The Harriet Lane Handbook: Mobile Medicine Series

Written "by residents, for residents" and reviewed by expert faculty at The Johns Hopkins Hospital, Lauren Kahl, MD and Helen K. Hughes, MD, MPH, The Harriet Lane Handbook, 21st Edition, remains your #1 source of pediatric... read more

The Harriet Lane Handbook: Mobile Medicine Series

Variations in End-of-Life Practices in ICUs Worldwide

Limitation of life-sustaining therapies is common worldwide with regional variability. Withholding treatment is more common than withdrawing treatment. Variations in type, frequency, and timing of end-of-life decisions were... read more

Eosinophilic Esophagitis

Once considered a rare condition, eosinophilic esophagitis is now one of the most common conditions diagnosed during the assessment of feeding problems in children and during the evaluation of dysphagia and food impaction... read more

Carotid Blowout Syndrome: Modern Trends in Management

Carotid blowout syndrome (CBS) refers to rupture of the carotid artery and is an uncommon complication of head and neck cancer that can be rapidly fatal without prompt diagnosis and intervention. CBS develops when a damaged... read more

Electrical Storm and Incessant Ventricular Tachycardia

Electrical storm, also referred to as arrhythmic storm, refers to multiple recurrences of ventricular arrhythmias over a short period of time. In most instances, the arrhythmia is ventricular tachycardia (VT), but polymorphic... read more

Intensive care–treated cardiac arrest: a retrospective study on the impact of extended age on mortality, neurological outcome, received treatments and healthcare-associated costs

The elderly ICU-treated CA patients in this study had worse neurological outcomes, higher mortality and lower cost-effectiveness than younger patients. Elderly received less intense treatment. Further efforts are needed... read more

COVID-19: a boost for intensive care authorship?

Almost 180 million cases of COVID-19 have been diagnosed, with almost 4.000.000 deaths. Since this pandemic had unprecedented worldwide healthcare and socio-economic effects, the scientific world is under exceptional pressure... read more

The Gut in COVID‑19

In the last year, a growing number of articles addressed coronavirus disease 2019 (COVID-19), including its link with gastrointestinal (GI) (dys)function. We here highlight the most important findings regarding the role of... read more

Transcatheter arterial embolization for severe blunt liver injury in hemodynamically unstable patients

Transcatheter arterial embolization (TAE) in hemodynamically unstable patients who responded to initial infusion therapy to some extent has acceptable in-hospital mortality and clinical failure rates. Hemodynamic instability... read more

Effect of Graded Early Mobilization on Psychomotor Status and Length of ICU Stay in Mechanically Ventilated Patients

This research showed that graded early mobilization was highly effective to improve the motor and psychological status of mechanically ventilated patients and reduce their length of ICU stay. In the control group mean... read more

Prone Positioning and Survival in Mechanically Ventilated Patients with COVID-19

In-hospital mortality was lower in mechanically ventilated hypoxemic patients with coronavirus disease 2019 treated with early proning compared with patients whose treatment did not include early proning. Among 2,338 eligible... read more

COVID-19 Surges Increased Patient Mortality

A recent study by scientists at the National Institutes of Health suggests that one in every four COVID-19 deaths in the United States may be attributed to hospitals strained by surging caseloads. Published in the Annals... read more

Reduced Sensitivity of COVID-19 Variant Delta to Antibody Neutralization

The SARS-CoV-2 B.1.617 lineage was identified in October 2020 in India1–5. It has since then become dominant in some indian regions and UK and further spread to many countries6. The lineage includes three main subtypes... read more

Melatonin for Delirium Prevention in Hospitalized Patients

Melatonin/ramelteon are associated with reduction in delirium incidence in hospitalized patients. However, this effect seems confined to surgical and ICU patients. The optimum dosage and formulation of melatonin, and... read more

Preoperative vena cava filter placement in recurrent cerebral fat embolism following traumatic multiple fractures

Despite scarce evidence, we reckon that Inferior Vena Cava Filter (IVCF) could improve prognosis in selected patients with fat embolism syndrome (FES), especially those presenting high risk factors, after accurately weighing... read more

REGN monoclonal antibodies work in selected hospitalised COVID-19 patients

New findings suggest a significant benefit from REGN in terms of the primary outcome of mortality for patients who have low levels of their own antibodies at the time of admission. This was an unexpected result for me... read more

RIG-1 Agonist Shows Potent Antiviral Efficacy Against COVID-19

As SARS-CoV-2 continues to cause morbidity and mortality around the world, there is an urgent need for the development of effective medical countermeasures. Here, we assessed the antiviral capacity of a minimal RIG-I... read more

Imatinib in COVID-19: Hope and Caution

Despite the undoubted progress achieved with the first vaccines against SARS-CoV-2 infection, the COVID-19 pandemic continues to affect thousands of people across the globe, particularly in those countries where vaccination... read more

ICP Monitoring in Patients with Acute Brain Injury

The use of intracranial pressure (ICP) monitoring and ICP management varies greatly across centres and countries. The use of ICP monitoring might be associated with a more intensive therapeutic approach and with lower 6-month... read more

The Relationship of Delirium, Sedation, Dementia, and Acquired Weakness

The advent of modern critical care medicine has revolutionized care of the critically ill patient in the last 50 years. The Society of Critical Care Medicine (was formed in recognition of the challenges and need for specialized... read more

Aerosolised Surfactant Trial for Preterm Infants with RDS

The AeroFact system can safely deliver aerosolised surfactant to preterm infants with respiratory distress syndrome (RDS) who are on nasal continuous positive airway pressure (nCPAP). 10 infants were enrolled in part 1... read more

What the Flecainide is going on here?

A 54-year-old woman is brought to the emergency department for palpitations. In triage she has a heart rate of 120 bpm, BP 143/89, SpO2 99%. Shortly after being roomed, she begins to complain of worsening symptoms and looks... read more