Oxygen: Savior or Devil in a Green Dress?

If you ask any small child what doctors do or what happens in a hospital, you'll probably get some variation of "they make sick people better." Were you to ask the same question of one of those doctors or someone working... read more

Oxygen: Savior or Devil in a Green Dress?

Scavenging Circulating Mitochondrial DNA as a Potential Therapeutic Option for Multiple Organ Dysfunction in Trauma Hemorrhage

Trauma is a leading cause of death worldwide with 5.8 million deaths occurring yearly. Almost 40% of trauma deaths are due to bleeding and occur in the first few hours after injury. Of the remaining severely injured patients... read more

Scavenging Circulating Mitochondrial DNA as a Potential Therapeutic Option for Multiple Organ Dysfunction in Trauma Hemorrhage

Limiting Sedation for Patients with ARDS

Current evidence supports the use of protocol-based, light-sedation strategies in critically ill patients with ARDS. Further research into sedation management specifically in ARDS populations is needed. Deep sedation strategies... read more

Limiting Sedation for Patients with ARDS

Advances in Critical Care Management of Patients Undergoing Cardiac Surgery

Cardiac surgery has been evolving to include minimally invasive, hybrid and transcatheter techniques. Increas‑ing patient age and medical complexity means that critical care management needs to adapt and evolve. Recent... read more

Advances in Critical Care Management of Patients Undergoing Cardiac Surgery

Mechanical Ventilation: Physiological and Clinical Applications

Known for its simple explanations and in-depth coverage of patient-ventilator management, this evidence-based text walks readers through the most fundamental and advanced concepts surrounding mechanical ventilation and guides... read more

Mechanical Ventilation: Physiological and Clinical Applications

The A1 Sedation Package: Better Care for Intubated Patients

You are called to the scene of a 56-year-old male found unresponsive in his garage workshop. Upon examining him you find him minimally responsive to painful stimulus, moaning and groaning. His family tells you he has high... read more

The A1 Sedation Package: Better Care for Intubated Patients

Fluid Bolus Over 15-20 Versus 5-10 Minutes Each in the First Hour of Resuscitation in Children With Septic Shock

Children receiving fluid boluses over 5–10 minutes each had a higher risk of intubation than those receiving boluses over 15–20 minutes each. Notwithstanding the lack of difference in risk of mortality and the possibility... read more

Fluid Bolus Over 15-20 Versus 5-10 Minutes Each in the First Hour of Resuscitation in Children With Septic Shock

Comparing Effects Between Music Intervention and Aromatherapy on Anxiety of Patients Undergoing Mechanical Ventilation in the ICU

Music and aromatherapy interventions were both effective for ICU patients. The effects of music intervention were greater than that of aromatherapy; both interventions maintained the effects for at least 30 min. The Music... read more

Comparing Effects Between Music Intervention and Aromatherapy on Anxiety of Patients Undergoing Mechanical Ventilation in the ICU

When to Withdraw Resuscitation in the ED

When can and should we withdraw from continuing resuscitation in the Emergency Department? We are here to save lives. I would argue the Emergency Medicine is a very pure expression of a Doctor's role: we meet a patient, we... read more

One-Year Outcomes in Patients With ARDS

Poor functional recovery after invasive mechanical ventilation for acute respiratory distress syndrome is common. Helmet noninvasive ventilation may be the first intervention that mitigates the long-term complications that... read more

One-Year Outcomes in Patients With ARDS

Adaptive servo ventilation cuts atrial fib burden

Adaptive servo ventilation produced a significant and clinically meaningful reduction in atrial fibrillation burden in patients with heart failure and sleep apnea in results from an exploratory, prospective, randomized study... read more

Adaptive servo ventilation cuts atrial fib burden

Intra-Abdominal Hypertension Is More Common Than Previously Thought

Intra-abdominal hypertension is common in both surgical and nonsurgical patients in the intensive care setting and was found to be independently associated with mortality. Despite prior reports to the contrary, intra-abdominal... read more

Intra-Abdominal Hypertension Is More Common Than Previously Thought

High-Flow Nasal Cannula in Critically Ill Subjects With or at Risk for Respiratory Failure

High-flow nasal cannula (HFNC) oxygen delivery has been gaining attention as an alternative means of respiratory support for critically ill patients, with recent studies suggesting equivalent outcomes when compared with other... read more

High-Flow Nasal Cannula in Critically Ill Subjects With or at Risk for Respiratory Failure

Criteria for Identifying Lung Injury Prior to the Need for Positive Pressure Ventilation

Mortality associated with acute lung injury (ALI) remains high. Early identification of ALI prior to onset of respiratory failure may provide a therapeutic window to target in future clinical trials. This study empirically... read more

Criteria for Identifying Lung Injury Prior to the Need for Positive Pressure Ventilation

Tracheotomy in the ICU: Guidelines from a French Expert Panel

Tracheotomy is widely used in intensive care units (ICUs), albeit with great disparities between medical teams in terms of frequency and modality. Indications and techniques are, however, associated with variable levels of... read more

Tracheotomy in the ICU: Guidelines from a French Expert Panel

Apneic Oxygenation in the ICU

Hypoxemia is the most common complication of endotracheal intubation in the critically ill and the strongest risk factor for periprocedural cardiac arrest and death. The traditional approach to avoiding desaturation during... read more

Apneic Oxygenation in the ICU

Associations With Psychological Outcomes Among Family Members of Mechanical Ventilation Survivors

In this multicenter cross-sectional survey, we interviewed family members of mechanically ventilated patients at the time of transfer from the ICU to the hospital ward. To our knowledge, this is the first study to explore... read more

Associations With Psychological Outcomes Among Family Members of Mechanical Ventilation Survivors

Does Respiratory Variation Of Inferior Vena Cava Diameter Predict Fluid Responsiveness In Spontaneously Ventilating Children With Sepsis

IVC collapsibility has poor test characteristics for predicting fluid responsiveness in spontaneously ventilating children with sepsis. Thirty-nine fluid boluses were recorded in 33 children, 28/39 (72%) of which met criteria... read more

Does Respiratory Variation Of Inferior Vena Cava Diameter Predict Fluid Responsiveness In Spontaneously Ventilating Children With Sepsis