Tag: ventilation
Systemic and Microcirculatory Effects of Blood Transfusion in Experimental Hemorrhagic Shock
The microvascular reperfusion injury after retransfusion has not been completely characterized. Specifically, the question of heterogeneity among different microvascular beds needs to be addressed. In addition, the identification... read more
Hemodialysis and Survival in Intubated Salicylate-Poisoned Patients
Salicylate-poisoned patients can be incredibly complex and severely ill. Secondary to the significant acid-base abnormalities that can accompany salicylate poisoning, hemodialysis (HD) is sometimes required to facilitate... read more
Post Intubation Hypotension: The AH SHITE mnemonic
Here is a crowd sourced approach that will allow most etiologies of post intubation hypotension to be identified: The AH SHITE mnemonic is something that you can quickly run through en route to the patient’s room, or at... read more
Antipyretic Therapy in Critically Ill Septic Patients
This meta-analysis aimed to examine the impact of antipyretic therapy on mortality in critically ill septic adults. Inclusion criteria were observational or randomized studies of septic patients, evaluation of antipyretic... read more
Spontaneous Breathing during Mechanical Ventilation. Risks, Mechanisms, and Management
Spontaneous respiratory effort during mechanical ventilation has long been recognized to improve oxygenation, and because oxygenation is a key management target, such effort may seem beneficial. Also, disuse and loss of peripheral... read more
Comparison of Alveolar Recruitment Strategies for Preventing Postoperative Pulmonary Complications
This randomized clinical trial compares the effects of adding an intensive vs moderate alveolar recruitment strategy to protective ventilation on the number and severity of pulmonary complications following cardiac surgery.... read more
Use of ‘tidal volume challenge’ to improve the reliability of pulse pressure variation
Fluid loading is usually the first step in the resuscitation of patients with acute circulatory failure. Fluid responsiveness is defined as the ability of the left ventricle to increase its stroke volume in response to fluid... read more
Mechanical Ventilation: Which Patients Benefit from High PEEP?
Among patients with hypoxaemia after cardiac surgery, the use of an intensive alveolar recruitment strategy compared with a moderate recruitment strategy resulted in less severe pulmonary complications during the hospital... read more
Predicting and measuring fluid responsiveness with echocardiography
Echocardiography is an essential tool to predict and measure fluid responsiveness, according to a recent article, which provides a practical guide. Ashley Miller and Justin Mandeville outline the physiological basis of fluid... read more
Clinical review: The ABC of weaning failure
About 20% to 30% of patients are difficult to wean from invasive mechanical ventilation. The pathophysiology of difficult weaning is complex. Accordingly, determining the reason for difficult weaning and subsequently developing... read more
The ICM research agenda on ICU-acquired weakness
Intensive care unit (ICU)-acquired weakness (ICUAW) develops as a complication of critical illness and may represent the extreme end of a spectrum of weakness that begins with any serious illness regardless of care location.... read more
An Educational Intervention Optimizes the Use of Arterial Blood Gas Determinations Across ICUs
The large scale implementation of guidelines for ABG use reduced the number of inappropriately ordered ABG determinations over seven different multidisciplinary ICUs, without negatively impacting patient care. We saw a reduction... read more
Opening pressures and atelectrauma in ARDS
Data show that the prerequisites of the open lung strategy are not satisfied using PEEP up to 15 cmH2O and plateau pressure up to 30 cmH2O. For an effective open lung strategy, higher pressures are required. Therefore,... read more
National ICU Quality Indicators Revisited
The use of QI at a national level is a suitable method to focus on quality in healthcare. Independently of public access to the results, a local or national ICU network will have a lot to gain from engaging in the process... read more
Effects of Neuromuscular Blockers on Transpulmonary Pressures in Moderate to Severe ARDS
Thirty patients were included, 24 with moderate ARDS and 6 with severe ARDS. NMBA infusion was associated with an improvement in oxygenation in both moderate and severe ARDS, accompanied by a decrease in both plateau pressure... read more
Delirium: Thinking Clearly About a Foggy Issue
Benzodiazepines are one of the leading causes of delirium. These drugs are already falling out of favor in critical care settings for other reasons; they are not easily titratable, and research suggests they can prolong a... read more
A randomized placebo-controlled phase II study of a Pseudomonas vaccine in ventilated ICU patients
This phase II study has shown that IC43 vaccination of ventilated ICU patients produced a significant immunogenic effect. P. aeruginosa infection rates did not differ significantly between groups. In the absence of any difference... read more
New Infection Data and Sepsis-Guideline Critique at SCCM
The potential of probiotics to reduce nosocomial infections and ventilator-associated pneumonia in the critically ill and the latest data on readmissions will be among the major research advances presented here at the Society... read more
Liberation from Mechanical Ventilation in Critically Ill Adults
Official Executive Summary of an American Thoracic Society/American College of Chest Physicians Clinical Practice Guideline: Liberation from Mechanical Ventilation in Critically Ill Adults. The panel provides recommendations... read more
Spinraza Cuts Risk of Permanent Ventilation with SMA
Biogen announced new data from the Phase 3 ENDEAR study that showed a statistically significant reduction in the risk of death or permanent ventilation in Spinraza (nusinersen)-treated infants with spinal muscular atrophy... read more
In-Bed Cycling Feasible for ICU Patients on Ventilation
TryCYCLE was the first study in the CYCLE research program. In TryCYCLE, we determined it was safe and feasible to bike with mechanically ventilated medical surgical patients very early in their ICU stay.... read more
End-Inspiratory Pause Prolongation in ARDS Patients
Prolonging EIP allowed a significant decrease in Vt without changes in PaCO2 in passively ventilated ARDS patients. This produced a significant decrease in plateau pressure and driving pressure and significantly increased... read more
