult bag-mask ventilation is reported in approximately one in 10 PICU patients undergoing tracheal intubation. Given its association with adverse procedure–related events and oxygen desaturation, future study is warranted... read more

COVID-19 and AKI

Recent reports from China, Italy, and the US indicate that there is a 25-37% incidence of AKI among critically ill COVID-19 patients (Singh 2020, Hirsch et al. 2020). In a study of 5,449 hospitalized COVID-19 patients, acute... read more

A Systematic Review of Risk Factors for Sleep Disruption in Critically Ill Adults

This systematic review summarizes all premorbid, illness-related, and ICU-related factors associated with sleep disruption in the ICU. These findings will inform sleep promotion efforts in the ICU and guide further research... read more

Effect of Dexamethasone in Hospitalized Patients with COVID-19

Although the paper is not even officially published yet, everyone has already heard the results. We have our first treatment that appears to reduce mortality in COVID-19 patients. For a week or so, we only had press release,... read more

Biomarkers of Sepsis: Time for a Reappraisal

The precise roles of most biomarkers in the management of septic patients have not been well defined, and of the many biomarkers that have been studied, only a few have been evaluated in large or repeated studies. As... read more

Lenzilumab Showed Rapid Clinical Improvement in 12 COVID-19 Patients

Humanigen, the clinical stage biopharmaceutical company focused on preventing and treating cytokine storm, has reported positive data from the first clinical use of lenzilumab, its humaneered anti-human granulocyte macrophage-colony... read more

1m Physical Distancing Associated with a Large Reduction in COVID-19 Infection

The findings of this systematic review of 172 studies (44 comparative studies; n=25 697 patients) on COVID-19, SARS, and MERS provide the best available evidence that current policies of at least 1m (3 feet) physical distancing... read more

Common Steroid Reduces Deaths Among Patients with Severe COVID-19

A cheap, readily available steroid drug reduced deaths by a third in patients hospitalized with Covid-19 in a large study, the first time a therapy has been shown to possibly improve the odds of survival with the condition... read more

5 Year Impact of ICU-acquired Neuromuscular Complications

ICU-acquired neuromuscular complications may impact 5-year morbidity and mortality. MRC sum score, even if slightly reduced, may affect long-term mortality, strength, functional capacity and physical function, whereas abnormal... read more

Ethnicity and Outcomes in Patients Hospitalised with COVID-19

Preliminary studies suggest that people from Black, Asian and Minority Ethnic (BAME) backgrounds experience higher mortality from COVID-19 but the underlying reasons remain unclear. Prospective analysis of registry data... read more

Hospital-level Variation in the Development of Persistent Critical Illness

Hospitals with higher risk- and reliability-adjusted 30-day mortality have a higher probability of developing persistent critical illness. Understanding the drivers of this variation may identify modifiable factors contributing... read more

ACEI/ARB Use and Testing Positive for COVID-19

This retrospective cohort study reports that taking either an angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) was not associated with an increase in the likelihood of testing positive... read more

COVID-19 Patients with ARDS Face Significant Financial Effects in Recovery

Long hospitalizations lead to large medical bills, with serious physical and emotional consequences for those recovering from critical illness. It begins with shortness of breath. And for approximately one-third of patients,... read more

WHO Resumes Hydroxychloroquine Study for COVID-19

The World Health Organization is resuming a clinical trial exploring whether the malaria drug hydroxychloroquine can effectively treat COVID-19, after pausing enrollment in the study to review safety concerns about the drug. The... read more

Remdesivir 5-day vs. 10-day Trial Raises Some Red Flags?

Gilead's first Randomized Controlled Trial on remdesivir was just published, and it's very interesting. This is a trial designed, monitored, and written by Gilead. In some ways, the design of the trial and its missing parts... read more

Long-Term Health-Related Quality of Life After Venovenous Extracorporeal Membrane Oxygenation

This study examined the long-term health-related quality of life in adult patients treated with venovenous extracorporeal membrane oxygenation (V-V ECMO) for severe acute respiratory failure in Ireland. A retrospective, cross-sectional... read more

First Report on a First-in-Human Clinical Trial of a Novel Ad5 Vectored COVID-19 Vaccine

This is the first report on a first-in-human clinical trial of a novel Ad5 vectored COVID-19 vaccine. The Ad5 vectored COVID-19 vaccine was tolerated in healthy adults in all three dose groups. The most common adverse... read more

Phenotypic Heterogeneity by Site of Infection in Surgical Sepsis

There are notable differences in baseline predisposition, host responses, and clinical outcomes by site of infection in surgical sepsis. While previous studies have focused on differences in hospital mortality, this study... read more

RAAS Inhibitors and Risk of COVID-19

The authors concluded that RAAS inhibitors do not increase the risk of COVID-19 requiring admission to the hospital, including fatal cases and those admitted to intensive care units (ICUs), and should not be discontinued... read more