A volume of fluid challenge (FC) of 250 ml with a threshold of 9.6% increase in stroke volume (SV) showed the highest accuracy in detecting fluid responsiveness in critically ill patients with shock.

A prospective observational study was conducted in critically ill patients with circulatory failure.

Patients monitored with oesophageal Doppler and assigned to an FC of 500 ml of crystalloid were included.

Forty-five patients were included.

The AUC increased with cumulative volumes of FC up to 250 ml, followed by a plateau above 0.95 of AUC.

The optimal volume was 250 ml, associated with a specificity of 0.89, a sensitivity of 0.92, and a threshold of 9.6% increase in SV.

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