Tag: ventilation
Delirium: Thinking Clearly About a Foggy Issue
Benzodiazepines are one of the leading causes of delirium. These drugs are already falling out of favor in critical care settings for other reasons; they are not easily titratable, and research suggests they can prolong a... read more
A randomized placebo-controlled phase II study of a Pseudomonas vaccine in ventilated ICU patients
This phase II study has shown that IC43 vaccination of ventilated ICU patients produced a significant immunogenic effect. P. aeruginosa infection rates did not differ significantly between groups. In the absence of any difference... read more
New Infection Data and Sepsis-Guideline Critique at SCCM
The potential of probiotics to reduce nosocomial infections and ventilator-associated pneumonia in the critically ill and the latest data on readmissions will be among the major research advances presented here at the Society... read more
Liberation from Mechanical Ventilation in Critically Ill Adults
Official Executive Summary of an American Thoracic Society/American College of Chest Physicians Clinical Practice Guideline: Liberation from Mechanical Ventilation in Critically Ill Adults. The panel provides recommendations... read more
Spinraza Cuts Risk of Permanent Ventilation with SMA
Biogen announced new data from the Phase 3 ENDEAR study that showed a statistically significant reduction in the risk of death or permanent ventilation in Spinraza (nusinersen)-treated infants with spinal muscular atrophy... read more
In-Bed Cycling Feasible for ICU Patients on Ventilation
TryCYCLE was the first study in the CYCLE research program. In TryCYCLE, we determined it was safe and feasible to bike with mechanically ventilated medical surgical patients very early in their ICU stay.... read more
End-Inspiratory Pause Prolongation in ARDS Patients
Prolonging EIP allowed a significant decrease in Vt without changes in PaCO2 in passively ventilated ARDS patients. This produced a significant decrease in plateau pressure and driving pressure and significantly increased... read more
Non-invasive Respiratory Support and Methylxanthines Reduce Re-Intubations
In a meta-analysis of randomized studies evaluating efforts to reduce re-intubations and respiratory failure in preterm infants, non-invasive respiratory support and use of methylxanthines (theophylline, caffeine) were found... read more
Dexmedetomidine Use in Critically-Ill Children with Acute Respiratory Failure
Margaret Parker, MD, MCCM, speaks with Mary Jo C. Grant, APRN, PhD, about the article, "Dexmedetomidine Use in Critically-Ill Children with Acute Respiratory Failure," published in the December 2016 issue of Pediatric... read more
Skeletal muscle quality as assessed by CT-derived skeletal muscle density is associated with 6-month mortality in mechanically ventilated critically ill patients
Low skeletal muscle quality at ICU admission, as assessed by CT-derived skeletal muscle density, is independently associated with higher 6-month mortality in mechanically ventilated patients. Thus, muscle quality as well... read more
Apnoeic oxygenation via high-flow nasal cannula oxygen combined with non-invasive ventilation preoxygenation for intubation in hypoxaemic patients in the intensive care unit
A novel strategy for preoxygenation in hypoxaemic patients, adding HFNC for apnoeic oxygenation to NIV prior to orotracheal intubation, may be more effective in reducing the severity of oxygen desaturation than the reference... read more
Limited predictability of maximal muscular pressure using the difference between peak airway pressure and positive end-expiratory pressure during proportional assist ventilation (PAV)
Deducing maximal muscular pressure from ΔP during PAV has limited accuracy. The extrapolated pressure time product from ΔP is usually less than the pressure time product calculated from oesophageal pressure tracing.... read more
Recruitment manoeuvres for adults with acute respiratory distress syndrome receiving mechanical ventilation
Ten trials met the inclusion criteria for this review (n = 1658 participants). We found five trials to be at low risk of bias and five to be at moderate risk of bias.... read more
Cricoid Pressure at Lower Forces Does Not Increase Oxygen Consumption
A pilot study has found that patients randomly assigned to cricoid pressure or sham treatment showed no difference in time to lowest peripheral capillary oxygen saturation (SpO2) or lowest SpO2 during anesthesia induction... read more
Spontaneous breathing trial and post-extubation work of breathing in morbidly obese critically ill patients
Predicting whether an obese critically ill patient can be successfully extubated may be specially challenging. Several weaning tests have been described but no physiological study has evaluated the weaning test that would... read more
