Tag: trial
Old vs New: End of Debate on Blood Transfusion Storage
The new data come from the Informing Fresh versus Old Red Cell Management (INFORM) trial, which assigned hospitalized patients to receive transfusion of the freshest red cells in the inventory.... read more
Baxter initiates late-stage study of novel therapy for acute kidney injury
Baxter International commences a Phase 3 clinical trial assessing an investigational drug, Prismocitrate 18, that combines a citrate anticoagulant and renal replacement solution.... read more
Abdominal Aortic Aneurysm Screening
The long-term follow-up of the Western Australian trial of screening for abdominal aortic aneurysms (AAAs) reported in this issue of JAMA Internal Medicine1 is likely the last report from the 4 randomized clinical trials1- 4... read more
Spontaneous breathing trial and post-extubation work of breathing in morbidly obese critically ill patients
Predicting whether an obese critically ill patient can be successfully extubated may be specially challenging. Several weaning tests have been described but no physiological study has evaluated the weaning test that would... read more
Hospitals embed mental health professionals in the ICU
Pilot programs at several large academic medical centers suggest that integrating psychiatrists and other mental-health professionals into hospital units.... read more
Acute caffeine ingestion does not increase arrhythmias in patients with chronic systolic heart failure
Acute ingestion of caffeine did not increase the risk of ventricular or supraventricular arrhythmias as compared to placebo in patients with chronic systolic heart failure, either at rest or during a symptom-limited exercise... read more
Hydrocortisone treatment in early sepsis-associated acute respiratory distress syndrome
In sepsis-associated ARDS, hydrocortisone treatment was associated with a significant improvement in pulmonary physiology, but without a significant survival benefit.... read more
Blood products and procoagulants in traumatic bleeding
A host of preclinical and clinical studies have evaluated blood product availability and efficacy in trauma. Recently published randomized controlled trials have investigated the ratio of platelet:plasma:red cell transfusion... read more
Palliative-care boosts heart failure patient outcomes
Adding palliative care interventions to management of patients with advanced heart failure improved quality-of-life measures in two relatively small, controlled studies.... read more
More NOAC Comparisons See More Bleeding With Rivaroxaban: Is the ‘Writing on the Wall’?
Evidence is mounting, albeit from observational studies, that while all of the non-vitamin K antagonist oral anticoagulants (NOACs) appear to have similar efficacy in terms of stroke reduction in atrial fibrillation, they... read more
Levosimendan Doesn’t Prevent Acute Organ Dysfunction
For adults with sepsis, levosimendan does not prevent acute organ dysfunction.... read more
Conservative oxygen treatment linked to lower ICU mortality
A conservative protocol for oxygen therapy results in lower intensive care unit (ICU) mortality compared to conventional care.... read more
New HIV treatment appears to have fully erased the virus from a patient's blood
A pioneering new trial offers new hope in the fight against HIV after a patient treated with a new therapy appears to have no trace of the virus in their blood.... read more
Adjunctive azithromycin reduces risk of non-elective cesarean post-operative infection: The C/SOAP trial
Women receiving azithromycin in addition to standard antibiotic prophylaxis for cesarean section (c-section) were 49% less likely to develop endometritis and postoperative wound infections compared to those who received only... read more
Use of interventions improves patient care for viral hepatitis
Researchers recommend multiple, inexpensive interventions be included in screening, diagnosis and treatment programs for patients with hepatitis B and C viruses, in an effort to optimize the outcomes of hepatitis care.... read more
