Tag: study
1m Physical Distancing Associated with a Large Reduction in COVID-19 Infection
The findings of this systematic review of 172 studies (44 comparative studies; n=25 697 patients) on COVID-19, SARS, and MERS provide the best available evidence that current policies of at least 1m (3 feet) physical distancing... read more
Common Steroid Reduces Deaths Among Patients with Severe COVID-19
A cheap, readily available steroid drug reduced deaths by a third in patients hospitalized with Covid-19 in a large study, the first time a therapy has been shown to possibly improve the odds of survival with the condition... read more
5 Year Impact of ICU-acquired Neuromuscular Complications
ICU-acquired neuromuscular complications may impact 5-year morbidity and mortality. MRC sum score, even if slightly reduced, may affect long-term mortality, strength, functional capacity and physical function, whereas abnormal... read more
Ethnicity and Outcomes in Patients Hospitalised with COVID-19
Preliminary studies suggest that people from Black, Asian and Minority Ethnic (BAME) backgrounds experience higher mortality from COVID-19 but the underlying reasons remain unclear. Prospective analysis of registry data... read more
Hospital-level Variation in the Development of Persistent Critical Illness
Hospitals with higher risk- and reliability-adjusted 30-day mortality have a higher probability of developing persistent critical illness. Understanding the drivers of this variation may identify modifiable factors contributing... read more
ACEI/ARB Use and Testing Positive for COVID-19
This retrospective cohort study reports that taking either an angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) was not associated with an increase in the likelihood of testing positive... read more
COVID-19 Patients with ARDS Face Significant Financial Effects in Recovery
Long hospitalizations lead to large medical bills, with serious physical and emotional consequences for those recovering from critical illness. It begins with shortness of breath. And for approximately one-third of patients,... read more
WHO Resumes Hydroxychloroquine Study for COVID-19
The World Health Organization is resuming a clinical trial exploring whether the malaria drug hydroxychloroquine can effectively treat COVID-19, after pausing enrollment in the study to review safety concerns about the drug. The... read more
Remdesivir 5-day vs. 10-day Trial Raises Some Red Flags?
Gilead's first Randomized Controlled Trial on remdesivir was just published, and it's very interesting. This is a trial designed, monitored, and written by Gilead. In some ways, the design of the trial and its missing parts... read more
Long-Term Health-Related Quality of Life After Venovenous Extracorporeal Membrane Oxygenation
This study examined the long-term health-related quality of life in adult patients treated with venovenous extracorporeal membrane oxygenation (V-V ECMO) for severe acute respiratory failure in Ireland. A retrospective, cross-sectional... read more
First Report on a First-in-Human Clinical Trial of a Novel Ad5 Vectored COVID-19 Vaccine
This is the first report on a first-in-human clinical trial of a novel Ad5 vectored COVID-19 vaccine. The Ad5 vectored COVID-19 vaccine was tolerated in healthy adults in all three dose groups. The most common adverse... read more
Phenotypic Heterogeneity by Site of Infection in Surgical Sepsis
There are notable differences in baseline predisposition, host responses, and clinical outcomes by site of infection in surgical sepsis. While previous studies have focused on differences in hospital mortality, this study... read more
RAAS Inhibitors and Risk of COVID-19
The authors concluded that RAAS inhibitors do not increase the risk of COVID-19 requiring admission to the hospital, including fatal cases and those admitted to intensive care units (ICUs), and should not be discontinued... read more
Simulated COVID-19 Contamination of Health Care Workers After Endotracheal Intubation of Manikins
Despite personal protective equipment, fluorescent markers were found on the uncovered skin, hair, and shoes of participants after simulations of emergency department management of patients experiencing respiratory distress.... read more
Effects of Paracentesis on Hemodynamic Parameters and Respiratory Function in Critically Ill Patients
Paracentesis in critically ill patients is safe regarding hemodynamic function, renal function and intervention-related complications. Furthermore, paracentesis in critically ill and mechanically ventilated patients results... read more
Blood Thinners May Improve Survival Among Hospitalized COVID-19 Patients
Treating hospitalized COVID-19 patients with anticoagulants--blood thinners that slow down clotting--may improve their chances of survival, researchers from the Mount Sinai COVID Informatics Center report. The study,... read more
Patients in Hospital with COVID-19 Using the ISARIC WHO Clinical Characterisation Protocol
ISARIC WHO CCP-UK is a large prospective cohort study of patients in hospital with covid-19. The study continues to enrol at the time of this report. In study participants, mortality was high, independent risk factors were... read more
Transpulmonary Thermodilution Detects Rapid and Reversible Increases in Lung Water Induced by PEEP in ARDS
In ARDS patients, changing the positive end-expiratory pressure (PEEP) level induced parallel, small and reversible changes in EVLW. These changes were not due to an artefact of the TPTD technique and were likely due to the... read more
Prone Positioning in Nonintubated Patients with COVID-19 and Hypoxemic Acute Respiratory Failure
In this study of patients with COVID-19 and hypoxemic respiratory failure managed outside the ICU, 63% were able to tolerate PP for more than 3 hours. However, oxygenation increased during PP in only 25% and was not sustained... read more
Hydroxychloroquine or Azithromycin for COVID-19 Treatment
The use of hydroxychloroquine, azithromycin, or both were not associated with differences in in-hospital mortality. Cardiac arrest was more likely in patients receiving hydroxychloroquine and azithromycin. In this retrospective,... read more
The Utility of Diaphragm Ultrasound in Reducing Time to Extubation
Predicting the optimal time for extubation is challenging, especially in patients with underlying diaphragm dysfunction. Incorporating ultrasound information on diaphragm function into usual care allowed clinicians to identify... read more
Broad Spectrum Vasopressors
We propose the notion of "broad spectrum vasopressors" wherein patients with septic shock are started on multiple vasopressors with a different mechanism of action simultaneously while the vasopressor sensitivity is assessed.... read more
