Delayed Intubation Linked to Poor Outcome

The optimal timing of endotracheal intubation in critically ill patients requiring invasive mechanical ventilation remains undefined. A new analysis of the large, prospective Intensive Care Over Nations (ICON) database compares... read more

Early Identification of Acute Respiratory Distress Disorder in the Absence of Positive Pressure Ventilation

Almost all patients with pulmonary bilateral infiltrates and a PaO2/FIO2 less than or equal to 300 mm Hg under standard oxygen fulfilled the acute respiratory distress syndrome criteria under noninvasive ventilation within... read more

Implementation of a Goal-Directed Mechanical Ventilation Order Set Improves Compliance

Implementation of a Goal-Directed Mechanical Ventilation Order Set Driven by Respiratory Therapists Improves Compliance With Best Practices for Mechanical Ventilation. Data regarding best practices for ventilator management... read more

Optimal Approach to Mechanical Ventilation After Cardiac Arrest

Return of spontaneous circulation after cardiac arrest results in a systemic inflammatory state called the post-cardiac arrest syndrome (PCAS), characterised by oxidative stress, coagulopathy, neuronal injury, and organ dysfunction.... read more

Acute Hypoxemic Respiratory Failure in Immunocompromised Patients

In immunocompromised patients with acute hypoxemic respiratory failure (ARF), initial management aims primarily to avoid invasive mechanical ventilation (IMV). HFNC has an effect on intubation but not on mortality rates.... read more

Workup, Management, and Critical Sequelae of Burn Injuries

Richard Iuorio, MD speaks with Laura Johnson, MD, and Jim Reilly, MD, about the workup, management, and critical sequelae of burn injuries. Using a fictional burn case as an example, Dr. Johnson talks about airway considerations,... read more

Initial Nutritional Management During NIV and Outcomes

Patients starting noninvasive ventilation (NIV) to treat acute respiratory failure are often unable to eat and therefore remain in the fasting state or receive nutritional support. Nearly three-fifths of patients receiving... read more

Corticosteroid Therapy for Critically Ill Patients with the MERS

Corticosteroid therapy in patients with Middle East Respiratory Syndrome (MERS) was not associated with a difference in mortality after adjustment for time-varying confounders, but was associated with delayed MERS coronavirus... read more

Excess Ventilation in COPD-Heart Failure Overlap

Heightened neural drive promoting a ventilatory response beyond that required to overcome an increased "wasted" ventilation led to hypocapnia and poor exercise ventilatory efficiency in chronic obstructive pulmonary disease–heart... read more

Hospital Factors May Influence NIV Outcomes Even in Low-Evidence Use

Strong evidence supports use of noninvasive ventilation (NIV) for patients with respiratory distress from chronic obstructive pulmonary disease and heart failure – i.e., strong evidence conditions (SECs). A new study of... read more

Enteral vs. Parenteral Early Nutrition in Ventilated Adults with Shock

In critically ill adults with shock, early isocaloric enteral nutrition did not reduce mortality or the risk of secondary infections but was associated with a greater risk of digestive complications compared with early isocaloric... read more

Furosemide in the Treatment of Acute Pulmonary Edema

CHF is a common problem in the US with over 5 million patients carrying the diagnosis and 500,000 new diagnoses each year.1 Cardiogenic acute pulmonary edema (APE) occurs when blood backs up into the pulmonary vasculature... read more

Continuing Rehabilitation After ICU Discharge

This article discusses technological innovations that promote survival and enhance recovery, starting within the ICU with developments in ventilation, sedation, early mobility and ICU design. Post-ICU, the establishment of... read more

Face Mask vs Helmet for Noninvasive Ventilation

In Reply Drs Taccone and Chiumello state that physicians must understand the helmet’s physiologic behavior in terms of CO2 rebreathing to ensure safety. Neurological impairment led to intubation in 5 of the 8 intubated... read more

Drug does not significantly reduce duration of mechanical ventilation for COPD patients

Among mechanically ventilated patients with COPD, administration of the respiratory stimulant acetazolamide did not significantly reduce the duration of invasive mechanical ventilation.... read more

Noninvasive Ventilation in Patients With Hematologic Malignancy

Two-thirds of patients with Hematologic Malignancy and respiratory failure failed Noninvasive Ventilation (NIV) and required endotracheal intubation, and had high subsequent mortality. Patients who failed NIV had higher Paco2,... read more

Airway Management of The Morbidly Obese Patient

Obesity is a major health care dilemma. All aspects of medical care, including anesthesia, are affected by it. All physiologic systems are altered by obesity, which imparts a higher risk for complications in the perioperative... read more

Hyperventilation Therapy for Control of Post-Traumatic Intracranial Hypertension

During traumatic brain injury, intracranial hypertension (ICH) can become a life-threatening condition if it is not managed quickly and adequately. Physicians use therapeutic hyperventilation to reduce elevated intracranial... read more

Avoiding Intubation

Review the basic principles and physiology of Non-Invasive Ventilation and High-Flow Oxygen Systems. Critical Care Summit talk by William Bender, MD, Assistant Professor of Pulmonary and Critical Care Emory University School... read more

External Validity of Electronic Sniffers for Automated Recognition of ARDS

Automated electronic sniffers may be useful for early detection of acute respiratory distress syndrome (ARDS) for institution of treatment or clinical trial screening. Published electronic sniffer algorithms for ARDS may... read more

Ventilation Rate During Adult CPR with Tracheal Tube

The optimal ventilation rate during cardiopulmonary resuscitation (CPR) with a tracheal tube is unknown. A new systematic review finds that a ventilation rate recommendation of 10 min-1 during adult CPR with a secure airway... read more

Non-invasive Ventilation for the Management of AHRF due to Exacerbation of COPD

Non-invasive ventilation (NIV) with bi-level positive airway pressure (BiPAP) is commonly used to treat patients admitted to hospital with acute hypercapnic respiratory failure (AHRF) secondary to an acute exacerbation of... read more