Tag: study
Impact of Hypophosphatemia on Outcome of Patients in ICU
Hypophosphatemia at admission is an independent risk factor for 28-day mortality in general ICU patients. The cohort included 946 patients with a median phosphate concentration of 0.77 mmol/L. Patients with hypophosphatemia... read more
Hypotensive Response to IV Acetaminophen in Pediatric Cardiac Patients
In isolation of other medication, a hemodynamic response to IV acetaminophen has a higher prevalence in critically ill children with cardiac disease than previously thought and justifies controlled studies in the perioperative... read more
Effects of Baseline Thrombocytopenia and Platelet Decrease Following RRT Initiation in Patients With Severe AKI
Baseline thrombocytopenia and platelet decrease following renal replacement therapy initiation were associated with increased mortality, and baseline thrombocytopenia was associated with decreased rates of renal recovery.... read more
An Innovative Virtual Reality Experience in the PICU
Virtual reality is an innovative, easily administered, and enjoyable tool that subjectively calms PICU patients in an otherwise chaotic environment. 100% of participants enjoyed using virtual reality, and 84% reported preference... read more
Who May Benefit Most From Future Vitamin D Intervention Trials
High-dose vitamin D3 supplementation was associated with a reduction of 28-day mortality in a mixed population of critically ill adults with vitamin D deficiency when excluding patients who died or were discharged within... read more
Validation and Critical Evaluation of the Effective Arterial Elastance in Critically Ill Patients
In critically ill patients, effective arterial elastance may be reliably estimated at bedside. We support the use of this validated estimate of effective arterial elastance when coupled with an index of left ventricular contractility... read more
Huddling for High Reliability and Situation Awareness
This study objectives were to explore hospital administrator and frontline staff perspectives on the benefits and challenges of implementing a tiered huddle system; and propose a model based on our findings depicting the... read more
What influences critical care doctors in withdrawing life support for patients with brain injury?
Decisions to withdraw life support treatments in critically ill patients with severe brain injury are complicated, are based on many factors, and are usually made by critical care physicians and families in the intensive... read more
Post-discharge Impact of Healthcare-associated Infections in a Developing Country
The impact of healthcare-associated infections (HCAIs) on in-hospital mortality, morbidity, length-of-stay, and costs has been extensively reported. However, few studies have focused on the follow-up of HCAI-affected subjects... read more
Using Propensity Scoring Analyses in Critical Care Research
Observational studies are a common and important aspect of critical care research. A key challenge in the design of observational studies is the control of confounding. Confounding arises when the groups being compared in... read more
Impact of Weekly Case-based Tele-education on Quality of Care in a Limited Resource Medical ICU
Limited critical care subspecialty training and experience is available in many low- and middle-income countries, creating barriers to the delivery of evidence-based critical care. We hypothesized that a structured tele-education... read more
Midazolam Dose Optimization in Critically Ill Pediatric Patients with ARF
This work leveraged available knowledge on non-heritable and heritable factors affecting midazolam pharmacokinetic in pediatric subjects with primary respiratory failure requiring mechanical ventilation, providing the basis... read more
Evaluation of a Safer Opioid Prescribing Protocol (SOPP) for Patients Being Discharged From a Trauma Service
The aims of this study were to evaluate the effects on opioid medication prescribing, patient opioid safety education, and prescribing of naloxone following implementation of a Safer Opioid Prescribing Protocol (SOPP) as... read more
Association of Age With Short-term and Long-term Mortality Among Patients Discharged From ICUs in France
Results of this study suggest that aging was associated with an increased risk of mortality in the 3 years after hospital discharge that included an ICU admission, with a sharp increase in those 80 years and older. However,... read more
Level and Prevalence of Spin in Published Cardiovascular Randomized Clinical Trial Reports With Statistically Nonsignificant Primary Outcomes
In this systematic review that included 93 reports of Randomized Clinical Trials (RCTs) from 6 high-impact journals, positive spin of statistically nonsignificant primary outcomes was found in 57% of abstracts and 67% of... read more
Clinician Perception of a Machine Learning–Based Early Warning System Designed to Predict Severe Sepsis and Septic Shock
In general, clinical perceptions of Early Warning System 2.0 were poor. Nurses and providers differed in their perceptions of sepsis and alert benefits. These findings highlight the challenges of achieving acceptance of predictive... read more
Pretreating red blood cells with nitric oxide may reduce side effect linked to transfusions
A new treatment may diminish a dangerous side effect associated with transfusions of red blood cells (RBCs) known as pulmonary hypertension, an elevated blood pressure in the lungs and heart that can lead to heart failure.... read more
Closed Chest Compressions in Traumatic Cardiac Arrest
This study demonstrated that fluid resuscitation with whole blood is significantly better than resuscitation with compressions alone or with normal saline. It further showed that there was no difference between whole blood... read more
