ICU Utilization for Patients With Acute Exacerbation of COPD Receiving Noninvasive Ventilation

There is wide variability in the rate of ICU utilization for noninvasive ventilation across hospitals. Chronic obstructive pulmonary disease (COPD) patients receiving noninvasive ventilation had similar in-hospital mortality... read more

ICU Utilization for Patients With Acute Exacerbation of COPD Receiving Noninvasive Ventilation

DeepSOFA: A Continuous Acuity Score for Critically Ill Patients using Clinically Interpretable Deep Learning

Traditional methods for assessing illness severity and predicting in-hospital mortality among critically ill patients require time-consuming, error-prone calculations using static variable thresholds. These methods do not... read more

DeepSOFA: A Continuous Acuity Score for Critically Ill Patients using Clinically Interpretable Deep Learning

Effect of high-flow nasal cannula oxygen therapy in adults with acute hypoxemic respiratory failure

Conflicting recommendations exist on whether high-flow nasal cannula (HFNC) oxygen therapy should be administered to adult patients in critical care with acute hypoxemic respiratory failure. We performed a meta-analysis of... read more

Effect of high-flow nasal cannula oxygen therapy in adults with acute hypoxemic respiratory failure

One of the Deadliest Hospital-Acquired Infections Is Preventable

Johns Hopkins Study Shows One of the Deadliest Hospital-Acquired Infections Is Preventable. For some hospital patients, going on a ventilator is often the difference between life and death. About 800,000 hospital patients... read more

One of the Deadliest Hospital-Acquired Infections Is Preventable

High-frequency Oscillatory Ventilation: Still a Role?

In light of emerging data from clinical trials, the place of high-frequency oscillatory ventilation (HFOV) in the management of acute respiratory distress syndrome (ARDS) is uncertain. Although not first-line, HFOV remains... read more

High-frequency Oscillatory Ventilation: Still a Role?

Relationship Between Level of CPR Training, Self-reported Skills, and Actual Manikin Test Performance

As expected, higher levels of BLS training correlated with better cardiopulmonary resuscitation (CPR) quality. However, this study showed that ventilations and hands-on time were the components of CPR that were most affected... read more

Relationship Between Level of CPR Training, Self-reported Skills, and Actual Manikin Test Performance

Cricoid Pressure in Airway Management: The IRIS Trial

This large randomized clinical trial performed in patients undergoing anesthesia with RSI failed to demonstrate the non-inferiority of the sham procedure in preventing pulmonary aspiration. Further studies are required in... read more

Cricoid Pressure in Airway Management: The IRIS Trial

The Benefit of Lung-Protective Ventilation in the ED

Intubation and mechanical ventilation are commonly performed ED interventions and although patients optimally go to an ICU level of care afterwards, many of them remain in the ED for prolonged periods of time. It is widely... read more

The Benefit of Lung-Protective Ventilation in the ED

A Familiar Story: Delirium in the Acute Care Setting

A few years ago, I received report that a patient was ready to be weaned from the ventilator. He had no respiratory need for mechanical ventilation, and every time the medical team attempted to wean sedation to extubate,... read more

A Familiar Story: Delirium in the Acute Care Setting

Prospective Assessment of the Feasibility of a Trial of Low Tidal Volume Ventilation for Patients with Acute Respiratory Failure

Use of initial tidal volumes less than 8 ml/kg PBW is common at hospitals participating in the NHLBI PETAL Network. After considering the size and budgetary requirement for a cluster-randomized trial of LTVV vs. usual care... read more

Prospective Assessment of the Feasibility of a Trial of Low Tidal Volume Ventilation for Patients with Acute Respiratory Failure

Decontaminants Don’t Cut Bloodstream Infection Risk in Ventilated ICU Patients

The use of digestive and oral decontaminants in patients in the intensive care unit (ICU) who are mechanically ventilated and who have moderate to high antibiotic resistance is not associated with a reduction in ICU-acquired... read more

Decontaminants Don’t Cut Bloodstream Infection Risk in Ventilated ICU Patients

Sedation and Neurodevelopmental Outcomes in PICU

As little as 30 minutes of exposure to anesthetic and sedative agents may adversely affect the developing brain. Safe, humane management of critically ill infants requires the use of sedative agents, often for prolonged periods.... read more

Sedation and Neurodevelopmental Outcomes in PICU

Critical Care Medicine: The Essentials and More

With a full-color design and concise, easy-to-read chapters, Critical Care Medicine: The Essentials and a Bit More covers the core elements of critical care, with a unique focus on the pathophysiology underlying clinical... read more

Critical Care Medicine: The Essentials and More

Effect of Bag-Mask Ventilation vs Endotracheal Intubation During CPR on Neurological Outcome After OHCA

Among patients with out-of-hospital cardiorespiratory arrest (OHCA), the use of BMV compared with ETI failed to demonstrate noninferiority or inferiority for survival with favorable 28-day neurological function, an inconclusive... read more

Effect of Bag-Mask Ventilation vs Endotracheal Intubation During CPR on Neurological Outcome After OHCA

Impact of Drug and Equipment Preparation on Pre-hospital Emergency Anesthesia Procedural Time, Error Rate and Cognitive Load

Pre-preparation of Preparation on Pre-hospital Emergency (PHEA) equipment and drugs resulted in safer performance of PHEA and has the potential to reduce on-scene time by up to a third. In total 23 experiments were completed,... read more

Impact of Drug and Equipment Preparation on Pre-hospital Emergency Anesthesia Procedural Time, Error Rate and Cognitive Load

Improving Hospital Survival and Reducing Brain Dysfunction at Seven California Community Hospitals

The evidence-based ABCDEF bundle was successfully implemented in seven community hospital ICUs using an interprofessional team model to operationalize the Pain, Agitation, and Delirium guidelines. Higher bundle compliance... read more

Improving Hospital Survival and Reducing Brain Dysfunction at Seven California Community Hospitals

A retrospective observational study of acquired subglottic stenosis using low-pressure, high-volume cuffed endotracheal tubes

The safety of cuffed endotracheal tubes in the neonatal and critically ill pediatric population continues to be questioned due to the theoretical risk of acquired subglottic stenosis. The incidence of acquired subglottic... read more

A retrospective observational study of acquired subglottic stenosis using low-pressure, high-volume cuffed endotracheal tubes

Electrical Impedance Tomography in ARDS

Acute respiratory distress syndrome (ARDS) is a clinical entity that acutely affects the lung parenchyma, and is characterized by diffuse alveolar damage and increased pulmonary vascular permeability. Currently, computed... read more

Electrical Impedance Tomography in ARDS