A randomized trial of supplemental parenteral nutrition in underweight and overweight critically ill patients

link.springer.com June 11, 2017

Nutrition guidelines recommendations differ on the use of parenteral nutrition (PN), and existingclinical trial data are inconclusive. Our recent observational data show that amounts of energy/protein receivedearly in the intensive care unit (ICU) affect patient mortality, particularly for inadequate nutrition intake in patientswith body mass indices (BMIs) of <25 or >35. Thus, we hypothesized increased nutrition delivery via supplementalPN (SPN) + enteral nutrition (EN) to underweight and obese ICU patients would improve 60-day survival and qualityof life (QoL) versus usual care (EN alone).