Criteria for Identifying Lung Injury Prior to the Need for Positive Pressure Ventilation

Criteria for Identifying Lung Injury Prior to the Need for Positive Pressure Ventilation

Mortality associated with acute lung injury (ALI) remains high. Early identification of ALI prior to onset of respiratory failure may provide a therapeutic window to target in future clinical trials. This study empirically... read more

Tracheotomy in the ICU: Guidelines from a French Expert Panel

Tracheotomy in the ICU: Guidelines from a French Expert Panel

Tracheotomy is widely used in intensive care units (ICUs), albeit with great disparities between medical teams in terms of frequency and modality. Indications and techniques are, however, associated with variable levels of... read more

Apneic Oxygenation in the ICU

Apneic Oxygenation in the ICU

Hypoxemia is the most common complication of endotracheal intubation in the critically ill and the strongest risk factor for periprocedural cardiac arrest and death. The traditional approach to avoiding desaturation during... read more

Associations With Psychological Outcomes Among Family Members of Mechanical Ventilation Survivors

Associations With Psychological Outcomes Among Family Members of Mechanical Ventilation Survivors

In this multicenter cross-sectional survey, we interviewed family members of mechanically ventilated patients at the time of transfer from the ICU to the hospital ward. To our knowledge, this is the first study to explore... read more

Does Respiratory Variation Of Inferior Vena Cava Diameter Predict Fluid Responsiveness In Spontaneously Ventilating Children With Sepsis

Does Respiratory Variation Of Inferior Vena Cava Diameter Predict Fluid Responsiveness In Spontaneously Ventilating Children With Sepsis

IVC collapsibility has poor test characteristics for predicting fluid responsiveness in spontaneously ventilating children with sepsis. Thirty-nine fluid boluses were recorded in 33 children, 28/39 (72%) of which met criteria... read more

Oxygen Flow Rate and FiO2: Understand the Relationship!

Oxygen Flow Rate and FiO2: Understand the Relationship!

Oxygen, we all need it! We do not need a lot of it under normal circumstances, with 0.21 being the fraction of inspired oxygen (FiO2) of room air. FiO2 is defined as the concentration of oxygen that a person inhales. The... read more

ECMO, An Issue of Critical Care Clinics

ECMO, An Issue of Critical Care Clinics

This issue of Critical Care Clinics focuses on Mechanical Circulartory Support. Editors Nitin Puri and Michael Baram have assembled an expert team of authors on topics such as: History of Extracorporeal Membrane Oxygenation... read more

Lack of Association of High Backrest With Sacral Tissue Changes in Adults Receiving Mechanical Ventilation

Lack of Association of High Backrest With Sacral Tissue Changes in Adults Receiving Mechanical Ventilation

Although higher backrest elevation may be a theoretical risk for integrity of sacral tissues, few data support use of high backrest elevation. Level of backrest elevation is not associated with changes in tissue integrity.... read more

Noninvasive Ventilation in Patients With Do-Not-Intubate and Comfort-Measures-Only Orders

Noninvasive Ventilation in Patients With Do-Not-Intubate and Comfort-Measures-Only Orders

A large proportion of patients with do-not-intubate orders who received noninvasive ventilation survived to hospital discharge and at 1 year, with limited data showing no decrease in quality of life in survivors. Provision... read more

Finding the Best Strategy to Improve Weaning Outcomes

Finding the Best Strategy to Improve Weaning Outcomes

Respiratory muscle dysfunction, being a common cause of weaning failure, is strongly associated with prolonged mechanical ventilation (MV) and prolonged stay in intensive care units. Strategies to improve weaning outcomes... read more

The effect of neuromuscular blockade on the efficiency of facemask ventilation in patients difficult to facemask ventilate

The effect of neuromuscular blockade on the efficiency of facemask ventilation in patients difficult to facemask ventilate

Facemask ventilation of the lungs can be an important rescue intervention in a "cannot intubate" scenario. We assessed the effect of neuromuscular blockade on expiratory tidal volumes in patients with expected difficulty... read more

Noninvasive Ventilation in Hypercapnic COPD

Noninvasive Ventilation in Hypercapnic COPD

Recently, Murphy and colleagues reported findings from a clinical trial designed to evaluate the effect of home noninvasive ventilation (NIV) with oxygen on time to readmission or death in patients with persistent hypercapnia... read more

Variation of Poorly Ventilated Lung Units Measured by EIT to Dynamically Assess Recruitment

Variation of Poorly Ventilated Lung Units Measured by EIT to Dynamically Assess Recruitment

Assessing alveolar recruitment at different positive end-expiratory pressure (PEEP) levels is a major clinical and research interest because protective ventilation implies opening the lung without inducing overdistention.... read more

Early Application of APRV May Reduce the Duration of Mechanical Ventilation in ARDS

Early Application of APRV May Reduce the Duration of Mechanical Ventilation in ARDS

Compared with LTV, early application of airway pressure release ventilation (APRV) in patients with ARDS improved oxygenation and respiratory system compliance, decreased Pplat and reduced the duration of both mechanical... read more

Principles And Practice of Mechanical Ventilation

Principles And Practice of Mechanical Ventilation

A comprehensive, authoritative coverage of all the clinical, pharmacological, and technical issues surrounding the use of mechanical ventilation. More than 100 authors, all of whom are at the forefront of research in their... read more

Predictors of Intubation in Patients With AHRF Treated With a Noninvasive Oxygenation Strategy

Predictors of Intubation in Patients With AHRF Treated With a Noninvasive Oxygenation Strategy

In patients with acute hypoxemic respiratory failure breathing spontaneously, the respiratory rate was a predictor of intubation under standard oxygen, but not under high-flow nasal cannula oxygen or noninvasive ventilation.... read more