Think Sepsis and Act Fast

New attention to sepsis including revised definitions, updated guidelines, and new CMS reporting requirements aims to save lives through prevention and prompt and effective management of infections. CDC released a new Vital... read more

Upright CT for lung cancer therapy planning used at Chicago Proton Center

The Northwestern Medicine Chicago Proton Center will be the first proton center in the U.S. to use P-Cure new P-ARTIS CT on patients being treated for lung cancer. Traditionally, patients lie flat on their backs during CT... read more

Therapy Implications for Immunomodulation After Ischemic Stroke

Despite significant advances towards a better understanding of the pathophysiology of ischemic stroke-induced immunosuppression and SAP in recent years, many unanswered questions remain. The true incidence and outcomes of... read more

Three-year mortality in 30 day survivors of critical care with AKI

Acute kidney injury was not an independent risk factor for 3-year mortality among 30-day survivors. Increased 3-year mortality among patients with AKI who survive critical illness may not be related to AKI per se, but rather... read more

Antibiotic therapy advances in the critically ill

Key issues related to antibiotic management in the critically ill, including problems associated with timing, duration, and dosing of antibiotics. The authors highlighted the importance of early diagnosis of infection and... read more

Drugs Don’t Cut Trastuzumab-Tied Left Ventricular Remodeling

The researchers found that the drugs were well tolerated, with no serious adverse events reported. The indexed left ventricular end diastolic volume increased in patients treated with perindopril, bisoprolol, and placebo... read more

Warding off Fight, Flight, or Freeze

There's some evidence that suggests that just by telling people the physiological facts about stress, this is why you get tunnel vision, this is why you can't remember drug doses or what's next in the algorithm... read more

Benefits of PCI for STEMI Not Attenuated in Patients With a Cancer History

Having a history of cancer does not worsen outcomes for patients with STEMI who undergo primary PCI and should not be a barrier to revascularization and optimal therapy.... read more

Targeted Drug Delivery using Porous Glass Microspheres

Finding ways to improve efficiency and bioavailability is key to targeted drug delivery. Although controlled release dosage medication forms are the standard, they can have certain limitations.... read more

Negative pressure irrigation and endoscopic necrosectomy through man-made sinus tract in infected necrotizing pancreatitis

This four-step approach is effective in treating IPN and adds no extra risk to patients when compared with other latest step-up strategies. The two novel techniques (NPI and ED) could offer distinct clinical benefits without... read more

Combined Data Show Superiority of LAMA/LABA in COPD

Patients with chronic obstructive pulmonary disease (COPD) experienced significantly fewer acute exacerbations when a long-acting muscarinic antagonist (LAMA) was added to a long-acting beta agonist (LABA) than when an inhaled... read more

New Cytokine Approach is Synergistic With Checkpoint Inhibitors

Among the new agents currently being explored in clinical trials, NKTR-214 stands out as a new cytokine therapy approach that could show additive benefit when combined with checkpoint inhibitors. ... read more

Nonadherence to Meds Hurts NSTEMI Patients, Especially After PCI

Patients who were revascularized for a non-ST-segment elevation myocardial infarction (NSTEMI) did better if they adhered to their medications.... read more

One-Third of Hypertension Patients Noncompliant with Therapy

More than 30% of patients with hypertension do not adhere to their antihypertensive drug therapy, according to a new study.... read more

FDA Approves Defibrillator That Automatically Adjusts Pacing

The FDA has cleared the Claria MRI Quad Cardiac Resynchronization Therapy Defibrillator (CRT-D) SureScan device (Medtronic) for patients with heart failure.... read more

Bariatric surgery may protect against heart failure

Bariatric surgery appears to reduce substantially the risk of heart failure.... read more

Bacteriophages cure bacterial infections

Phage therapy may be a solution to treating infections caused by antibiotic-resistant bacteria. Since 2013, researchers at the University of Helsinki in Finland have collected bacteriophages to combat antibiotic-resistant... read more

PCSK9 Inhibition and Other New Therapies for Lipid Modification: Good News and Bad

A late-breaking clinical trial session devoted to newly approved and investigational compounds for the treatment of lipids highlighted the end of a once promising therapy for low HDL cholesterol.... read more

FDA Approves Carnexiv Injection for Seizures

The FDA has approved Carnexiv (carbamazepine) injection as a short-term replacement therapy for oral carbamazepine formulations for adults with certain seizure types.... read more

Guidelines for Neuromuscular Blockade in the Adult Critically Ill Patient

The Society of Critical Care Medicine recently released guidelines addressing sustained neuromuscular blockade in the adult critically ill patient.... read more

FDA to radiologists: stop using any Multidata Systems devices

At least two devices distributed in U.S. without FDA approval. There have been at least two Multidata medical devices that the company manufactured and distributed in the United States for which FDA never received nor reviewed... read more

5 New Oral Anticoagulants for Atrial Fibrillation

When trying to decide which therapy for nonvalvular atrial fibrillation (NVAF) is optimal for patients, many factors should be considered, including compliance, ability to perform daily activities of living, and nutrition... read more